Phosphatidate phosphatase LPIN1 (EC 3.1.3.4) (Lipin-1)
1_MNYVG 6_ QLAGQ 11_ VFVTV 16_ KELYK 21_ GLNPA 26_ TLSGC 31_ IDIIV 36_ IRQPN 41_ GNLQC 46_ SPFHV 51_ RFGKM 56_ GVLRS 61_ REKVV 66_ DIEIN 71_ GESVD 76_ LHMKL 81_ GDNGE 86_ AFFVQ 91_ ETDND 96_ QEVIP 101_ MHLAT 106_ SPILS 111_ EGASR 116_ MECQL 121_ KRGSV 126_ DRMRG 131_ LDPST 136_ PAQVI 141_ APSET 146_ PSSSS 151_ VVKKR 156_ RKRRR 161_ KSQLD 166_ SLKRD 171_ DNMNT 176_ SEDED 181_ MFPIE 186_ MSSDE 191_ AMELL 196_ ESSRT 201_ LPNDI 206_ PPFQD 211_ DIPEE 216_ NLSLA 221_ VIYPQ 226_ SASYP 231_ NSDRE 236_ WSPTP 241_ SPSGS 246_ RPSTP 251_ KSDSE 256_ LVSKS 261_ TERTG 266_ QKNPE 271_ MLWLW 276_ GELPQ 281_ AAKSS 286_ SPHKM 291_ KESSP 296_ LSSRK 301_ ICDKS 306_ HFQAI 311_ HSESS 316_ DTFSD 321_ QSPTL 326_ VGGAL 331_ LDQNK 336_ PQTEM 341_ QFVNE 346_ EDLET 351_ LGAAA 356_ PLLPM 361_ IEELK 366_ PPSAS 371_ VVQTA 376_ NKTDS 381_ PSRKR 386_ DKRSR 391_ HLGAD 396_ GVYLD 401_ DLTDM 406_ DPEVA 411_ ALYFP 416_ KNGDP 421_ SGLAK 426_ HASDN 431_ GARSA 436_ NQSPQ 441_ SVGSS 446_ GVDSG 451_ VESTS 456_ DGLRD 461_ LPSIA 466_ ISLCG 471_ GLSDH 476_ REITK 481_ DAFLE 486_ QAVSY 491_ QQFVD 496_ NPAII 501_ DDPNL 506_ VVKIG 511_ SKYYN 516_ WTTAA 521_ PLLLA 526_ MQAFQ 531_ KPLPK 536_ ATVES 541_ IMRDK 546_ MPKKG 551_ GRWWF 556_ SWRGR 561_ NTTIK 566_ EESKP 571_ EQCLA 576_ GKAHS 581_ TGEQP 586_ PQLSL 591_ ATRVK 596_ HESSS 601_ SDEER 606_ AAAKP 611_ SNAGH 616_ LPLLP 621_ NVSYK 626_ KTLRL 631_ TSEQL 636_ KSLKL 641_ KNGPN 646_ DVVFS 651_ VTTQY 656_ QGTCR 661_ CEGTI 666_ YLWNW 671_ DDKVI 676_ ISDID 681_ GTITR 686_ SDTLG 691_ HILPT 696_ LGKDW 701_ THQGI 706_ AKLYH 711_ KVSQN 716_ GYKFL 721_ YCSAR 726_ AIGMA 731_ DMTRG 736_ YLHWV 741_ NERGT 746_ VLPQG 751_ PLLLS 756_ PSSLF 761_ SALHR 766_ EVIEK 771_ KPEKF 776_ KVQCL 781_ TDIKN 786_ LFFPN 791_ TEPFY 796_ AAFGN 801_ RPADV 806_ YSYKQ 811_ VGVSL 816_ NRIFT 821_ VNPKG 826_ ELVQE 831_ HAKTN 836_ ISSYV 841_ RLCEV 846_ VDHVF 851_ PLLKR 856_ SHSSD 861_ FPCSD 866_ TFSNF 871_ TFWRE 876_ PLPPF 881_ENQDI
1: Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis and therefore controls the metabolism of fatty acids at different levels (PubMed:20231281, PubMed:23426360, PubMed:29765047, PubMed:31695197). Is involved in adipocyte differentiation (By similarity). Recruited at the mitochondrion outer membrane and is involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol (By similarity). Acts also as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression (By similarity)