Raftlin (Cell migration-inducing gene 2 protein) (Raft-linking protein)
1_MGCGL 6_ NKLEK 11_ RDEKR 16_ PGNIY 21_ STLKR 26_ PQVET 31_ KIDVS 36_ YEYRF 41_ LEFTT 46_ LSAAE 51_ LPGSS 56_ AVRLA 61_ SLRDL 66_ PAQLL 71_ ELYQQ 76_ GFSLA 81_ ALHPF 86_ VQPTH 91_ EREKT 96_ PLEHI 101_ FRAIL 106_ IKKTD 111_ RSQKT 116_ DLHNE 121_ GYILE 126_ LDCCS 131_ SLDHP 136_ TDQKL 141_ IPEFI 146_ KKIQE 151_ AASQG 156_ LKFVG 161_ VIPQY 166_ HSSVN 171_ SAGSS 176_ APVST 181_ ANSTE 186_ DARDA 191_ KNARG 196_ DHASL 201_ ENEKP 206_ GTGDV 211_ CSAPA 216_ GRNQS 221_ PEPSS 226_ GPRGE 231_ VPLAK 236_ QPSSP 241_ SGEGD 246_ GGELS 251_ PQGVS 256_ KTLDG 261_ PESNP 266_ LEVHE 271_ EPLSG 276_ KMEIF 281_ TLFNK 286_ PKSHQ 291_ KCRQY 296_ YPVTI 301_ PLHVS 306_ KNGQT 311_ VSGLD 316_ ANWLE 321_ HMSDH 326_ FRKGG 331_ MLVNA 336_ VFYLG 341_ IVNDS 346_ LHGLT 351_ DGVFI 356_ FEAVS 361_ TEDSK 366_ TIQGY 371_ DAIVV 376_ EQWTV 381_ LEGVE 386_ VQTDY 391_ VPLLN 396_ SLAAY 401_ GWQLT 406_ CVLPT 411_ PVVKT 416_ TSEGS 421_ VSTKQ 426_ IVFLQ 431_ RPCLP 436_ QKIKK 441_ KESKF 446_ QWRFS 451_ REEMH 456_ NRQMR 461_ KSKGK 466_ LSARD 471_ KQQAE 476_ ENEKN 481_ LEDQS 486_ SKAGD 491_ MGNCV 496_ SGQQQ 501_ EGGVS 506_ EEMKG 511_ PVQED 516_ KGEQL 521_ SPGGL 526_ LCGVG 531_ VEGEA 536_ VQNGP 541_ ASHSR 546_ ALVGI 551_ CTGHS 556_ NPGED 561_ ARDGD 566_ AEEVR 571_ELGTV
1: Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:21266579, PubMed:27022195). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:21266579, PubMed:27022195). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216)