Hyaluronan-binding protein 2 (EC 3.4.21.-) (Factor VII-activating protease) (Factor seven-activating protease) (FSAP) (Hepatocyte growth factor activator-like protein) (Plasma hyaluronan-binding protein) [Cleaved into: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form]
1_MFARM 6_ SDLHV 11_ LLLMA 16_ LVGKT 21_ ACGFS 26_ LMSLL 31_ ESLDP 36_ DWTPD 41_ QYDYS 46_ YEDYN 51_ QEENT 56_ SSTLT 61_ HAENP 66_ DWYYT 71_ EDQAD 76_ PCQPN 81_ PCEHG 86_ GDCLV 91_ HGSTF 96_ TCSCL 101_ APFSG 106_ NKCQK 111_ VQNTC 116_ KDNPC 121_ GRGQC 126_ LITQS 131_ PPYYR 136_ CVCKH 141_ PYTGP 146_ SCSQV 151_ VPVCR 156_ PNPCQ 161_ NGATC 166_ SRHKR 171_ RSKFT 176_ CACPD 181_ QFKGK 186_ FCEIG 191_ SDDCY 196_ VGDGY 201_ SYRGK 206_ MNRTV 211_ NQHAC 216_ LYWNS 221_ HLLLQ 226_ ENYNM 231_ FMEDA 236_ ETHGI 241_ GEHNF 246_ CRNPD 251_ ADEKP 256_ WCFIK 261_ VTNDK 266_ VKWEY 271_ CDVSA 276_ CSAQD 281_ VAYPE 286_ ESPTE 291_ PSTKL 296_ PGFDS 301_ CGKTE 306_ IAERK 311_ IKRIY 316_ GGFKS 321_ TAGKH 326_ PWQAS 331_ LQSSL 336_ PLTIS 341_ MPQGH 346_ FCGGA 351_ LIHPC 356_ WVLTA 361_ AHCTD 366_ IKTRH 371_ LKVVL 376_ GDQDL 381_ KKEEF 386_ HEQSF 391_ RVEKI 396_ FKYSH 401_ YNERD 406_ EIPHN 411_ DIALL 416_ KLKPV 421_ DGHCA 426_ LESKY 431_ VKTVC 436_ LPDGS 441_ FPSGS 446_ ECHIS 451_ GWGVT 456_ ETGKG 461_ SRQLL 466_ DAKVK 471_ LIANT 476_ LCNSR 481_ QLYDH 486_ MIDDS 491_ MICAG 496_ NLQKP 501_ GQDTC 506_ QGDSG 511_ GPLTC 516_ EKDGT 521_ YYVYG 526_ IVSWG 531_ LECGK 536_ RPGVY 541_ TQVTK 546_ FLNWI 551_KATIK
1: Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly (PubMed:11217080). It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form (PubMed:10754382, PubMed:11217080). Activates coagulation factor VII (Probable). May function as a tumor suppressor negatively regulating cell proliferation and cell migration (PubMed:26222560)