Chromobox protein homolog 2
1_MEELS 6_ SVGEQ 11_ VFAAE 16_ CILSK 21_ RLRKG 26_ KLEYL 31_ VKWRG 36_ WSSKH 41_ NSWEP 46_ EENIL 51_ DPRLL 56_ LAFQK 61_ KEHEK 66_ EVQNR 71_ KRGKR 76_ PRGRP 81_ RKLTA 86_ MSSCS 91_ RRSKL 96_ KEPDA 101_ PSKSK 106_ SSSSS 111_ SSSTS 116_ SSSSS 121_ DEEDD 126_ SDLDA 131_ KRGPR 136_ GRETH 141_ PVPQK 146_ KAQIL 151_ VAKPE 156_ LKDPI 161_ RKKRG 166_ RKPLP 171_ PEQKA 176_ TRRPV 181_ SLAKV 186_ LKTAR 191_ KDLGA 196_ PASKL 201_ PPPLS 206_ APVAG 211_ LAALK 216_ AHAKE 221_ ACGGP 226_ SAMAT 231_ PENLA 236_ SLMKG 241_ MASSP 246_ GRGGI 251_ SWQSS 256_ IVHYM 261_ NRMTQ 266_ SQAQA 271_ ASRLA 276_ LKAQA 281_ TNKCG 286_ LGLDL 291_ KVRTQ 296_ KGELG 301_ MSPPG 306_ SKIPK 311_ APSGG 316_ AVEQK 321_ VGNTG 326_ GPPHT 331_ HGASR 336_ VPAGC 341_ PGPQP 346_ APTQE 351_ LSLQV 356_ LDLQS 361_ VKNGM 366_ PGVGL 371_ LARHA 376_ TATKG 381_ VPATN 386_ PAPGK 391_ GTGSG 396_ LIGAS 401_ GATMP 406_ TDTSK 411_ SEKLA 416_ SRAVA 421_ PPTPA 426_ SKRDC 431_ VKGSA 436_ TPSGQ 441_ ESRTA 446_ PGEAR 451_ KAATL 456_ PEMSA 461_ GEESS 466_ SSDSD 471_ PDSAS 476_ PPSTG 481_ QNPSV 486_ SVQTS 491_ QDWKP 496_ TRSLI 501_ EHVFV 506_ TDVTA 511_ NLITV 516_ TVKES 521_ PTSVG 526_FFNLR
1: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). Involved in sexual development, acting as activator of NR5A1 expression (PubMed:19361780)