Inositol 1,4,5-trisphosphate receptor type 1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor)
1_MSDKM 6_ SSFLH 11_ IGDIC 16_ SLYAE 21_ GSTNG 26_ FISTL 31_ GLVDD 36_ RCVVQ 41_ PETGD 46_ LNNPP 51_ KKFRD 56_ CLFKL 61_ CPMNR 66_ YSAQK 71_ QFWKA 76_ AKPGA 81_ NSTTD 86_ AVLLN 91_ KLHHA 96_ ADLEK 101_ KQNET 106_ ENRKL 111_ LGTVI 116_ QYGNV 121_ IQLLH 126_ LKSNK 131_ YLTVN 136_ KRLPA 141_ LLEKN 146_ AMRVT 151_ LDEAG 156_ NEGSW 161_ FYIQP 166_ FYKLR 171_ SIGDS 176_ VVIGD 181_ KVVLN 186_ PVNAG 191_ QPLHA 196_ SSHQL 201_ VDNPG 206_ CNEVN 211_ SVNCN 216_ TSWKI 221_ VLFMK 226_ WSDNK 231_ DDILK 236_ GGDVV 241_ RLFHA 246_ EQEKF 251_ LTCDE 256_ HRKKQ 261_ HVFLR 266_ TTGRQ 271_ SATSA 276_ TSSKA 281_ LWEVE 286_ VVQHD 291_ PCRGG 296_ AGYWN 301_ SLFRF 306_ KHLAT 311_ GHYLA 316_ AEVDP 321_ DFEEE 326_ CLEFQ 331_ PSVDP 336_ DQDAS 341_ RSRLR 346_ NAQEK 351_ MVYSL 356_ VSVPE 361_ GNDIS 366_ SIFEL 371_ DPTTL 376_ RGGDS 381_ LVPRN 386_ SYVRL 391_ RHLCT 396_ NTWVH 401_ STNIP 406_ IDKEE 411_ EKPVM 416_ LKIGT 421_ SPVKE 426_ DKEAF 431_ AIVPV 436_ SPAEV 441_ RDLDF 446_ ANDAS 451_ KVLGS 456_ IAGKL 461_ EKGTI 466_ TQNER 471_ RSVTK 476_ LLEDL 481_ VYFVT 486_ GGTNS 491_ GQDVL 496_ EVVFS 501_ KPNRE 506_ RQKLM 511_ REQNI 516_ LKQIF 521_ KLLQA 526_ PFTDC 531_ GDGPM 536_ LRLEE 541_ LGDQR 546_ HAPFR 551_ HICRL 556_ CYRVL 561_ RHSQQ 566_ DYRKN 571_ QEYIA 576_ KQFGF 581_ MQKQI 586_ GYDVL 591_ AEDTI 596_ TALLH 601_ NNRKL 606_ LEKHI 611_ TAAEI 616_ DTFVS 621_ LVRKN 626_ REPRF 631_ LDYLS 636_ DLCVS 641_ MNKSI 646_ PVTQE 651_ LICKA 656_ VLNPT 661_ NADIL 666_ IETKL 671_ VLSRF 676_ EFEGV 681_ SSTGE 686_ NALEA 691_ GEDEE 696_ EVWLF 701_ WRDSN 706_ KEIRS 711_ KSVRE 716_ LAQDA 721_ KEGQK 726_ EDRDV 731_ LSYYR 736_ YQLNL 741_ FARMC 746_ LDRQY 751_ LAINE 756_ ISGQL 761_ DVDLI 766_ LRCMS 771_ DENLP 776_ YDLRA 781_ SFCRL 786_ MLHMH 791_ VDRDP 796_ QEQVT 801_ PVKYA 806_ RLWSE 811_ IPSEI 816_ AIDDY 821_ DSSGA 826_ SKDEI 831_ KERFA 836_ QTMEF 841_ VEEYL 846_ RDVVC 851_ QRFPF 856_ SDKEK 861_ NKLTF 866_ EVVNL 871_ ARNLI 876_ YFGFY 881_ NFSDL 886_ LRLTK 891_ ILLAI 896_ LDCVH 901_ VTTIF 906_ PISKM 911_ AKGEE 916_ NKGNN 921_ DVEKL 926_ KSSNV 931_ MRSIH 936_ GVGEL 941_ MTQVV 946_ LRGGG 951_ FLPMT 956_ PMAAA 961_ PEGNV 966_ KQAEP 971_ EKEDI 976_ MVMDT 981_ KLKII 986_ EILQF 991_ ILNVR 996_ LDYRI 1001_ SCLLC 1006_ IFKRE 1011_ FDESN 1016_ SQTSE 1021_ TSSGN 1026_ SSQEG 1031_ PSNVP 1036_ GALDF 1041_ EHIEE 1046_ QAEGI 1051_ FGGSE 1056_ ENTPL 1061_ DLDDH 1066_ GGRTF 1071_ LRVLL 1076_ HLTMH 1081_ DYPPL 1086_ VSGAL 1091_ QLLFR 1096_ HFSQR 1101_ QEVLQ 1106_ AFKQV 1111_ QLLVT 1116_ SQDVD 1121_ NYKQI 1126_ KQDLD 1131_ QLRSI 1136_ VEKSE 1141_ LWVYK 1146_ GQGPD 1151_ ETMDG 1156_ ASGEN 1161_ EHKKT 1166_ EEGNN 1171_ KPQKH 1176_ ESTSS 1181_ YNYRV 1186_ VKEIL 1191_ IRLSK 1196_ LCVQE 1201_ SASVR 1206_ KSRKQ 1211_ QQRLL 1216_ RNMGA 1221_ HAVVL 1226_ ELLQI 1231_ PYEKA 1236_ EDTKM 1241_ QEIMR 1246_ LAHEF 1251_ LQNFC 1256_ AGNQQ 1261_ NQALL 1266_ HKHIN 1271_ LFLNP 1276_ GILEA 1281_ VTMQH 1286_ IFMNN 1291_ FQLCS 1296_ EINER 1301_ VVQHF 1306_ VHCIE 1311_ THGRN 1316_ VQYIK 1321_ FLQTI 1326_ VKAEG 1331_ KFIKK 1336_ CQDMV 1341_ MAELV 1346_ NSGED 1351_ VLVFY 1356_ NDRAS 1361_ FQTLI 1366_ QMMRS 1371_ ERDRM 1376_ DENSP 1381_ LMYHI 1386_ HLVEL 1391_ LAVCT 1396_ EGKNV 1401_ YTEIK 1406_ CNSLL 1411_ PLDDI 1416_ VRVVT 1421_ HEDCI 1426_ PEVKI 1431_ AYINF 1436_ LNHCY 1441_ VDTEV 1446_ EMKEI 1451_ YTSNH 1456_ MWKLF 1461_ ENFLV 1466_ DICRA 1471_ CNNTS 1476_ DRKHA 1481_ DSILE 1486_ KYVTE 1491_ IVMSI 1496_ VTTFF 1501_ SSPFS 1506_ DQSTT 1511_ LQTRQ 1516_ PVFVQ 1521_ LLQGV 1526_ FRVYH 1531_ CNWLM 1536_ PSQKA 1541_ SVESC 1546_ IRVLS 1551_ DVAKS 1556_ RAIAI 1561_ PVDLD 1566_ SQVNN 1571_ LFLKS 1576_ HSIVQ 1581_ KTAMN 1586_ WRLSA 1591_ RNAAR 1596_ RDSVL 1601_ AASRD 1606_ YRNII 1611_ ERLQD 1616_ IVSAL 1621_ EDRLR 1626_ PLVQA 1631_ ELSVL 1636_ VDVLH 1641_ RPELL 1646_ FPENT 1651_ DARRK 1656_ CESGG 1661_ FICKL 1666_ IKHTK 1671_ QLLEE 1676_ NEEKL 1681_ CIKVL 1686_ QTLRE 1691_ MMTKD 1696_ RGYGE 1701_ KLISI 1706_ DELDN 1711_ AELPP 1716_ APDSE 1721_ NATEE 1726_ LEPSP 1731_ PLRQL 1736_ EDHKR 1741_ GEALR 1746_ QVLVN 1751_ RYYGN 1756_ VRPSG 1761_ RRESL 1766_ TSFGN 1771_ GPLSA 1776_ GGPGK 1781_ PGGGG 1786_ GGSGS 1791_ SSMSR 1796_ GEMSL 1801_ AEVQC 1806_ HLDKE 1811_ GASNL 1816_ VIDLI 1821_ MNASS 1826_ DRVFH 1831_ ESILL 1836_ AIALL 1841_ EGGNT 1846_ TIQHS 1851_ FFCRL 1856_ TEDKK 1861_ SEKFF 1866_ KVFYD 1871_ RMKVA 1876_ QQEIK 1881_ ATVTV 1886_ NTSDL 1891_ GNKKK 1896_ DDEVD 1901_ RDAPS 1906_ RKKAK 1911_ EPTTQ 1916_ ITEEV 1921_ RDQLL 1926_ EASAA 1931_ TRKAF 1936_ TTFRR 1941_ EADPD 1946_ DHYQP 1951_ GEGTQ 1956_ ATADK 1961_ AKDDL 1966_ EMSAV 1971_ ITIMQ 1976_ PILRF 1981_ LQLLC 1986_ ENHNR 1991_ DLQNF 1996_ LRCQN 2001_ NKTNY 2006_ NLVCE 2011_ TLQFL 2016_ DCICG 2021_ STTGG 2026_ LGLLG 2031_ LYINE 2036_ KNVAL 2041_ INQTL 2046_ ESLTE 2051_ YCQGP 2056_ CHENQ 2061_ NCIAT 2066_ HESNG 2071_ IDIIT 2076_ ALILN 2081_ DINPL 2086_ GKKRM 2091_ DLVLE 2096_ LKNNA 2101_ SKLLL 2106_ AIMES 2111_ RHDSE 2116_ NAERI 2121_ LYNMR 2126_ PKELV 2131_ EVIKK 2136_ AYMQG 2141_ EVEFE 2146_ DGENG 2151_ EDGAA 2156_ SPRNV 2161_ GHNIY 2166_ ILAHQ 2171_ LARHN 2176_ KELQS 2181_ MLKPG 2186_ GQVDG 2191_ DEALE 2196_ FYAKH 2201_ TAQIE 2206_ IVRLD 2211_ RTMEQ 2216_ IVFPV 2221_ PSICE 2226_ FLTKE 2231_ SKLRI 2236_ YYTTE 2241_ RDEQG 2246_ SKIND 2251_ FFLRS 2256_ EDLFN 2261_ EMNWQ 2266_ KKLRA 2271_ QPVLY 2276_ WCARN 2281_ MSFWS 2286_ SISFN 2291_ LAVLM 2296_ NLLVA 2301_ FFYPF 2306_ KGVRG 2311_ GTLEP 2316_ HWSGL 2321_ LWTAM 2326_ LISLA 2331_ IVIAL 2336_ PKPHG 2341_ IRALI 2346_ ASTIL 2351_ RLIFS 2356_ VGLQP 2361_ TLFLL 2366_ GAFNV 2371_ CNKII 2376_ FLMSF 2381_ VGNCG 2386_ TFTRG 2391_ YRAMV 2396_ LDVEF 2401_ LYHLL 2406_ YLVIC 2411_ AMGLF 2416_ VHEFF 2421_ YSLLL 2426_ FDLVY 2431_ REETL 2436_ LNVIK 2441_ SVTRN 2446_ GRSII 2451_ LTAVL 2456_ ALILV 2461_ YLFSI 2466_ VGYLF 2471_ FKDDF 2476_ ILEVD 2481_ RLPNE 2486_ TAVPE 2491_ TGESL 2496_ ASEFL 2501_ FSDVC 2506_ RVESG 2511_ ENCSS 2516_ PAPRE 2521_ ELVPA 2526_ EETEQ 2531_ DKEHT 2536_ CETLL 2541_ MCIVT 2546_ VLSHG 2551_ LRSGG 2556_ GVGDV 2561_ LRKPS 2566_ KEEPL 2571_ FAARV 2576_ IYDLL 2581_ FFFMV 2586_ IIIVL 2591_ NLIFG 2596_ VIIDT 2601_ FADLR 2606_ SEKQK 2611_ KEEIL 2616_ KTTCF 2621_ ICGLE 2626_ RDKFD 2631_ NKTVT 2636_ FEEHI 2641_ KEEHN 2646_ MWHYL 2651_ CFIVL 2656_ VKVKD 2661_ STEYT 2666_ GPESY 2671_ VAEMI 2676_ KERNL 2681_ DWFPR 2686_ MRAMS 2691_ LVSSD 2696_ SEGEQ 2701_ NELRN 2706_ LQEKL 2711_ ESTMK 2716_ LVTNL 2721_ SGQLS 2726_ ELKDQ 2731_ MTEQR 2736_ KQKQR 2741_ IGLLG 2746_ HPPHM 2751_NVNPQ
1: Inositol 1,4,5-trisphosphate-gated calcium channel that, upon inositol 1,4,5-trisphosphate binding, mediates calcium release from the endoplasmic reticulum (ER) (PubMed:10620513, PubMed:27108797). Undergoes conformational changes upon ligand binding, suggesting structural flexibility that allows the channel to switch from a closed state, capable of interacting with its ligands such as 1,4,5-trisphosphate and calcium, to an open state, capable of transferring calcium ions across the ER membrane (By similarity). Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CAMK2 complex (By similarity). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Regulates fertilization and egg activation by tuning the frequency and amplitude of calcium oscillations (By similarity)