Pumilio homolog 1 (HsPUM) (Pumilio-1)
1_MSVAC 6_ VLKRK 11_ AVLWQ 16_ DSFSP 21_ HLKHH 26_ PQEPA 31_ NPNMP 36_ VVLTS 41_ GTGSQ 46_ AQPQP 51_ AANQA 56_ LAAGT 61_ HSSPV 66_ PGSIG 71_ VAGRS 76_ QDDAM 81_ VDYFF 86_ QRQHG 91_ EQLGG 96_ GGSGG 101_ GGYNN 106_ SKHRW 111_ PTGDN 116_ IHAEH 121_ QVRSM 126_ DELNH 131_ DFQAL 136_ ALEGR 141_ AMGEQ 146_ LLPGK 151_ KFWET 156_ DESSK 161_ DGPKG 166_ IFLGD 171_ QWRDS 176_ AWGTS 181_ DHSVS 186_ QPIMV 191_ QRRPG 196_ QSFHV 201_ NSEVN 206_ SVLSP 211_ RSESG 216_ GLGVS 221_ MVEYV 226_ LSSSP 231_ GDSCL 236_ RKGGF 241_ GPRDA 246_ DSDEN 251_ DKGEK 256_ KNKGT 261_ FDGDK 266_ LGDLK 271_ EEGDV 276_ MDKTN 281_ GLPVQ 286_ NGIDA 291_ DVKDF 296_ SRTPG 301_ NCQNS 306_ ANEVD 311_ LLGPN 316_ QNGSE 321_ GLAQL 326_ TSTNG 331_ AKPVE 336_ DFSNM 341_ ESQSV 346_ PLDPM 351_ EHVGM 356_ EPLQF 361_ DYSGT 366_ QVPVD 371_ SAAAT 376_ VGLFD 381_ YNSQQ 386_ QLFQR 391_ PNALA 396_ VQQLT 401_ AAQQQ 406_ QYALA 411_ AAHQP 416_ HIGLA 421_ PAAFV 426_ PNPYI 431_ ISAAP 436_ PGTDP 441_ YTAGL 446_ AAAAT 451_ LGPAV 456_ VPHQY 461_ YGVTP 466_ WGVYP 471_ ASLFQ 476_ QQAAA 481_ AAAAT 486_ NSANQ 491_ QTTPQ 496_ AQQGQ 501_ QQVLR 506_ GGASQ 511_ RPLTP 516_ NQNQQ 521_ GQQTD 526_ PLVAA 531_ AAVNS 536_ ALAFG 541_ QGLAA 546_ GMPGY 551_ PVLAP 556_ AAYYD 561_ QTGAL 566_ VVNAG 571_ ARNGL 576_ GAPVR 581_ LVAPA 586_ PVIIS 591_ SSAAQ 596_ AAVAA 601_ AAASA 606_ NGAAG 611_ GLAGT 616_ TNGPF 621_ RPLGT 626_ QQPQP 631_ QPQQQ 636_ PNNNL 641_ ASSSF 646_ YGNNS 651_ LNSNS 656_ QSSSL 661_ FSQGS 666_ AQPAN 671_ TSLGF 676_ GSSSS 681_ LGATL 686_ GSALG 691_ GFGTA 696_ VANSN 701_ TGSGS 706_ RRDSL 711_ TGSSD 716_ LYKRT 721_ SSSLT 726_ PIGHS 731_ FYNGL 736_ SFSSS 741_ PGPVG 746_ MPLPS 751_ QGPGH 756_ SQTPP 761_ PSLSS 766_ HGSSS 771_ SLNLG 776_ GLTNG 781_ SGRYI 786_ SAAPG 791_ AEAKY 796_ RSASS 801_ ASSLF 806_ SPSST 811_ LFSSS 816_ RLRYG 821_ MSDVM 826_ PSGRS 831_ RLLED 836_ FRNNR 841_ YPNLQ 846_ LREIA 851_ GHIME 856_ FSQDQ 861_ HGSRF 866_ IQLKL 871_ ERATP 876_ AERQL 881_ VFNEI 886_ LQAAY 891_ QLMVD 896_ VFGNY 901_ VIQKF 906_ FEFGS 911_ LEQKL 916_ ALAER 921_ IRGHV 926_ LSLAL 931_ QMYGC 936_ RVIQK 941_ ALEFI 946_ PSDQQ 951_ NEMVR 956_ ELDGH 961_ VLKCV 966_ KDQNG 971_ NHVVQ 976_ KCIEC 981_ VQPQS 986_ LQFII 991_ DAFKG 996_ QVFAL 1001_ STHPY 1006_ GCRVI 1011_ QRILE 1016_ HCLPD 1021_ QTLPI 1026_ LEELH 1031_ QHTEQ 1036_ LVQDQ 1041_ YGNYV 1046_ IQHVL 1051_ EHGRP 1056_ EDKSK 1061_ IVAEI 1066_ RGNVL 1071_ VLSQH 1076_ KFASN 1081_ VVEKC 1086_ VTHAS 1091_ RTERA 1096_ VLIDE 1101_ VCTMN 1106_ DGPHS 1111_ ALYTM 1116_ MKDQY 1121_ ANYVV 1126_ QKMID 1131_ VAEPG 1136_ QRKIV 1141_ MHKIR 1146_ PHIAT 1151_ LRKYT 1156_ YGKHI 1161_ LAKLE 1166_ KYYMK 1171_ NGVDL 1176_ GPICG 1181_PPNGI
1: Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (PubMed:18328718, PubMed:21397187, PubMed:21572425, PubMed:21653694). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:20818387, PubMed:20860814, PubMed:22345517). Following growth factor stimulation, phosphorylated and binds to the 3'-UTR of CDKN1B/p27 mRNA, inducing a local conformational change that exposes miRNA-binding sites, promoting association of miR-221 and miR-222, efficient suppression of CDKN1B/p27 expression, and rapid entry to the cell cycle (PubMed:20818387). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517, PubMed:29474920). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). Involved in neuronal functions by regulating ATXN1 mRNA levels: acts by binding to the 3'-UTR of ATXN1 transcripts, leading to their down-regulation independently of the miRNA machinery (PubMed:25768905, PubMed:29474920). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). In testis, acts as a post-transcriptional regulator of spermatogenesis by binding to the 3'-UTR of mRNAs coding for regulators of p53/TP53. Involved in embryonic stem cell renewal by facilitating the exit from the ground state: acts by targeting mRNAs coding for naive pluripotency transcription factors and accelerates their down-regulation at the onset of differentiation (By similarity). Binds specifically to miRNA MIR199A precursor, with PUM2, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233)