Inositol 1,4,5-trisphosphate receptor type 3 (IP3 receptor isoform 3) (IP3R 3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor)
1_MSEMS 6_ SFLHI 11_ GDIVS 16_ LYAEG 21_ SVNGF 26_ ISTLG 31_ LVDDR 36_ CVVEP 41_ AAGDL 46_ DNPPK 51_ KFRDC 56_ LFKVC 61_ PMNRY 66_ SAQKQ 71_ YWKAK 76_ QTKQD 81_ KEKIA 86_ DVVLL 91_ QKLQH 96_ AAQME 101_ QKQND 106_ TENKK 111_ VHGDV 116_ VKYGS 121_ VIQLL 126_ HMKSN 131_ KYLTV 136_ NKRLP 141_ ALLEK 146_ NAMRV 151_ TLDAT 156_ GNEGS 161_ WLFIQ 166_ PFWKL 171_ RSNGD 176_ NVVVG 181_ DKVIL 186_ NPVNA 191_ GQPLH 196_ ASNYE 201_ LSDNA 206_ GCKEV 211_ NSVNC 216_ NTSWK 221_ INLFM 226_ QFRDH 231_ LEEVL 236_ KGGDV 241_ VRLFH 246_ AEQEK 251_ FLTCD 256_ EYKGK 261_ LQVFL 266_ RTTLR 271_ QSATS 276_ ATSSN 281_ ALWEV 286_ EVVHH 291_ DPCRG 296_ GAGHW 301_ NGLYR 306_ FKHLA 311_ TGNYL 316_ AAEEN 321_ PSYKG 326_ DASDP 331_ KAAGM 336_ GAQGR 341_ TGRRN 346_ AGEKI 351_ KYCLV 356_ AVPHG 361_ NDIAS 366_ LFELD 371_ PTTLQ 376_ KTDSF 381_ VPRNS 386_ YVRLR 391_ HLCTN 396_ TWIQS 401_ TNVPI 406_ DIEEE 411_ RPIRL 416_ MLGTC 421_ PTKED 426_ KEAFA 431_ IVSVP 436_ VSEIR 441_ DLDFA 446_ NDASS 451_ MLASA 456_ VEKLN 461_ EGFIS 466_ QNDRR 471_ FVIQL 476_ LEDLV 481_ FFVSD 486_ VPNNG 491_ QNVLD 496_ IMVTK 501_ PNRER 506_ QKLMR 511_ EQNIL 516_ KQVFG 521_ ILKAP 526_ FREKG 531_ GEGPL 536_ VRLEE 541_ LSDQK 546_ NAPYQ 551_ HMFRL 556_ CYRVL 561_ RHSQE 566_ DYRKN 571_ QEHIA 576_ KQFGM 581_ MQSQI 586_ GYDIL 591_ AEDTI 596_ TALLH 601_ NNRKL 606_ LEKHI 611_ TKTEV 616_ ETFVS 621_ LVRKN 626_ REPRF 631_ LDYLS 636_ DLCVS 641_ NHIAI 646_ PVTQE 651_ LICKC 656_ VLDPK 661_ NSDIL 666_ IRTEL 671_ RPVKE 676_ MAQSH 681_ EYLSI 686_ EYSEE 691_ EVWLT 696_ WTDKN 701_ NEHHE 706_ KSVRQ 711_ LAQEA 716_ RAGNA 721_ HDENV 726_ LSYYR 731_ YQLKL 736_ FARMC 741_ LDRQY 746_ LAIDE 751_ ISQQL 756_ GVDLI 761_ FLCMA 766_ DEMLP 771_ FDLRA 776_ SFCHL 781_ MLHVH 786_ VDRDP 791_ QELVT 796_ PVKFA 801_ RLWTE 806_ IPTAI 811_ TIKDY 816_ DSNLN 821_ ASRDD 826_ KKNKF 831_ ANTME 836_ FVEDY 841_ LNNVV 846_ SEAVP 851_ FANEE 856_ KNKLT 861_ FEVVS 866_ LAHNL 871_ IYFGF 876_ YSFSE 881_ LLRLT 886_ RTLLG 891_ IIDCV 896_ QGPPA 901_ MLQAY 906_ EDPGG 911_ KNVRR 916_ SIQGV 921_ GHMMS 926_ TMVLS 931_ RKQSV 936_ FSAPS 941_ LSAGA 946_ SAAEP 951_ LDRSK 956_ FEENE 961_ DIVVM 966_ ETKLK 971_ ILEIL 976_ QFILN 981_ VRLDY 986_ RISYL 991_ LSVFK 996_ KEFVE 1001_ VFPMQ 1006_ DSGAD 1011_ GTAPA 1016_ FDSTT 1021_ ANMNL 1026_ DRIGE 1031_ QAEAM 1036_ FGVGK 1041_ TSSML 1046_ EVDDE 1051_ GGRMF 1056_ LRVLI 1061_ HLTMH 1066_ DYAPL 1071_ VSGAL 1076_ QLLFK 1081_ HFSQR 1086_ QEAMH 1091_ TFKQV 1096_ QLLIS 1101_ AQDVE 1106_ NYKVI 1111_ KSELD 1116_ RLRTM 1121_ VEKSE 1126_ LWVDK 1131_ KGSGK 1136_ GEEVE 1141_ AGAAK 1146_ DKKER 1151_ PTDEE 1156_ GFLHP 1161_ PGEKS 1166_ SENYQ 1171_ IVKGI 1176_ LERLN 1181_ KMCGV 1186_ GEQMR 1191_ KKQQR 1196_ LLKNM 1201_ DAHKV 1206_ MLDLL 1211_ QIPYD 1216_ KGDAK 1221_ MMEIL 1226_ RYTHQ 1231_ FLQKF 1236_ CAGNP 1241_ GNQAL 1246_ LHKHL 1251_ HLFLT 1256_ PGLLE 1261_ AETMQ 1266_ HIFLN 1271_ NYQLC 1276_ SEISE 1281_ PVLQH 1286_ FVHLL 1291_ ATHGR 1296_ HVQYL 1301_ DFLHT 1306_ VIKAE 1311_ GKYVK 1316_ KCQDM 1321_ IMTEL 1326_ TNAGD 1331_ DVVVF 1336_ YNDKA 1341_ SLAHL 1346_ LDMMK 1351_ AARDG 1356_ VEDHS 1361_ PLMYH 1366_ ISLVD 1371_ LLAAC 1376_ AEGKN 1381_ VYTEI 1386_ KCTSL 1391_ LPLED 1396_ VVSVV 1401_ THEDC 1406_ ITEVK 1411_ MAYVN 1416_ FVNHC 1421_ YVDTE 1426_ VEMKE 1431_ IYTSN 1436_ HIWTL 1441_ FENFT 1446_ LDMAR 1451_ VCSKR 1456_ EKRVA 1461_ DPTLE 1466_ KYVLS 1471_ VVLDT 1476_ INAFF 1481_ SSPFS 1486_ ENSTS 1491_ LQTHQ 1496_ TIVVQ 1501_ LLQST 1506_ TRLLE 1511_ CPWLQ 1516_ QQHKG 1521_ SVEAC 1526_ IRTLA 1531_ MVAKG 1536_ RAILL 1541_ PMDLD 1546_ AHISS 1551_ MLSSG 1556_ ASCAA 1561_ AAQRN 1566_ ASSYK 1571_ ATTRA 1576_ FPRVT 1581_ PTANQ 1586_ WDYKN 1591_ IIEKL 1596_ QDIIT 1601_ ALEER 1606_ LKPLV 1611_ QAELS 1616_ VLVDV 1621_ LHWPE 1626_ LLFLE 1631_ GSEAY 1636_ QRCES 1641_ GGFLS 1646_ KLIQH 1651_ TKDLM 1656_ ESEEK 1661_ LCIKV 1666_ LRTLQ 1671_ QMLLK 1676_ KTKYG 1681_ DRGNQ 1686_ LRKML 1691_ LQNYL 1696_ QNRKS 1701_ TSRGD 1706_ LPDPI 1711_ GTGLD 1716_ PDWSA 1721_ IAATQ 1726_ CRLDK 1731_ EGATK 1736_ LVCDL 1741_ ITSTK 1746_ NEKIF 1751_ QESIG 1756_ LAIHL 1761_ LDGGN 1766_ TEIQK 1771_ SFHNL 1776_ MMSDK 1781_ KSERF 1786_ FKVLH 1791_ DRMKR 1796_ AQQET 1801_ KSTVA 1806_ VNMND 1811_ LGSQP 1816_ HEDRE 1821_ PVDPT 1826_ TKGRV 1831_ ASFSI 1836_ PGSSS 1841_ RYSLG 1846_ PSLRR 1851_ GHEVS 1856_ ERVQS 1861_ SEMGT 1866_ SVLIM 1871_ QPILR 1876_ FLQLL 1881_ CENHN 1886_ RDLQN 1891_ FLRCQ 1896_ NNKTN 1901_ YNLVC 1906_ ETLQF 1911_ LDIMC 1916_ GSTTG 1921_ GLGLL 1926_ GLYIN 1931_ EDNVG 1936_ LVIQT 1941_ LETLT 1946_ EYCQG 1951_ PCHEN 1956_ QTCIV 1961_ THESN 1966_ GIDII 1971_ TALIL 1976_ NDISP 1981_ LCKYR 1986_ MDLVL 1991_ QLKDN 1996_ ASKLL 2001_ LALME 2006_ SRHDS 2011_ ENAER 2016_ ILISL 2021_ RPQEL 2026_ VDVIK 2031_ KAYLQ 2036_ EEERE 2041_ NSEVS 2046_ PREVG 2051_ HNIYI 2056_ LALQL 2061_ SRHNK 2066_ QLQHL 2071_ LKPVK 2076_ RIQEE 2081_ EAEGI 2086_ SSMLS 2091_ LNNKQ 2096_ LSQML 2101_ KSSAP 2106_ AQEEE 2111_ EDPLA 2116_ YYENH 2121_ TSQIE 2126_ IVRQD 2131_ RSMEQ 2136_ IVFPV 2141_ PGICQ 2146_ FLTEE 2151_ TKHRL 2156_ FTTTE 2161_ QDEQG 2166_ SKVSD 2171_ FFDQS 2176_ SFLHN 2181_ EMEWQ 2186_ RKLRS 2191_ MPLIY 2196_ WFSRR 2201_ MTLWG 2206_ SISFN 2211_ LAVFI 2216_ NIIIA 2221_ FFYPY 2226_ MEGAS 2231_ TGVLD 2236_ SPLIS 2241_ LLFWI 2246_ LICFS 2251_ IAALF 2256_ TKRYS 2261_ IRPLI 2266_ VALIL 2271_ RSIYY 2276_ LGIGP 2281_ TLNIL 2286_ GALNL 2291_ TNKIV 2296_ FVVSF 2301_ VGNRG 2306_ TFIRG 2311_ YKAMV 2316_ MDMEF 2321_ LYHVG 2326_ YILTS 2331_ VLGLF 2336_ AHELF 2341_ YSILL 2346_ FDLIY 2351_ REETL 2356_ FNVIK 2361_ SVTRN 2366_ GRSIL 2371_ LTALL 2376_ ALILV 2381_ YLFSI 2386_ VGFLF 2391_ LKDDF 2396_ ILEVD 2401_ RLPNN 2406_ HSTAS 2411_ PLGMP 2416_ HGAAA 2421_ FVDTC 2426_ SGDKM 2431_ DCVSG 2436_ LSVPE 2441_ VLEED 2446_ RELDS 2451_ TERAC 2456_ DTLLM 2461_ CIVTV 2466_ MNHGL 2471_ RNGGG 2476_ VGDIL 2481_ RKPSK 2486_ DESLF 2491_ PARVV 2496_ YDLLF 2501_ FFIVI 2506_ IIVLN 2511_ LIFGV 2516_ IIDTF 2521_ ADLRS 2526_ EKQKK 2531_ EEILK 2536_ TTCFI 2541_ CGLER 2546_ DKFDN 2551_ KTVSF 2556_ EEHIK 2561_ LEHNM 2566_ WNYLY 2571_ FIVLV 2576_ RVKNK 2581_ TDYTG 2586_ PESYV 2591_ AQMIK 2596_ NKNLD 2601_ WFPRM 2606_ RAMSL 2611_ VSNEG 2616_ EGEQN 2621_ EIRIL 2626_ QDKLN 2631_ STMKL 2636_ VSHLT 2641_ AQLNE 2646_ LKEQM 2651_ TEQRK 2656_ RRQRL 2661_ GFVDV 2666_QNCIS
1: Inositol 1,4,5-trisphosphate-gated calcium channel that, upon 1D-myo-inositol 1,4,5-trisphosphate binding, transports calcium from the endoplasmic reticulum lumen to cytoplasm, thus releasing the intracellular calcium and therefore participates in cellular calcium ion homeostasis (PubMed:32949214, PubMed:37898605, PubMed:8081734, PubMed:8288584). 1D-myo-inositol 1,4,5-trisphosphate binds to the ligand-free channel without altering its global conformation, yielding the low-energy resting state, then progresses through resting-to preactivated transitions to the higher energy preactivated state, which increases affinity for calcium, promoting binding of the low basal cytosolic calcium at the juxtamembrane domain (JD) site, favoring the transition through the ensemble of high-energy intermediate states along the trajectory to the fully-open activated state (PubMed:30013099, PubMed:35301323, PubMed:37898605). Upon opening, releases calcium in the cytosol where it can bind to the low-affinity cytoplasmic domain (CD) site and stabilizes the inhibited state to terminate calcium release (PubMed:30013099, PubMed:35301323, PubMed:37898605)