Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1)
1_MANFL 6_ LPRGT 11_ SSFRR 16_ FTRES 21_ LAAIE 26_ KRMAE 31_ KQARG 36_ STTLQ 41_ ESREG 46_ LPEEE 51_ APRPQ 56_ LDLQA 61_ SKKLP 66_ DLYGN 71_ PPQEL 76_ IGEPL 81_ EDLDP 86_ FYSTQ 91_ KTFIV 96_ LNKGK 101_ TIFRF 106_ SATNA 111_ LYVLS 116_ PFHPI 121_ RRAAV 126_ KILVH 131_ SLFNM 136_ LIMCT 141_ ILTNC 146_ VFMAQ 151_ HDPPP 156_ WTKYV 161_ EYTFT 166_ AIYTF 171_ ESLVK 176_ ILARG 181_ FCLHA 186_ FTFLR 191_ DPWNW 196_ LDFSV 201_ IIMAY 206_ TTEFV 211_ DLGNV 216_ SALRT 221_ FRVLR 226_ ALKTI 231_ SVISG 236_ LKTIV 241_ GALIQ 246_ SVKKL 251_ ADVMV 256_ LTVFC 261_ LSVFA 266_ LIGLQ 271_ LFMGN 276_ LRHKC 281_ VRNFT 286_ ALNGT 291_ NGSVE 296_ ADGLV 301_ WESLD 306_ LYLSD 311_ PENYL 316_ LKNGT 321_ SDVLL 326_ CGNSS 331_ DAGTC 336_ PEGYR 341_ CLKAG 346_ ENPDH 351_ GYTSF 356_ DSFAW 361_ AFLAL 366_ FRLMT 371_ QDCWE 376_ RLYQQ 381_ TLRSA 386_ GKIYM 391_ IFFML 396_ VIFLG 401_ SFYLV 406_ NLILA 411_ VVAMA 416_ YEEQN 421_ QATIA 426_ ETEEK 431_ EKRFQ 436_ EAMEM 441_ LKKEH 446_ EALTI 451_ RGVDT 456_ VSRSS 461_ LEMSP 466_ LAPVN 471_ SHERR 476_ SKRRK 481_ RMSSG 486_ TEECG 491_ EDRLP 496_ KSDSE 501_ DGPRA 506_ MNHLS 511_ LTRGL 516_ SRTSM 521_ KPRSS 526_ RGSIF 531_ TFRRR 536_ DLGSE 541_ ADFAD 546_ DENST 551_ AGESE 556_ SHHTS 561_ LLVPW 566_ PLRRT 571_ SAQGQ 576_ PSPGT 581_ SAPGH 586_ ALHGK 591_ KNSTV 596_ DCNGV 601_ VSLLG 606_ AGDPE 611_ ATSPG 616_ SHLLR 621_ PVMLE 626_ HPPDT 631_ TTPSE 636_ EPGGP 641_ QMLTS 646_ QAPCV 651_ DGFEE 656_ PGARQ 661_ RALSA 666_ VSVLT 671_ SALEE 676_ LEESR 681_ HKCPP 686_ CWNRL 691_ AQRYL 696_ IWECC 701_ PLWMS 706_ IKQGV 711_ KLVVM 716_ DPFTD 721_ LTITM 726_ CIVLN 731_ TLFMA 736_ LEHYN 741_ MTSEF 746_ EEMLQ 751_ VGNLV 756_ FTGIF 761_ TAEMT 766_ FKIIA 771_ LDPYY 776_ YFQQG 781_ WNIFD 786_ SIIVI 791_ LSLME 796_ LGLSR 801_ MSNLS 806_ VLRSF 811_ RLLRV 816_ FKLAK 821_ SWPTL 826_ NTLIK 831_ IIGNS 836_ VGALG 841_ NLTLV 846_ LAIIV 851_ FIFAV 856_ VGMQL 861_ FGKNY 866_ SELRD 871_ SDSGL 876_ LPRWH 881_ MMDFF 886_ HAFLI 891_ IFRIL 896_ CGEWI 901_ ETMWD 906_ CMEVS 911_ GQSLC 916_ LLVFL 921_ LVMVI 926_ GNLVV 931_ LNLFL 936_ ALLLS 941_ SFSAD 946_ NLTAP 951_ DEDRE 956_ MNNLQ 961_ LALAR 966_ IQRGL 971_ RFVKR 976_ TTWDF 981_ CCGLL 986_ RQRPQ 991_ KPAAL 996_ AAQGQ 1001_ LPSCI 1006_ ATPYS 1011_ PPPPE 1016_ TEKVP 1021_ PTRKE 1026_ TRFEE 1031_ GEQPG 1036_ QGTPG 1041_ DPEPV 1046_ CVPIA 1051_ VAESD 1056_ TDDQE 1061_ EDEEN 1066_ SLGTE 1071_ EESSK 1076_ QQESQ 1081_ PVSGG 1086_ PEAPP 1091_ DSRTW 1096_ SQVSA 1101_ TASSE 1106_ AEASA 1111_ SQADW 1116_ RQQWK 1121_ AEPQA 1126_ PGCGE 1131_ TPEDS 1136_ CSEGS 1141_ TADMT 1146_ NTAEL 1151_ LEQIP 1156_ DLGQD 1161_ VKDPE 1166_ DCFTE 1171_ GCVRR 1176_ CPCCA 1181_ VDTTQ 1186_ APGKV 1191_ WWRLR 1196_ KTCYH 1201_ IVEHS 1206_ WFETF 1211_ IIFMI 1216_ LLSSG 1221_ ALAFE 1226_ DIYLE 1231_ ERKTI 1236_ KVLLE 1241_ YADKM 1246_ FTYVF 1251_ VLEML 1256_ LKWVA 1261_ YGFKK 1266_ YFTNA 1271_ WCWLD 1276_ FLIVD 1281_ VSLVS 1286_ LVANT 1291_ LGFAE 1296_ MGPIK 1301_ SLRTL 1306_ RALRP 1311_ LRALS 1316_ RFEGM 1321_ RVVVN 1326_ ALVGA 1331_ IPSIM 1336_ NVLLV 1341_ CLIFW 1346_ LIFSI 1351_ MGVNL 1356_ FAGKF 1361_ GRCIN 1366_ QTEGD 1371_ LPLNY 1376_ TIVNN 1381_ KSQCE 1386_ SLNLT 1391_ GELYW 1396_ TKVKV 1401_ NFDNV 1406_ GAGYL 1411_ ALLQV 1416_ ATFKG 1421_ WMDIM 1426_ YAAVD 1431_ SRGYE 1436_ EQPQW 1441_ EYNLY 1446_ MYIYF 1451_ VIFII 1456_ FGSFF 1461_ TLNLF 1466_ IGVII 1471_ DNFNQ 1476_ QKKKL 1481_ GGQDI 1486_ FMTEE 1491_ QKKYY 1496_ NAMKK 1501_ LGSKK 1506_ PQKPI 1511_ PRPLN 1516_ KYQGF 1521_ IFDIV 1526_ TKQAF 1531_ DVTIM 1536_ FLICL 1541_ NMVTM 1546_ MVETD 1551_ DQSPE 1556_ KINIL 1561_ AKINL 1566_ LFVAI 1571_ FTGEC 1576_ IVKLA 1581_ ALRHY 1586_ YFTNS 1591_ WNIFD 1596_ FVVVI 1601_ LSIVG 1606_ TVLSD 1611_ IIQKY 1616_ FFSPT 1621_ LFRVI 1626_ RLARI 1631_ GRILR 1636_ LIRGA 1641_ KGIRT 1646_ LLFAL 1651_ MMSLP 1656_ ALFNI 1661_ GLLLF 1666_ LVMFI 1671_ YSIFG 1676_ MANFA 1681_ YVKWE 1686_ AGIDD 1691_ MFNFQ 1696_ TFANS 1701_ MLCLF 1706_ QITTS 1711_ AGWDG 1716_ LLSPI 1721_ LNTGP 1726_ PYCDP 1731_ TLPNS 1736_ NGSRG 1741_ DCGSP 1746_ AVGIL 1751_ FFTTY 1756_ IIISF 1761_ LIVVN 1766_ MYIAI 1771_ ILENF 1776_ SVATE 1781_ ESTEP 1786_ LSEDD 1791_ FDMFY 1796_ EIWEK 1801_ FDPEA 1806_ TQFIE 1811_ YSVLS 1816_ DFADA 1821_ LSEPL 1826_ RIAKP 1831_ NQISL 1836_ INMDL 1841_ PMVSG 1846_ DRIHC 1851_ MDILF 1856_ AFTKR 1861_ VLGES 1866_ GEMDA 1871_ LKIQM 1876_ EEKFM 1881_ AANPS 1886_ KISYE 1891_ PITTT 1896_ LRRKH 1901_ EEVSA 1906_ MVIQR 1911_ AFRRH 1916_ LLQRS 1921_ LKHAS 1926_ FLFRQ 1931_ QAGSG 1936_ LSEED 1941_ APERE 1946_ GLIAY 1951_ VMSEN 1956_ FSRPL 1961_ GPPSS 1966_ SSISS 1971_ TSFPP 1976_ SYDSV 1981_ TRATS 1986_ DNLQV 1991_ RGSDY 1996_ SHSED 2001_ LADFP 2006_ PSPDR 2011_DRESI
1: Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity)