DNA replication complex GINS protein PSF1 (GINS complex subunit 1)
1_MFCEK 6_ AMELI 11_ RELHR 16_ APEGQ 21_ LPAFN 26_ EDGLR 31_ QVLEE 36_ MKALY 41_ EQNQS 46_ DVNEA 51_ KSGGR 56_ SDLIP 61_ TIKFR 66_ HCSLL 71_ RNRRC 76_ TVAYL 81_ YDRLL 86_ RIRAL 91_ RWEYG 96_ SVLPN 101_ ALRFH 106_ MAAEE 111_ MEWFN 116_ NYKRS 121_ LATYM 126_ RSLGG 131_ DEGLD 136_ ITQDM 141_ KPPKS 146_ LYIEV 151_ RCLKD 156_ YGEFE 161_ VDDGT 166_ SVLLK 171_ KNSQH 176_ FLPRW 181_ KCEQL 186_ IRQGV 191_LEHIL
1: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653, PubMed:28414293). GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232)