Interferon regulatory factor 3 (IRF-3)
1_MGTPK 6_ PRILP 11_ WLVSQ 16_ LDLGQ 21_ LEGVA 26_ WVNKS 31_ RTRFR 36_ IPWKH 41_ GLRQD 46_ AQQED 51_ FGIFQ 56_ AWAEA 61_ TGAYV 66_ PGRDK 71_ PDLPT 76_ WKRNF 81_ RSALN 86_ RKEGL 91_ RLAED 96_ RSKDP 101_ HDPHK 106_ IYEFV 111_ NSGVG 116_ DFSQP 121_ DTSPD 126_ TNGGG 131_ STSDT 136_ QEDIL 141_ DELLG 146_ NMVLA 151_ PLPDP 156_ GPPSL 161_ AVAPE 166_ PCPQP 171_ LRSPS 176_ LDNPT 181_ PFPNL 186_ GPSEN 191_ PLKRL 196_ LVPGE 201_ EWEFE 206_ VTAFY 211_ RGRQV 216_ FQQTI 221_ SCPEG 226_ LRLVG 231_ SEVGD 236_ RTLPG 241_ WPVTL 246_ PDPGM 251_ SLTDR 256_ GVMSY 261_ VRHVL 266_ SCLGG 271_ GLALW 276_ RAGQW 281_ LWAQR 286_ LGHCH 291_ TYWAV 296_ SEELL 301_ PNSGH 306_ GPDGE 311_ VPKDK 316_ EGGVF 321_ DLGPF 326_ IVDLI 331_ TFTEG 336_ SGRSP 341_ RYALW 346_ FCVGE 351_ SWPQD 356_ QPWTK 361_ RLVMV 366_ KVVPT 371_ CLRAL 376_ VEMAR 381_ VGGAS 386_ SLENT 391_ VDLHI 396_ SNSHP 401_ LSLTS 406_ DQYKA 411_ YLQDL 416_ VEGMD 421_FQGPG
1: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:24049179, PubMed:25636800, PubMed:27302953, PubMed:31340999, PubMed:36603579, PubMed:8524823). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995, PubMed:36603579, PubMed:8524823). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:36603579). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953, PubMed:36603579). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953, PubMed:33440148, PubMed:36603579). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591). In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148)