Voltage-gated potassium channel subunit beta-1 (EC 1.1.1.-) (K(+) channel subunit beta-1) (Kv-beta-1)
1_MLAAR 6_ TGAAG 11_ SQISE 16_ ENTKL 21_ RRQSG 26_ FSVAG 31_ KDKSP 36_ KKASE 41_ NAKDS 46_ SLSPS 51_ GESQL 56_ RARQL 61_ ALLRE 66_ VEMNW 71_ YLKLC 76_ DLSSE 81_ HTTVC 86_ TTGMP 91_ HRNLG 96_ KSGLR 101_ VSCLG 106_ LGTWV 111_ TFGGQ 116_ ISDEV 121_ AERLM 126_ TIAYE 131_ SGVNL 136_ FDTAE 141_ VYAAG 146_ KAEVI 151_ LGSII 156_ KKKGW 161_ RRSSL 166_ VITTK 171_ LYWGG 176_ KAETE 181_ RGLSR 186_ KHIIE 191_ GLKGS 196_ LQRLQ 201_ LEYVD 206_ VVFAN 211_ RPDSN 216_ TPMEE 221_ IVRAM 226_ THVIN 231_ QGMAM 236_ YWGTS 241_ RWSAM 246_ EIMEA 251_ YSVAR 256_ QFNMI 261_ PPVCE 266_ QAEYH 271_ LFQRE 276_ KVEVQ 281_ LPELY 286_ HKIGV 291_ GAMTW 296_ SPLAC 301_ GIISG 306_ KYGNG 311_ VPESS 316_ RASLK 321_ CYQWL 326_ KERIV 331_ SEEGR 336_ KQQNK 341_ LKDLS 346_ PIAER 351_ LGCTL 356_ PQLAV 361_ AWCLR 366_ NEGVS 371_ SVLLG 376_ SSTPE 381_ QLIEN 386_ LGAIQ 391_ VLPKM 396_ TSHVV 401_ NEIDN 406_ ILRNK 411_PYSKK
1: Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (PubMed:17156368, PubMed:17540341, PubMed:19713757, PubMed:7499366, PubMed:7603988). The beta-1/KCNAB1 cytoplasmic subunit mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623). Promotes the inactivation of Kv1.1/KCNA1, Kv1.2/KCNA2, Kv1.4/KCNA4, Kv1.5/KCNA5 and Kv1.6/KCNA6 alpha subunit-containing channels (PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17156368, PubMed:17540341, PubMed:19713757, PubMed:7499366, PubMed:7603988, PubMed:7649300, PubMed:7890764, PubMed:9763623). Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a variety of endogenous aldehydes and ketones (By similarity). The binding of NADPH is required for efficient down-regulation of potassium channel activity (PubMed:17540341). Oxidation of the bound NADPH restrains N-terminal domain from blocking the channel, thereby decreasing N-type inactivation of potassium channel activity (By similarity)
2: Isoform KvB1.2 shows no effect on KCNA1, KCNA2 or KCNB1