Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B)
1_MEPQV 6_ TLNVT 11_ FKNEI 16_ QSFLV 21_ SDPEN 26_ TTWAD 31_ IEAMV 36_ KVSFD 41_ LNTIQ 46_ IKYLD 51_ EENEE 56_ VSINS 61_ QGEYE 66_ EALKM 71_ AVKQG 76_ NQLQM 81_ QVHEG 86_ HHVVD 91_ EAPPP 96_ VVGAK 101_ RLAAR 106_ AGKKP 111_ LAHYS 116_ SLVRV 121_ LGSDM 126_ KTPED 131_ PAVQS 136_ FPLVP 141_ CDTDQ 146_ PQDKP 151_ PDWFT 156_ SYLET 161_ FREQV 166_ VNETV 171_ EKLEQ 176_ KLHEK 181_ LVLQN 186_ PSLGS 191_ CPSEV 196_ SMPTS 201_ EETLF 206_ LPENQ 211_ FSWHI 216_ ACNNC 221_ QRRIV 226_ GVRYQ 231_ CSLCP 236_ SYNIC 241_ EDCEA 246_ GPYGH 251_ DTNHV 256_ LLKLR 261_ RPVVG 266_ SSEPF 271_ CHSKY 276_ STPRL 281_ PAALE 286_ QVRLQ 291_ KQVDK 296_ NFLKA 301_ EKQRL 306_ RAEKK 311_ QRKAE 316_ VKELK 321_ KQLKL 326_ HRKIH 331_ LWNSI 336_ HGLQS 341_ PKSPL 346_ GRPES 351_ LLQSN 356_ TLMLP 361_ LQPCT 366_ SVMPM 371_ LSAAF 376_ VDENL 381_ PDGTH 386_ LQPGT 391_ KFIKH 396_ WRMKN 401_ TGNVK 406_ WSADT 411_ KLKFM 416_ WGNLT 421_ LASTE 426_ KKDVL 431_ VPCLK 436_ AGHVG 441_ VVSVE 446_ FIAPA 451_ LEGTY 456_ TSHWR 461_ LSHKG 466_ QQFGP 471_ RVWCS 476_ IIVDP 481_ FPSEE 486_ SPDNI 491_ EKGMI 496_ SSSKT 501_ DDLTC 506_ QQEET 511_ FLLAK 516_ EERQL 521_ GEVTE 526_ QTEGT 531_ AACIP 536_ QKAKN 541_ VASER 546_ ELYIP 551_ SVDLL 556_ TAQDL 561_ LSFEL 566_ LDINI 571_ VQELE 576_ RVPHN 581_ TPVDV 586_ TPCMS 591_ PLPHD 596_ SPLIE 601_ KPGLG 606_ QIEEE 611_ NEGAG 616_ FKALP 621_ DSMVS 626_ VKRKA 631_ ENIAS 636_ VEEAE 641_ EDLSG 646_ TQFVC 651_ ETVIR 656_ SLTLD 661_ AAPDH 666_ NPPCR 671_ QKSLQ 676_ MTFAL 681_ PEGPL 686_ GNEKE 691_ EIIHI 696_ AEEEA 701_ VMEEE 706_ EDEED 711_ EEEED 716_ ELKDE 721_ VQSQS 726_ SASSE 731_ DYIII 736_ LPECF 741_ DTSRP 746_ LGDSM 751_ YSSAL 756_ SQPGL 761_ ERGAE 766_ GKPGV 771_ EAGQE 776_ PAEAG 781_ ERLPG 786_ GENQP 791_ QEHSI 796_ SDILT 801_ TSQTL 806_ ETVPL 811_ IPEVV 816_ ELPPS 821_ LPRSS 826_ PCVHH 831_ HGSPG 836_ VDLPV 841_ TIPEV 846_ SSVPD 851_ QIRGE 856_ PRGSS 861_ GLVNS 866_ RQKSY 871_ DHSRH 876_ HHGSS 881_ IAGGL 886_ VKGAL 891_ SVAAS 896_ AYKAL 901_ FAGPP 906_ VTAQP 911_ IISED 916_ QTAAL 921_ MAHLF 926_ EMGFC 931_ DRQLN 936_ LRLLK 941_ KHNYN 946_ ILQVV 951_ TELLQ 956_ LNNND 961_WYSQR
1: Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis (PubMed:24692539, PubMed:33577621). Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates (PubMed:24879152, PubMed:34471133). Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (PubMed:35914352). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity). Also plays non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity)