Gene name: IL13RA2

Uniprot entry:

Q14627

Protein names:

Interleukin-13 receptor subunit alpha-2 (IL-13 receptor subunit alpha-2) (IL-13R subunit alpha-2) (IL-13R-alpha-2) (IL-13RA2) (Interleukin-13-binding protein) (CD antigen CD213a2)

Protein sequence:

1_MAFVC 6_ LAIGC 11_ LYTFL 16_ ISTTF 21_ GCTSS 26_ SDTEI 31_ KVNPP 36_ QDFEI 41_ VDPGY 46_ LGYLY 51_ LQWQP 56_ PLSLD 61_ HFKEC 66_ TVEYE 71_ LKYRN 76_ IGSET 81_ WKTII 86_ TKNLH 91_ YKDGF 96_ DLNKG 101_ IEAKI 106_ HTLLP 111_ WQCTN 116_ GSEVQ 121_ SSWAE 126_ TTYWI 131_ SPQGI 136_ PETKV 141_ QDMDC 146_ VYYNW 151_ QYLLC 156_ SWKPG 161_ IGVLL 166_ DTNYN 171_ LFYWY 176_ EGLDH 181_ ALQCV 186_ DYIKA 191_ DGQNI 196_ GCRFP 201_ YLEAS 206_ DYKDF 211_ YICVN 216_ GSSEN 221_ KPIRS 226_ SYFTF 231_ QLQNI 236_ VKPLP 241_ PVYLT 246_ FTRES 251_ SCEIK 256_ LKWSI 261_ PLGPI 266_ PARCF 271_ DYEIE 276_ IREDD 281_ TTLVT 286_ ATVEN 291_ ETYTL 296_ KTTNE 301_ TRQLC 306_ FVVRS 311_ KVNIY 316_ CSDDG 321_ IWSEW 326_ SDKQC 331_ WEGED 336_ LSKKT 341_ LLRFW 346_ LPFGF 351_ ILILV 356_ IFVTG 361_ LLLRK 366_ PNTYP 371_KMIPE

Protein annotations

Protein functions:

1: Cell surface receptor that plays a role in the regulation of IL-13-mediated responses (PubMed:11861389, PubMed:17030238). Functions as a decoy receptor that inhibits IL-13- and IL-4-mediated signal transduction via the JAK-STAT pathway and thereby modulates immune responses and inflammation (PubMed:11861389, PubMed:17030238). Serves as a functional signaling receptor for IL-13 in an alternative pathway involving AP-1 ultimately leading to the production of TGFB1 (PubMed:16327802)