Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8)
1_MGFLK 6_ LIEIE 11_ NFKSY 16_ KGRQI 21_ IGPFQ 26_ RFTAI 31_ IGPNG 36_ SGKSN 41_ LMDAI 46_ SFVLG 51_ EKTSN 56_ LRVKT 61_ LRDLI 66_ HGAPV 71_ GKPAA 76_ NRAFV 81_ SMVYS 86_ EEGAE 91_ DRTFA 96_ RVIVG 101_ GSSEY 106_ KINNK 111_ VVQLH 116_ EYSEE 121_ LEKLG 126_ ILIKA 131_ RNFLV 136_ FQGAV 141_ ESIAM 146_ KNPKE 151_ RTALF 156_ EEISR 161_ SGELA 166_ QEYDK 171_ RKKEM 176_ VKAEE 181_ DTQFN 186_ YHRKK 191_ NIAAE 196_ RKEAK 201_ QEKEE 206_ ADRYQ 211_ RLKDE 216_ VVRAQ 221_ VQLQL 226_ FKLYH 231_ NEVEI 236_ EKLNK 241_ ELASK 246_ NKEIE 251_ KDKKR 256_ MDKVE 261_ DELKE 266_ KKKEL 271_ GKMMR 276_ EQQQI 281_ EKEIK 286_ EKDSE 291_ LNQKR 296_ PQYIK 301_ AKENT 306_ SHKIK 311_ KLEAA 316_ KKSLQ 321_ NAQKH 326_ YKKRK 331_ GDMDE 336_ LEKEM 341_ LSVEK 346_ ARQEF 351_ EERME 356_ EESQS 361_ QGRDL 366_ TLEEN 371_ QVKKY 376_ HRLKE 381_ EASKR 386_ AATLA 391_ QELEK 396_ FNRDQ 401_ KADQD 406_ RLDLE 411_ ERKKV 416_ ETEAK 421_ IKQKL 426_ REIEE 431_ NQKRI 436_ EKLEE 441_ YITTS 446_ KQSLE 451_ EQKKL 456_ EGELT 461_ EEVEM 466_ AKRRI 471_ DEINK 476_ ELNQV 481_ MEQLG 486_ DARID 491_ RQESS 496_ RQQRK 501_ AEIME 506_ SIKRL 511_ YPGSV 516_ YGRLI 521_ DLCQP 526_ TQKKY 531_ QIAVT 536_ KVLGK 541_ NMDAI 546_ IVDSE 551_ KTGRD 556_ CIQYI 561_ KEQRG 566_ EPETF 571_ LPLDY 576_ LEVKP 581_ TDEKL 586_ RELKG 591_ AKLVI 596_ DVIRY 601_ EPPHI 606_ KKALQ 611_ YACGN 616_ ALVCD 621_ NVEDA 626_ RRIAF 631_ GGHQR 636_ HKTVA 641_ LDGTL 646_ FQKSG 651_ VISGG 656_ ASDLK 661_ AKARR 666_ WDEKA 671_ VDKLK 676_ EKKER 681_ LTEEL 686_ KEQMK 691_ AKRKE 696_ AELRQ 701_ VQSQA 706_ HGLQM 711_ RLKYS 716_ QSDLE 721_ QTKTR 726_ HLALN 731_ LQEKS 736_ KLESE 741_ LANFG 746_ PRIND 751_ IKRII 756_ QSRER 761_ EMKDL 766_ KEKMN 771_ QVEDE 776_ VFEEF 781_ CREIG 786_ VRNIR 791_ EFEEE 796_ KVKRQ 801_ NEIAK 806_ KRLEF 811_ ENQKT 816_ RLGIQ 821_ LDFEK 826_ NQLKE 831_ DQDKV 836_ HMWEQ 841_ TVKKD 846_ ENEIE 851_ KLKKE 856_ EQRHM 861_ KIIDE 866_ TMAQL 871_ QDLKN 876_ QHLAK 881_ KSEVN 886_ DKNHE 891_ MEEIR 896_ KKLGG 901_ ANKEM 906_ THLQK 911_ EVTAI 916_ ETKLE 921_ QKRSD 926_ RHNLL 931_ QACKM 936_ QDIKL 941_ PLSKG 946_ TMDDI 951_ SQEEG 956_ SSQGE 961_ DSVSG 966_ SQRIS 971_ SIYAR 976_ EALIE 981_ IDYGD 986_ LCEDL 991_ KDAQA 996_ EEEIK 1001_ QEMNT 1006_ LQQKL 1011_ NEQQS 1016_ VLQRI 1021_ AAPNM 1026_ KAMEK 1031_ LESVR 1036_ DKFQE 1041_ TSDEF 1046_ EAARK 1051_ RAKKA 1056_ KQAFE 1061_ QIKKE 1066_ RFDRF 1071_ NACFE 1076_ SVATN 1081_ IDEIY 1086_ KALSR 1091_ NSSAQ 1096_ AFLGP 1101_ ENPEE 1106_ PYLDG 1111_ INYNC 1116_ VAPGK 1121_ RFRPM 1126_ DNLSG 1131_ GEKTV 1136_ AALAL 1141_ LFAIH 1146_ SYKPA 1151_ PFFVL 1156_ DEIDA 1161_ ALDNT 1166_ NIGKV 1171_ ANYIK 1176_ EQSTC 1181_ NFQAI 1186_ VISLK 1191_ EEFYT 1196_ KAESL 1201_ IGVYP 1206_ EQGDC 1211_ VISKV 1216_ LTFDL 1221_ TKYPD 1226_ANPNP
1: Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint