Tubulin monoglutamylase TTLL4 (EC 6.3.2.-) (Protein monoglutamylase TTLL4) (Tubulin--tyrosine ligase-like protein 4)
1_MASAG 6_ TQHYS 11_ IGLRQ 16_ KNSFK 21_ QSGPS 26_ GTVPA 31_ TPPEK 36_ PSEGR 41_ VWPQA 46_ HQQVK 51_ PIWKL 56_ EKKQV 61_ ETLSA 66_ GLGPG 71_ LLGVP 76_ PQPAY 81_ FFCPS 86_ TLCSS 91_ GTTAV 96_ IAGHS 101_ SSCYL 106_ HSLPD 111_ LFNST 116_ LLYRR 121_ SSYRQ 126_ KPYQQ 131_ LESFC 136_ LRSSP 141_ SEKSP 146_ FSLPQ 151_ KSLPV 156_ SLTAN 161_ KATSS 166_ MVFSM 171_ AQPMA 176_ SSSTE 181_ PYLCL 186_ AAAGE 191_ NPSGK 196_ SLASA 201_ ISGKI 206_ PSPLS 211_ SSYKP 216_ MLNNN 221_ SFMWP 226_ NSTPV 231_ PLLQT 236_ TQGLK 241_ PVSPP 246_ KIQPV 251_ SWHHS 256_ GGTGD 261_ CAPQP 266_ VDHKV 271_ PKSIG 276_ TVPAD 281_ ASAHI 286_ ALSTA 291_ SSHDT 296_ STTSV 301_ ASSWY 306_ NRNNL 311_ AMRAE 316_ PLSCA 321_ LDDSS 326_ DSQDP 331_ TKEIR 336_ FTEAV 341_ RKLTA 346_ RGFEK 351_ MPRQG 356_ CQLEQ 361_ SSFLN 366_ PSFQW 371_ NVLNR 376_ SRRWK 381_ PPAVN 386_ QQFPQ 391_ EDAGS 396_ VRRVL 401_ PGASD 406_ TLGLD 411_ NTVFC 416_ TKRIS 421_ IHLLA 426_ SHASG 431_ LNHNP 436_ ACESV 441_ IDSSA 446_ FGEGK 451_ APGPP 456_ FPQTL 461_ GIANV 466_ ATRLS 471_ SIQLG 476_ QSEKE 481_ RPEEA 486_ RELDS 491_ SDRDI 496_ SSATD 501_ LQPDQ 506_ AETED 511_ TEEEL 516_ VDGLE 521_ DCCSR 526_ DENEE 531_ EEGDS 536_ ECSSL 541_ SAVSP 546_ SESVA 551_ MISRS 556_ CMEIL 561_ TKPLS 566_ NHEKV 571_ VRPAL 576_ IYSLF 581_ PNVPP 586_ TIYFG 591_ TRDER 596_ VEKLP 601_ WEQRK 606_ LLRWK 611_ MSTVT 616_ PNIVK 621_ QTIGR 626_ SHFKI 631_ SKRND 636_ DWLGC 641_ WGHHM 646_ KSPSF 651_ RSIRE 656_ HQKLN 661_ HFPGS 666_ FQIGR 671_ KDRLW 676_ RNLSR 681_ MQSRF 686_ GKKEF 691_ SFFPQ 696_ SFILP 701_ QDAKL 706_ LRKAW 711_ ESSSR 716_ QKWIV 721_ KPPAS 726_ ARGIG 731_ IQVIH 736_ KWSQL 741_ PKRRP 746_ LLVQR 751_ YLHKP 756_ YLISG 761_ SKFDL 766_ RIYVY 771_ VTSYD 776_ PLRIY 781_ LFSDG 786_ LVRFA 791_ SCKYS 796_ PSMKS 801_ LGNKF 806_ MHLTN 811_ YSVNK 816_ KNAEY 821_ QANAD 826_ EMACQ 831_ GHKWA 836_ LKALW 841_ NYLSQ 846_ KGVNS 851_ DAIWE 856_ KIKDV 861_ VVKTI 866_ ISSEP 871_ YVTSL 876_ LKMYV 881_ RRPYS 886_ CHELF 891_ GFDIM 896_ LDENL 901_ KPWVL 906_ EVNIS 911_ PSLHS 916_ SSPLD 921_ ISIKG 926_ QMIRD 931_ LLNLA 936_ GFVLP 941_ NAEDI 946_ ISSPS 951_ SCSSS 956_ TTSLP 961_ TSPGD 966_ KCRMA 971_ PEHVT 976_ AQKMK 981_ KAYYL 986_ TQKIP 991_ DQDFY 996_ ASVLD 1001_ VLTPD 1006_ DVRIL 1011_ VEMED 1016_ EFSRR 1021_ GQFER 1026_ IFPSH 1031_ ISSRY 1036_ LRFFE 1041_ QPRYF 1046_ NILTT 1051_ QWEQK 1056_ YHGNK 1061_ LKGVD 1066_ LLRSW 1071_ CYKGF 1076_ HMGVV 1081_ SDSAP 1086_ VWSLP 1091_ TSLLT 1096_ ISKDD 1101_ VILNA 1106_ FSKSE 1111_ TSKLG 1116_ KQSSC 1121_ EVSLL 1126_ LSEDG 1131_ TTPKS 1136_ KKTQA 1141_ GLSPY 1146_ PQKPS 1151_ SSKDS 1156_ EDTSK 1161_ EPSLS 1166_ TQTLP 1171_ VIKCS 1176_ GQTSR 1181_ LSASS 1186_ TFQSI 1191_SDSLL
1: Monoglutamylase which modifies both tubulin and non-tubulin proteins, adding a single glutamate on the gamma-carboxyl group of specific glutamate residues of target proteins. Involved in the side-chain initiation step of the polyglutamylation reaction but not in the elongation step. Preferentially modifies beta-tail tubulin over the alpha-tubulin. Monoglutamylates nucleosome assembly proteins NAP1L1 and NAP1L4. Monoglutamylates nucleotidyltransferase CGAS, leading to inhibition of CGAS catalytic activity, thereby preventing antiviral defense function. Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis