Hypermethylated in cancer 1 protein (Hic-1) (Zinc finger and BTB domain-containing protein 29)
1_MTFPE 6_ ADILL 11_ KSGEC 16_ AGQTM 21_ LDTME 26_ APGHS 31_ RQLLL 36_ QLNNQ 41_ RTKGF 46_ LCDVI 51_ IVVQN 56_ ALFRA 61_ HKNVL 66_ AASSA 71_ YLKSL 76_ VVHDN 81_ LLNLD 86_ HDMVS 91_ PAVFR 96_ LVLDF 101_ IYTGR 106_ LADGA 111_ EAAAA 116_ AAVAP 121_ GAEPS 126_ LGAVL 131_ AAASY 136_ LQIPD 141_ LVALC 146_ KKRLK 151_ RHGKY 156_ CHLRG 161_ GGGGG 166_ GGYAP 171_ YGRPG 176_ RGLRA 181_ ATPVI 186_ QACYP 191_ SPVGP 196_ PPPPA 201_ AEPPS 206_ GPEAA 211_ VNTHC 216_ AELYA 221_ SGPGP 226_ AAALC 231_ ASERR 236_ CSPLC 241_ GLDLS 246_ KKSPP 251_ GSAAP 256_ ERPLA 261_ ERELP 266_ PRPDS 271_ PPSAG 276_ PAAYK 281_ EPPLA 286_ LPSLP 291_ PLPFQ 296_ KLEEA 301_ APPSD 306_ PFRGG 311_ SGSPG 316_ PEPPG 321_ RPDGP 326_ SLLYR 331_ WMKHE 336_ PGLGS 341_ YGDEL 346_ GRERG 351_ SPSER 356_ CEERG 361_ GDAAV 366_ SPGGP 371_ PLGLA 376_ PPPRY 381_ PGSLD 386_ GPGAG 391_ GDGDD 396_ YKSSS 401_ EETGS 406_ SEDPS 411_ PPGGH 416_ LEGYP 421_ CPHLA 426_ YGEPE 431_ SFGDN 436_ LYVCI 441_ PCGKG 446_ FPSSE 451_ QLNAH 456_ VEAHV 461_ EEEEA 466_ LYGRA 471_ EAAEV 476_ AAGAA 481_ GLGPP 486_ FGGGG 491_ DKVAG 496_ APGGL 501_ GELLR 506_ PYRCA 511_ SCDKS 516_ YKDPA 521_ TLRQH 526_ EKTHW 531_ LTRPY 536_ PCTIC 541_ GKKFT 546_ QRGTM 551_ TRHMR 556_ SHLGL 561_ KPFAC 566_ DACGM 571_ RFTRQ 576_ YRLTE 581_ HMRIH 586_ SGEKP 591_ YECQV 596_ CGGKF 601_ AQQRN 606_ LISHM 611_ KMHAV 616_ GGAAG 621_ AAGAL 626_ AGLGG 631_ LPGVP 636_ GPDGK 641_ GKLDF 646_ PEGVF 651_ AVARL 656_ TAEQL 661_ SLKQQ 666_ DKAAA 671_ AELLA 676_ QTTHF 681_ LHDPK 686_ VALES 691_ LYPLA 696_ KFTAE 701_ LGLSP 706_ DKAAE 711_ VLSQG 716_ AHLAA 721_ GPDGR 726_TIDRF
1: Transcriptional repressor (PubMed:12052894, PubMed:15231840). Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' (PubMed:15231840). May act as a tumor suppressor (PubMed:20154726). Involved in development of head, face, limbs and ventral body wall (By similarity). Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses (PubMed:16269335). The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1 (PubMed:12052894, PubMed:20547755). In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells (PubMed:20547755). Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes (PubMed:16724116). Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex (PubMed:18347096, PubMed:19486893). Probably represses transcription of ACKR3, FGFBP1 and EFNA1 (PubMed:16690027, PubMed:19525223, PubMed:20154726)