Separin (EC 3.4.22.49) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein) (Separase)
1_MRSFK 6_ RVNFG 11_ TLLSS 16_ QKEAE 21_ ELLPA 26_ LKEFL 31_ SNPPA 36_ GFPSS 41_ RSDAE 46_ RRQAC 51_ DAILR 56_ ACNQQ 61_ LTAKL 66_ ACPRH 71_ LGSLL 76_ ELAEL 81_ ACDGY 86_ LVSTP 91_ QRPPL 96_ YLERI 101_ LFVLL 106_ RNAAA 111_ QGSPE 116_ ATLRL 121_ AQPLH 126_ ACLVQ 131_ CSREA 136_ APQDY 141_ EAVAR 146_ GSFSL 151_ LWKGA 156_ EALLE 161_ RRAAF 166_ AARLK 171_ ALSFL 176_ VLLED 181_ ESTPC 186_ EVPHF 191_ ASPTA 196_ CRAVA 201_ AHQLF 206_ DASGH 211_ GLNEA 216_ DADFL 221_ DDLLS 226_ RHVIR 231_ ALVGE 236_ RGSSS 241_ GLLSP 246_ QRALC 251_ LLELT 256_ LEHCR 261_ RFCWS 266_ RHHDK 271_ AISAV 276_ EKAHS 281_ YLRNT 286_ NLAPS 291_ LQLCQ 296_ LGVKL 301_ LQVGE 306_ EGPQA 311_ VAKLL 316_ IKASA 321_ VLSKS 326_ MEAPS 331_ PPLRA 336_ LYESC 341_ QFFLS 346_ GLERG 351_ TKRRY 356_ RLDAI 361_ LSLFA 366_ FLGGY 371_ CSLLQ 376_ QLRDD 381_ GVYGG 386_ SSKQQ 391_ QSFLQ 396_ MYFQG 401_ LHLYT 406_ VVVYD 411_ FAQGC 416_ QIVDL 421_ ADLTQ 426_ LVDSC 431_ KSTVV 436_ WMLEA 441_ LEGLS 446_ GQELT 451_ DHMGM 456_ TASYT 461_ SNLAY 466_ SFYSH 471_ KLYAE 476_ ACAIS 481_ EPLCQ 486_ HLGLV 491_ KPGTY 496_ PEVPP 501_ EKLHR 506_ CFRLQ 511_ VESLK 516_ KLGKQ 521_ AQGCK 526_ MVILW 531_ LAALQ 536_ PCSPE 541_ HMAEP 546_ VTFWV 551_ RVKMD 556_ AARAG 561_ DKELQ 566_ LKTLR 571_ DSLSG 576_ WDPET 581_ LALLL 586_ REELQ 591_ AYKAV 596_ RADTG 601_ QERFN 606_ IICDL 611_ LELSP 616_ EETPA 621_ GAWAR 626_ ATHLV 631_ ELAQV 636_ LCYHD 641_ FTQQT 646_ NCSAL 651_ DAIRE 656_ ALQLL 661_ DSVRP 666_ EAQAR 671_ DQLLD 676_ DKAQA 681_ LLWLY 686_ ICTLE 691_ AKMQE 696_ GIERD 701_ RRAQA 706_ PGNLE 711_ EFEVN 716_ DLNYE 721_ DKLQE 726_ DRFLY 731_ SNIAF 736_ NLAAD 741_ AAQSK 746_ CLDQA 751_ LALWK 756_ ELLTK 761_ GQAPA 766_ VRCLQ 771_ QTAAS 776_ LQILA 781_ ALYQL 786_ VAKPM 791_ QALEV 796_ LLLLR 801_ IVSER 806_ LKDHS 811_ KAAGS 816_ SCHIT 821_ QLLLT 826_ LGCPS 831_ YAQLH 836_ LEEAA 841_ SSLKH 846_ LDQTT 851_ DTYLL 856_ LSLTC 861_ DLLRS 866_ QLYWT 871_ HQKVT 876_ KGVSL 881_ LLSVL 886_ RDPAL 891_ QKSSK 896_ AWYLL 901_ RVQVL 906_ QLVAA 911_ YLSLP 916_ SNNLS 921_ HSLWE 926_ QLCAQ 931_ GWQTP 936_ EIALI 941_ DSHKL 946_ LRSII 951_ LLLMG 956_ SDILS 961_ TQKAA 966_ VETSF 971_ LDYGE 976_ NLVQK 981_ WQVLS 986_ EVLSC 991_ SEKLV 996_ CHLGR 1001_ LGSVS 1006_ EAKAF 1011_ CLEAL 1016_ KLTTK 1021_ LQIPR 1026_ QCALF 1031_ LVLKG 1036_ ELELA 1041_ RNDID 1046_ LCQSD 1051_ LQQVL 1056_ FLLES 1061_ CTEFG 1066_ GVTQH 1071_ LDSVK 1076_ KVHLQ 1081_ KGKQQ 1086_ AQVPC 1091_ PPQLP 1096_ EEELF 1101_ LRGPA 1106_ LELVA 1111_ TVAKE 1116_ PGPIA 1121_ PSTNS 1126_ SPVLK 1131_ TKPQP 1136_ IPNFL 1141_ SHSPT 1146_ CDCSL 1151_ CASPV 1156_ LTAVC 1161_ LRWVL 1166_ VTAGV 1171_ RLAMG 1176_ HQAQG 1181_ LDLLQ 1186_ VVLKG 1191_ CPEAA 1196_ ERLTQ 1201_ ALQAS 1206_ LNHKT 1211_ PPSLV 1216_ PSLLD 1221_ EILAQ 1226_ AYTLL 1231_ ALEGL 1236_ NQPSN 1241_ ESLQK 1246_ VLQSG 1251_ LKFVA 1256_ ARIPH 1261_ LEPWR 1266_ ASLLL 1271_ IWALT 1276_ KLGGL 1281_ SCCTT 1286_ QLFAS 1291_ SWGWQ 1296_ PPLIK 1301_ SVPGS 1306_ EPSKT 1311_ QGQKR 1316_ SGRGR 1321_ QKLAS 1326_ APLRL 1331_ NNTSQ 1336_ KGLEG 1341_ RGLPC 1346_ TPKPP 1351_ DRIRQ 1356_ AGPHV 1361_ PFTVF 1366_ EEVCP 1371_ TESKP 1376_ EVPQA 1381_ PRVQQ 1386_ RVQTR 1391_ LKVNF 1396_ SDDSD 1401_ LEDPV 1406_ SAEAW 1411_ LAEEP 1416_ KRRGT 1421_ ASRGR 1426_ GRARK 1431_ GLSLK 1436_ TDAVV 1441_ APGSA 1446_ PGNPG 1451_ LNGRS 1456_ RRAKK 1461_ VASRH 1466_ CEERR 1471_ PQRAS 1476_ DQARP 1481_ GPEIM 1486_ RTIPE 1491_ EELTD 1496_ NWRKM 1501_ SFEIL 1506_ RGSDG 1511_ EDSAS 1516_ GGKTP 1521_ APGPE 1526_ AASGE 1531_ WELLR 1536_ LDSSK 1541_ KKLPS 1546_ PCPDK 1551_ ESDKD 1556_ LGPRL 1561_ RLPSA 1566_ PVATG 1571_ LSTLD 1576_ SICDS 1581_ LSVAF 1586_ RGISH 1591_ CPPSG 1596_ LYAHL 1601_ CRFLA 1606_ LCLGH 1611_ RDPYA 1616_ TAFLV 1621_ TESVS 1626_ ITCRH 1631_ QLLTH 1636_ LHRQL 1641_ SKAQK 1646_ HRGSL 1651_ EIADQ 1656_ LQGLS 1661_ LQEMP 1666_ GDVPL 1671_ ARIQR 1676_ LFSFR 1681_ ALESG 1686_ HFPQP 1691_ EKESF 1696_ QERLA 1701_ LIPSG 1706_ VTVCV 1711_ LALAT 1716_ LQPGT 1721_ VGNTL 1726_ LLTRL 1731_ EKDSP 1736_ PVSVQ 1741_ IPTGQ 1746_ NKLHL 1751_ RSVLN 1756_ EFDAI 1761_ QKAQK 1766_ ENSSC 1771_ TDKRE 1776_ WWTGR 1781_ LALDH 1786_ RMEVL 1791_ IASLE 1796_ KSVLG 1801_ CWKGL 1806_ LLPSS 1811_ EEPGP 1816_ AQEAS 1821_ RLQEL 1826_ LQDCG 1831_ WKYPD 1836_ RTLLK 1841_ IMLSG 1846_ AGALT 1851_ PQDIQ 1856_ ALAYG 1861_ LCPTQ 1866_ PERAQ 1871_ ELLNE 1876_ AVGRL 1881_ QGLTV 1886_ PSNSH 1891_ LVLVL 1896_ DKDLQ 1901_ KLPWE 1906_ SMPSL 1911_ QALPV 1916_ TRLPS 1921_ FRFLL 1926_ SYSII 1931_ KEYGA 1936_ SPVLS 1941_ QGVDP 1946_ RSTFY 1951_ VLNPH 1956_ NNLSS 1961_ TEEQF 1966_ RANFS 1971_ SEAGW 1976_ RGVVG 1981_ EVPRP 1986_ EQVQE 1991_ ALTKH 1996_ DLYIY 2001_ AGHGA 2006_ GARFL 2011_ DGQAV 2016_ LRLSC 2021_ RAVAL 2026_ LFGCS 2031_ SAALA 2036_ VRGNL 2041_ EGAGI 2046_ VLKYI 2051_ MAGCP 2056_ LFLGN 2061_ LWDVT 2066_ DRDID 2071_ RYTEA 2076_ LLQGW 2081_ LGAGP 2086_ GAPLL 2091_ YYVNQ 2096_ ARQAP 2101_ RLKYL 2106_ IGAAP 2111_IAYGL
1: Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms