Delta(14)-sterol reductase LBR (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (C14SR) (Integral nuclear envelope inner membrane protein) (LMN2R) (Lamin-B receptor) (Sterol C14-reductase)
1_MPSRK 6_ FADGE 11_ VVRGR 16_ WPGSS 21_ LYYEV 26_ EILSH 31_ DSTSQ 36_ LYTVK 41_ YKDGT 46_ ELELK 51_ ENDIK 56_ PLTSF 61_ RQRKG 66_ GSTSS 71_ SPSRR 76_ RGSRS 81_ RSRSR 86_ SPGRP 91_ PKSAR 96_ RSASA 101_ SHQAD 106_ IKEAR 111_ REVEV 116_ KLTPL 121_ ILKPF 126_ GNSIS 131_ RYNGE 136_ PEHIE 141_ RNDAP 146_ HKNTQ 151_ EKFSL 156_ SQESS 161_ YIATQ 166_ YSLRP 171_ RREEV 176_ KLKEI 181_ DSKEE 186_ KYVAK 191_ ELAVR 196_ TFEVT 201_ PIRAK 206_ DLEFG 211_ GVPGV 216_ FLIMF 221_ GLPVF 226_ LFLLL 231_ LMCKQ 236_ KDPSL 241_ LNFPP 246_ PLPAL 251_ YELWE 256_ TRVFG 261_ VYLLW 266_ FLIQV 271_ LFYLL 276_ PIGKV 281_ VEGTP 286_ LIDGR 291_ RLKYR 296_ LNGFY 301_ AFILT 306_ SAVIG 311_ TSLFQ 316_ GVEFH 321_ YVYSH 326_ FLQFA 331_ LAATV 336_ FCVVL 341_ SVYLY 346_ MRSLK 351_ APRND 356_ LSPAS 361_ SGNAV 366_ YDFFI 371_ GRELN 376_ PRIGT 381_ FDLKY 386_ FCELR 391_ PGLIG 396_ WVVIN 401_ LVMLL 406_ AEMKI 411_ QDRAV 416_ PSLAM 421_ ILVNS 426_ FQLLY 431_ VVDAL 436_ WNEEA 441_ LLTTM 446_ DIIHD 451_ GFGFM 456_ LAFGD 461_ LVWVP 466_ FIYSF 471_ QAFYL 476_ VSHPN 481_ EVSWP 486_ MASLI 491_ IVLKL 496_ CGYVI 501_ FRGAN 506_ SQKNA 511_ FRKNP 516_ SDPKL 521_ AHLKT 526_ IHTST 531_ GKNLL 536_ VSGWW 541_ GFVRH 546_ PNYLG 551_ DLIMA 556_ LAWSL 561_ PCGFN 566_ HILPY 571_ FYIIY 576_ FTMLL 581_ VHREA 586_ RDEYH 591_ CKKKY 596_ GVAWE 601_ KYCQR 606_VPYRI
1: Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722, PubMed:9630650). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (PubMed:10828963)