Equilibrative nucleoside transporter 2 (36 kDa nucleolar protein HNP36) (Delayed-early response protein 12) (Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter) (Equilibrative NBMPR-insensitive nucleoside transporter) (Hydrophobic nucleolar protein, 36 kDa) (Nucleoside transporter, ei-type) (Solute carrier family 29 member 2)
1_MARGD 6_ APRDS 11_ YHLVG 16_ ISFFI 21_ LGLGT 26_ LLPWN 31_ FFITA 36_ IPYFQ 41_ ARLAG 46_ AGNST 51_ ARILS 56_ TNHTG 61_ PEDAF 66_ NFNNW 71_ VTLLS 76_ QLPLL 81_ LFTLL 86_ NSFLY 91_ QCVPE 96_ TVRIL 101_ GSLLA 106_ ILLLF 111_ ALTAA 116_ LVKVD 121_ MSPGP 126_ FFSIT 131_ MASVC 136_ FINSF 141_ SAVLQ 146_ GSLFG 151_ QLGTM 156_ PSTYS 161_ TLFLS 166_ GQGLA 171_ GIFAA 176_ LAMLL 181_ SMASG 186_ VDAET 191_ SALGY 196_ FITPC 201_ VGILM 206_ SIVCY 211_ LSLPH 216_ LKFAR 221_ YYLAN 226_ KSSQA 231_ QAQEL 236_ ETKAE 241_ LLQSD 246_ ENGIP 251_ SSPQK 256_ VALTL 261_ DLDLE 266_ KEPES 271_ EPDEP 276_ QKPGK 281_ PSVFT 286_ VFQKI 291_ WLTAL 296_ CLVLV 301_ FTVTL 306_ SVFPA 311_ ITAMV 316_ TSSTS 321_ PGKWS 326_ QFFNP 331_ ICCFL 336_ LFNIM 341_ DWLGR 346_ SLTSY 351_ FLWPD 356_ EDSRL 361_ LPLLV 366_ CLRFL 371_ FVPLF 376_ MLCHV 381_ PQRSR 386_ LPILF 391_ PQDAY 396_ FITFM 401_ LLFAV 406_ SNGYL 411_ VSLTM 416_ CLAPR 421_ QVLPH 426_ EREVA 431_ GALMT 436_ FFLAL 441_ GLSCG 446_ ASLSF 451_LFKAL
1: Bidirectional uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis (PubMed:10722669, PubMed:12527552, PubMed:12590919, PubMed:16214850, PubMed:21795683, PubMed:9396714, PubMed:9478986). Functions as a Na(+)-independent, passive transporter (PubMed:9478986). Involved in the transport of nucleosides such as inosine, adenosine, uridine, thymidine, cytidine and guanosine (PubMed:10722669, PubMed:12527552, PubMed:12590919, PubMed:16214850, PubMed:21795683, PubMed:9396714, PubMed:9478986). Also able to transport purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) (PubMed:16214850, PubMed:21795683). Involved in nucleoside transport at basolateral membrane of kidney cells, allowing liver absorption of nucleoside metabolites (PubMed:12527552). Mediates apical nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis-barrier (PubMed:23639800). Mediates both the influx and efflux of hypoxanthine in skeletal muscle microvascular endothelial cells to control the amount of intracellular hypoxanthine available for xanthine oxidase-mediated ROS production (By similarity)
2: Non functional nucleoside transporter protein for adenosine or thymidine transport. Does not express on cell membrane