Indian hedgehog protein (IHH) (HHG-2) [Cleaved into: Indian hedgehog protein N-product; Indian hedgehog protein C-product]
1_MSPAR 6_ LRPRL 11_ HFCLV 16_ LLLLL 21_ VVPAA 26_ WGCGP 31_ GRVVG 36_ SRRRP 41_ PRKLV 46_ PLAYK 51_ QFSPN 56_ VPEKT 61_ LGASG 66_ RYEGK 71_ IARSS 76_ ERFKE 81_ LTPNY 86_ NPDII 91_ FKDEE 96_ NTGAD 101_ RLMTQ 106_ RCKDR 111_ LNSLA 116_ ISVMN 121_ QWPGV 126_ KLRVT 131_ EGWDE 136_ DGHHS 141_ EESLH 146_ YEGRA 151_ VDITT 156_ SDRDR 161_ NKYGL 166_ LARLA 171_ VEAGF 176_ DWVYY 181_ ESKAH 186_ VHCSV 191_ KSEHS 196_ AAAKT 201_ GGCFP 206_ AGAQV 211_ RLESG 216_ ARVAL 221_ SAVRP 226_ GDRVL 231_ AMGED 236_ GSPTF 241_ SDVLI 246_ FLDRE 251_ PHRLR 256_ AFQVI 261_ ETQDP 266_ PRRLA 271_ LTPAH 276_ LLFTA 281_ DNHTE 286_ PAARF 291_ RATFA 296_ SHVQP 301_ GQYVL 306_ VAGVP 311_ GLQPA 316_ RVAAV 321_ STHVA 326_ LGAYA 331_ PLTKH 336_ GTLVV 341_ EDVVA 346_ SCFAA 351_ VADHH 356_ LAQLA 361_ FWPLR 366_ LFHSL 371_ AWGSW 376_ TPGEG 381_ VHWYP 386_ QLLYR 391_ LGRLL 396_ LEEGS 401_ FHPLG 406_MSGAG
1: Plays a role in embryonic morphogenesis; it is involved in the regulation of endochondral skeleton formation, and the development of retinal pigment epithelium (RPE), photoreceptors and periocular tissues (By similarity)
2: The C-terminal part of the indian hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product (By similarity). Both activities occur in the endoplasmic reticulum (By similarity). Plays a role in hedgehog paracrine signaling (PubMed:24342078). Associated with the very-low-density lipoprotein (VLDL) particles to function as a circulating morphogen for endothelial cell integrity maintenance (PubMed:20839884)
3: The dually lipidated indian hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development. Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes (By similarity). Plays a role in morphogenesis of the skeleton by coordinating growth and differentiation of the endochondral skeleton (By similarity). Positively regulates PTHLH expression during endochondral bone formation preventing chondrocyte hypertrophy. In contrast, participates in normal chondrocyte proliferation in a PTHLH-independent pathway (By similarity)