EKC/KEOPS complex subunit LAGE3 (L antigen family member 3) (Protein ESO-3) (Protein ITBA2)
1_MRDAD 6_ ADAGG 11_ GADGG 16_ DGRGG 21_ HSCRG 26_ GVDTA 31_ AAPAG 36_ GAPPA 41_ HAPGP 46_ GRDAA 51_ SAARG 56_ SRMRP 61_ HIFTL 66_ SVPFP 71_ TPLEA 76_ EIAHG 81_ SLAPD 86_ AEPHQ 91_ RVVGK 96_ DLTVS 101_ GRILV 106_ VRWKA 111_ EDCRL 116_ LRISV 121_ INFLD 126_ QLSLV 131_ VRTMQ 136_RFGPP
1: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914). LAGE3 functions as a dimerization module for the complex (PubMed:22912744, PubMed:27903914)