LRP chaperone MESD (LDLR chaperone MESD) (Mesoderm development LRP chaperone MESD) (Mesoderm development candidate 2) (Mesoderm development protein) (Renal carcinoma antigen NY-REN-61)
1_MAASR 6_ WARKA 11_ VVLLC 16_ ASDLL 21_ LLLLL 26_ LPPPG 31_ SCAAE 36_ GSPGT 41_ PDEST 46_ PPPRK 51_ KKKDI 56_ RDYND 61_ ADMAR 66_ LLEQW 71_ EKDDD 76_ IEEGD 81_ LPEHK 86_ RPSAP 91_ VDFSK 96_ IDPSK 101_ PESIL 106_ KMTKK 111_ GKTLM 116_ MFVTV 121_ SGSPT 126_ EKETE 131_ EITSL 136_ WQGSL 141_ FNANY 146_ DVQRF 151_ IVGSD 156_ RAIFM 161_ LRDGS 166_ YAWEI 171_ KDFLV 176_ GQDRC 181_ ADVTL 186_ EGQVY 191_ PGKGG 196_ GSKEK 201_ NKTKQ 206_ DKGKK 211_ KKEGD 216_ LKSRS 221_ SKEEN 226_RAGNK
1: Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs) (PubMed:15014448). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane (PubMed:17488095, PubMed:23572575). Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4 (By similarity). May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells (By similarity)