Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2)
1_MKDYD 6_ ELLKY 11_ YELHE 16_ TIGTG 21_ GFAKV 26_ KLACH 31_ ILTGE 36_ MVAIK 41_ IMDKN 46_ TLGSD 51_ LPRIK 56_ TEIEA 61_ LKNLR 66_ HQHIC 71_ QLYHV 76_ LETAN 81_ KIFMV 86_ LEYCP 91_ GGELF 96_ DYIIS 101_ QDRLS 106_ EEETR 111_ VVFRQ 116_ IVSAV 121_ AYVHS 126_ QGYAH 131_ RDLKP 136_ ENLLF 141_ DEYHK 146_ LKLID 151_ FGLCA 156_ KPKGN 161_ KDYHL 166_ QTCCG 171_ SLAYA 176_ APELI 181_ QGKSY 186_ LGSEA 191_ DVWSM 196_ GILLY 201_ VLMCG 206_ FLPFD 211_ DDNVM 216_ ALYKK 221_ IMRGK 226_ YDVPK 231_ WLSPS 236_ SILLL 241_ QQMLQ 246_ VDPKK 251_ RISMK 256_ NLLNH 261_ PWIMQ 266_ DYNYP 271_ VEWQS 276_ KNPFI 281_ HLDDD 286_ CVTEL 291_ SVHHR 296_ NNRQT 301_ MEDLI 306_ SLWQY 311_ DHLTA 316_ TYLLL 321_ LAKKA 326_ RGKPV 331_ RLRLS 336_ SFSCG 341_ QASAT 346_ PFTDI 351_ KSNNW 356_ SLEDV 361_ TASDK 366_ NYVAG 371_ LIDYD 376_ WCEDD 381_ LSTGA 386_ ATPRT 391_ SQFTK 396_ YWTES 401_ NGVES 406_ KSLTP 411_ ALCRT 416_ PANKL 421_ KNKEN 426_ VYTPK 431_ SAVKN 436_ EEYFM 441_ FPEPK 446_ TPVNK 451_ NQHKR 456_ EILTT 461_ PNRYT 466_ TPSKA 471_ RNQCL 476_ KETPI 481_ KIPVN 486_ STGTD 491_ KLMTG 496_ VISPE 501_ RRCRS 506_ VELDL 511_ NQAHM 516_ EETPK 521_ RKGAK 526_ VFGSL 531_ ERGLD 536_ KVITV 541_ LTRSK 546_ RKGSA 551_ RDGPR 556_ RLKLH 561_ YNVTT 566_ TRLVN 571_ PDQLL 576_ NEIMS 581_ ILPKK 586_ HVDFV 591_ QKGYT 596_ LKCQT 601_ QSDFG 606_ KVTMQ 611_ FELEV 616_ CQLQK 621_ PDVVG 626_ IRRQR 631_ LKGDA 636_ WVYKR 641_ LVEDI 646_LSSCK
1: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis