KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein)
1_MAHTT 6_ KVNGS 11_ ASGKA 16_ GDILS 21_ GDQDK 26_ EQKDP 31_ YFVET 36_ PYGYQ 41_ LDLDF 46_ LKYVD 51_ DIQKG 56_ NTIKR 61_ LNIQK 66_ RRKPS 71_ VPCPE 76_ PRTTS 81_ GQQGI 86_ WTSTE 91_ SLSSS 96_ NSDDN 101_ KQCPN 106_ FLIAR 111_ SQVTS 116_ TPISK 121_ PPPPL 126_ ETSLP 131_ FLTIP 136_ ENRQL 141_ PPPSP 146_ QLPKH 151_ NLHVT 156_ KTLME 161_ TRRRL 166_ EQERA 171_ TMQMT 176_ PGEFR 181_ RPRLA 186_ SFGGM 191_ GTTSS 196_ LPSFV 201_ GSGNH 206_ NPAKH 211_ QLQNG 216_ YQGNG 221_ DYGSY 226_ APAAP 231_ TTSSM 236_ GSSIR 241_ HSPLS 246_ SGIST 251_ PVTNV 256_ SPMHL 261_ QHIRE 266_ QMAIA 271_ LKRLK 276_ ELEEQ 281_ VRTIP 286_ VLQVK 291_ ISVLQ 296_ EEKRQ 301_ LVSQL 306_ KNQRA 311_ ASQIN 316_ VCGVR 321_ KRSYS 326_ AGNAS 331_ QLEQL 336_ SRARR 341_ SGGEL 346_ YIDYE 351_ EEEME 356_ TVEQS 361_ TQRIK 366_ EFRQL 371_ TADMQ 376_ ALEQK 381_ IQDSS 386_ CEASS 391_ ELREN 396_ GECRS 401_ VAVGA 406_ EENMN 411_ DIVVY 416_ HRGSR 421_ SCKDA 426_ AVGTL 431_ VEMRN 436_ CGVSV 441_ TEAML 446_ GVMTE 451_ ADKEI 456_ ELQQQ 461_ TIESL 466_ KEKIY 471_ RLEVQ 476_ LRETT 481_ HDREM 486_ TKLKQ 491_ ELQAA 496_ GSRKK 501_ VDKAT 506_ MAQPL 511_ VFSKV 516_ VEAVV 521_ QTRDQ 526_ MVGSH 531_ MDLVD 536_ TCVGT 541_ SVETN 546_ SVGIS 551_ CQPEC 556_ KNKVV 561_ GPELP 566_ MNWWI 571_ VKERV 576_ EMHDR 581_ CAGRS 586_ VEMCD 591_ KSVSV 596_ EVSVC 601_ ETGSN 606_ TEESV 611_ NDLTL 616_ LKTNL 621_ NLKEV 626_ RSIGC 631_ GDCSV 636_ DVTVC 641_ SPKEC 646_ ASRGV 651_ NTEAV 656_ SQVEA 661_ AVMAV 666_ PRTAD 671_ QDTST 676_ DLEQV 681_ HQFTN 686_ TETAT 691_ LIESC 696_ TNTCL 701_ STLDK 706_ QTSTQ 711_ TVETR 716_ TVAVG 721_ EGRVK 726_ DINSS 731_ TKTRS 736_ IGVGT 741_ LLSGH 746_ SGFDR 751_ PSAVK 756_ TKESG 761_ VGQIN 766_ INDNY 771_ LVGLK 776_ MRTIA 781_ CGPPQ 786_ LTVGL 791_ TASRR 796_ SVGVG 801_ DDPVG 806_ ESLEN 811_ PQPQA 816_ PLGMM 821_ TGLDH 826_ YIERI 831_ QKLLA 836_ EQQTL 841_ LAENY 846_ SELAE 851_ AFGEP 856_ HSQMG 861_ SLNSQ 866_ LISTL 871_ SSINS 876_ VMKSA 881_ STEEL 886_ RNPDF 891_ QKTSL 896_ GKITG 901_ NYLGY 906_ TCKCG 911_ GLQSG 916_ SPLSS 921_ QTSQP 926_ EQEVG 931_ TSEGK 936_ PISSL 941_ DAFPT 946_ QEGTL 951_ SPVNL 956_ TDDQI 961_ AAGLY 966_ ACTNN 971_ ESTLK 976_ SIMKK 981_ KDGNK 986_ DSNGA 991_ KKNLQ 996_ FVGIN 1001_ GGYET 1006_ TSSDD 1011_ SSSDE 1016_ SSSSE 1021_ SDDEC 1026_ DVIEY 1031_ PLEEE 1036_ EEEED 1041_ EDTRG 1046_ MAEGH 1051_ HAVNI 1056_ EGLKS 1061_ ARVED 1066_ EMQVQ 1071_ ECEPE 1076_ KVEIR 1081_ ERYEL 1086_ SEKML 1091_ SACNL 1096_ LKNTI 1101_ NDPKA 1106_ LTSKD 1111_ MRFCL 1116_ NTLQH 1121_ EWFRV 1126_ SSQKS 1131_ AIPAM 1136_ VGDYI 1141_ AAFEA 1146_ ISPDV 1151_ LRYVI 1156_ NLADG 1161_ NGNTA 1166_ LHYSV 1171_ SHSNF 1176_ EIVKL 1181_ LLDAD 1186_ VCNVD 1191_ HQNKA 1196_ GYTPI 1201_ MLAAL 1206_ AAVEA 1211_ EKDMR 1216_ IVEEL 1221_ FGCGD 1226_ VNAKA 1231_ SQAGQ 1236_ TALML 1241_ AVSHG 1246_ RIDMV 1251_ KGLLA 1256_ CGADV 1261_ NIQDD 1266_ EGSTA 1271_ LMCAS 1276_ EHGHV 1281_ EIVKL 1286_ LLAQP 1291_ GCNGH 1296_ LEDND 1301_ GSTAL 1306_ SIALE 1311_ AGHKD 1316_ IAVLL 1321_ YAHVN 1326_ FAKAQ 1331_ SPGTP 1336_ RLGRK 1341_ TSPGP 1346_THRGS
1: Adapter protein that links structural and signaling protein complexes positioned to guide microtubule and actin cytoskeleton dynamics during cell morphogenesis (PubMed:22084092, PubMed:24120883). At focal adhesions (FAs) rims, organizes cortical microtubule stabilizing complexes (CMSCs) and directly interacts with major FA component TLN1, forming macromolecular assemblies positioned to control microtubule-actin crosstalk at the cell edge (PubMed:24120883, PubMed:27410476). Recruits KIF21A in CMSCs at axonal growth cones and regulates axon guidance by suppressing microtubule growth without inducing microtubule disassembly once it reaches the cell cortex (PubMed:24120883). Interacts with ARFGEF1 and participates in establishing microtubule-organizing center (MTOC) orientation and directed cell movement in wound healing (PubMed:22084092). Regulates actin stress fiber formation and cell migration by inhibiting RHOA activation in response to growth factors; this function involves phosphorylation through PI3K/Akt signaling and may depend on the competitive interaction with 14-3-3 adapter proteins to sequester them from active complexes (PubMed:18458160, PubMed:25961457). Inhibits the formation of lamellipodia but not of filopodia; this function may depend on the competitive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; this function is partially mediated by BAIAP2 (PubMed:19171758). In the nucleus, is involved in beta-catenin-dependent activation of transcription (PubMed:16968744). During cell division, may regulate DAAM1-dependent RHOA activation that signals centrosome maturation and chromosomal segregation. May also be involved in contractile ring formation during cytokinesis (By similarity). Potential tumor suppressor for renal cell carcinoma (Probable)