DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM)
1_MDLAA 6_ AAEPG 11_ AGSQH 16_ LEVRD 21_ EVAEK 26_ CQKLF 31_ LDFLE 36_ EFQSS 41_ DGEIK 46_ YLQLA 51_ EELIR 56_ PERNT 61_ LVVSF 66_ VDLEQ 71_ FNQQL 76_ STTIQ 81_ EEFYR 86_ VYPYL 91_ CRALK 96_ TFVKD 101_ RKEIP 106_ LAKDF 111_ YVAFQ 116_ DLPTR 121_ HKIRE 126_ LTSSR 131_ IGLLT 136_ RISGQ 141_ VVRTH 146_ PVHPE 151_ LVSGT 156_ FLCLD 161_ CQTVI 166_ RDVEQ 171_ QFKYT 176_ QPNIC 181_ RNPVC 186_ ANRRR 191_ FLLDT 196_ NKSRF 201_ VDFQK 206_ VRIQE 211_ TQAEL 216_ PRGSI 221_ PRSLE 226_ VILRA 231_ EAVES 236_ AQAGD 241_ KCDFT 246_ GTLIV 251_ VPDVS 256_ KLSTP 261_ GARAE 266_ TNSRV 271_ SGVDG 276_ YETEG 281_ IRGLR 286_ ALGVR 291_ DLSYR 296_ LVFLA 301_ CCVAP 306_ TNPRF 311_ GGKEL 316_ RDEEQ 321_ TAESI 326_ KNQMT 331_ VKEWE 336_ KVFEM 341_ SQDKN 346_ LYHNL 351_ CTSLF 356_ PTIHG 361_ NDEVK 366_ RGVLL 371_ MLFGG 376_ VPKTT 381_ GEGTS 386_ LRGDI 391_ NVCIV 396_ GDPST 401_ AKSQF 406_ LKHVE 411_ EFSPR 416_ AVYTS 421_ GKASS 426_ AAGLT 431_ AAVVR 436_ DEESH 441_ EFVIE 446_ AGALM 451_ LADNG 456_ VCCID 461_ EFDKM 466_ DVRDQ 471_ VAIHE 476_ AMEQQ 481_ TISIT 486_ KAGVK 491_ ATLNA 496_ RTSIL 501_ AAANP 506_ ISGHY 511_ DRSKS 516_ LKQNI 521_ NLSAP 526_ IMSRF 531_ DLFFI 536_ LVDEC 541_ NEVTD 546_ YAIAR 551_ RIVDL 556_ HSRIE 561_ ESIDR 566_ VYSLD 571_ DIRRY 576_ LLFAR 581_ QFKPK 586_ ISKES 591_ EDFIV 596_ EQYKH 601_ LRQRD 606_ GSGVT 611_ KSSWR 616_ ITVRQ 621_ LESMI 626_ RLSEA 631_ MARMH 636_ CCDEV 641_ QPKHV 646_ KEAFR 651_ LLNKS 656_ IIRVE 661_ TPDVN 666_ LDQEE 671_ EIQME 676_ VDEGA 681_ GGING 686_ HADSP 691_ APVNG 696_ INGYN 701_ EDINQ 706_ ESAPK 711_ ASLRL 716_ GFSEY 721_ CRISN 726_ LIVLH 731_ LRKVE 736_ EEEDE 741_ SALKR 746_ SELVN 751_ WYLKE 756_ IESEI 761_ DSEEE 766_ LINKK 771_ RIIEK 776_ VIHRL 781_ THYDH 786_ VLIEL 791_ TQAGL 796_ KGSTE 801_ GSESY 806_ EEDPY 811_ LVVNP 816_NYLLE
1: Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425)