Helicase-like transcription factor (EC 2.3.2.27) (EC 3.6.4.-) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (HIP116) (RING finger protein 80) (RING-type E3 ubiquitin transferase HLTF) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3)
1_MSWMF 6_ KRDPV 11_ WKYLQ 16_ TVQYG 21_ VHGNF 26_ PRLSY 31_ PTFFP 36_ RFEFQ 41_ DVIPP 46_ DDFLT 51_ SDEEV 56_ DSVLF 61_ GSLRG 66_ HVVGL 71_ RYYTG 76_ VVNNN 81_ EMVAL 86_ QRDPN 91_ NPYDK 96_ NAIKV 101_ NNVNG 106_ NQVGH 111_ LKKEL 116_ AGALA 121_ YIMDN 126_ KLAQI 131_ EGVVP 136_ FGANN 141_ AFTMP 146_ LHMTF 151_ WGKEE 156_ NRKAV 161_ SDQLK 166_ KHGFK 171_ LGPAP 176_ KTLGF 181_ NLESG 186_ WGSGR 191_ AGPSY 196_ SMPVH 201_ AAVQM 206_ TTEQL 211_ KTEFD 216_ KLFED 221_ LKEDD 226_ KTHEM 231_ EPAEA 236_ IETPL 241_ LPHQK 246_ QALAW 251_ MVSRE 256_ NSKEL 261_ PPFWE 266_ QRNDL 271_ YYNTI 276_ TNFSE 281_ KDRPE 286_ NVHGG 291_ ILADD 296_ MGLGK 301_ TLTAI 306_ AVILT 311_ NFHDG 316_ RPLPI 321_ ERVKK 326_ NLLKK 331_ EYNVN 336_ DDSMK 341_ LGGNN 346_ TSEKA 351_ DGLSK 356_ DASRC 361_ SEQPS 366_ ISDIK 371_ EKSKF 376_ RMSEL 381_ SSSRP 386_ KRRKT 391_ AVQYI 396_ ESSDS 401_ EEIET 406_ SELPQ 411_ KMKGK 416_ LKNVQ 421_ SETKG 426_ RAKAG 431_ SSKVI 436_ EDVAF 441_ ACALT 446_ SSVPT 451_ TKKKM 456_ LKKGA 461_ CAVEG 466_ SKKTD 471_ VEERP 476_ RTTLI 481_ ICPLS 486_ VLSNW 491_ IDQFG 496_ QHIKS 501_ DVHLN 506_ FYVYY 511_ GPDRI 516_ REPAL 521_ LSKQD 526_ IVLTT 531_ YNILT 536_ HDYGT 541_ KGDSP 546_ LHSIR 551_ WLRVI 556_ LDEGH 561_ AIRNP 566_ NAQQT 571_ KAVLD 576_ LESER 581_ RWVLT 586_ GTPIQ 591_ NSLKD 596_ LWSLL 601_ SFLKL 606_ KPFID 611_ REWWH 616_ RTIQR 621_ PVTMG 626_ DEGGL 631_ RRLQS 636_ LIKNI 641_ TLRRT 646_ KTSKI 651_ KGKPV 656_ LELPE 661_ RKVFI 666_ QHITL 671_ SDEER 676_ KIYQS 681_ VKNEG 686_ RATIG 691_ RYFNE 696_ GTVLA 701_ HYADV 706_ LGLLL 711_ RLRQI 716_ CCHTY 721_ LLTNA 726_ VSSNG 731_ PSGND 736_ TPEEL 741_ RKKLI 746_ RKMKL 751_ ILSSG 756_ SDEEC 761_ AICLD 766_ SLTVP 771_ VITHC 776_ AHVFC 781_ KPCIC 786_ QVIQN 791_ EQPHA 796_ KCPLC 801_ RNDIH 806_ EDNLL 811_ ECPPE 816_ ELARD 821_ SEKKS 826_ DMEWT 831_ SSSKI 836_ NALMH 841_ ALTDL 846_ RKKNP 851_ NIKSL 856_ VVSQF 861_ TTFLS 866_ LIEIP 871_ LKASG 876_ FVFTR 881_ LDGSM 886_ AQKKR 891_ VESIQ 896_ CFQNT 901_ EAGSP 906_ TIMLL 911_ SLKAG 916_ GVGLN 921_ LSAAS 926_ RVFLM 931_ DPAWN 936_ PAAED 941_ QCFDR 946_ CHRLG 951_ QKQEV 956_ IITKF 961_ IVKDS 966_ VEENM 971_ LKIQN 976_ KKREL 981_ AAGAF 986_ GTKKP 991_ NADEM 996_ KQAKI 1001_NEIRT
1: Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA