ATP-sensitive inward rectifier potassium channel 11 (IKATP) (Inward rectifier K(+) channel Kir6.2) (Potassium channel, inwardly rectifying subfamily J member 11)
1_MLSRK 6_ GIIPE 11_ EYVLT 16_ RLAED 21_ PAKPR 26_ YRARQ 31_ RRARF 36_ VSKKG 41_ NCNVA 46_ HKNIR 51_ EQGRF 56_ LQDVF 61_ TTLVD 66_ LKWPH 71_ TLLIF 76_ TMSFL 81_ CSWLL 86_ FAMAW 91_ WLIAF 96_ AHGDL 101_ APSEG 106_ TAEPC 111_ VTSIH 116_ SFSSA 121_ FLFSI 126_ EVQVT 131_ IGFGG 136_ RMVTE 141_ ECPLA 146_ ILILI 151_ VQNIV 156_ GLMIN 161_ AIMLG 166_ CIFMK 171_ TAQAH 176_ RRAET 181_ LIFSK 186_ HAVIA 191_ LRHGR 196_ LCFML 201_ RVGDL 206_ RKSMI 211_ ISATI 216_ HMQVV 221_ RKTTS 226_ PEGEV 231_ VPLHQ 236_ VDIPM 241_ ENGVG 246_ GNSIF 251_ LVAPL 256_ IIYHV 261_ IDANS 266_ PLYDL 271_ APSDL 276_ HHHQD 281_ LEIIV 286_ ILEGV 291_ VETTG 296_ ITTQA 301_ RTSYL 306_ ADEIL 311_ WGQRF 316_ VPIVA 321_ EEDGR 326_ YSVDY 331_ SKFGN 336_ TVKVP 341_ TPLCT 346_ ARQLD 351_ EDHSL 356_ LEALT 361_ LASAR 366_ GPLRK 371_ RSVPM 376_ AKAKP 381_KFSIS
1: Inward rectifier potassium channel that forms the pore of ATP-sensitive potassium channels (KATP), regulating potassium permeability as a function of cytoplasmic ATP and ADP concentrations in many different cells (PubMed:29286281, PubMed:34815345). Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). In pancreatic cells, it forms KATP channels with ABCC8/SUR1 (PubMed:29286281, PubMed:34815345). Can form cardiac and smooth muscle-type KATP channels with ABCC9