Interleukin-11 receptor subunit alpha (IL-11 receptor subunit alpha) (IL-11R subunit alpha) (IL-11R-alpha) (IL-11RA) [Cleaved into: Soluble interleukin-11 receptor subunit alpha (sIL-11R) (sIL-11RA) (sIL11RA)]
1_MSSSC 6_ SGLSR 11_ VLVAV 16_ ATALV 21_ SASSP 26_ CPQAW 31_ GPPGV 36_ QYGQP 41_ GRSVK 46_ LCCPG 51_ VTAGD 56_ PVSWF 61_ RDGEP 66_ KLLQG 71_ PDSGL 76_ GHELV 81_ LAQAD 86_ STDEG 91_ TYICQ 96_ TLDGA 101_ LGGTV 106_ TLQLG 111_ YPPAR 116_ PVVSC 121_ QAADY 126_ ENFSC 131_ TWSPS 136_ QISGL 141_ PTRYL 146_ TSYRK 151_ KTVLG 156_ ADSQR 161_ RSPST 166_ GPWPC 171_ PQDPL 176_ GAARC 181_ VVHGA 186_ EFWSQ 191_ YRINV 196_ TEVNP 201_ LGAST 206_ RLLDV 211_ SLQSI 216_ LRPDP 221_ PQGLR 226_ VESVP 231_ GYPRR 236_ LRASW 241_ TYPAS 246_ WPCQP 251_ HFLLK 256_ FRLQY 261_ RPAQH 266_ PAWST 271_ VEPAG 276_ LEEVI 281_ TDAVA 286_ GLPHA 291_ VRVSA 296_ RDFLD 301_ AGTWS 306_ TWSPE 311_ AWGTP 316_ STGTI 321_ PKEIP 326_ AWGQL 331_ HTQPE 336_ VEPQV 341_ DSPAP 346_ PRPSL 351_ QPHPR 356_ LLDHR 361_ DSVEQ 366_ VAVLA 371_ SLGIL 376_ SFLGL 381_ VAGAL 386_ ALGLW 391_ LRLRR 396_ GGKDG 401_ SPKPG 406_ FLASV 411_ IPVDR 416_RPGAP
1: Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable). Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number
2: Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity (PubMed:26876177, PubMed:30279168). The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling (PubMed:26876177, PubMed:30279168)
3: Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity (PubMed:26876177, PubMed:30279168). The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling (PubMed:26876177, PubMed:30279168)