StAR-related lipid transfer protein 3 (Metastatic lymph node gene 64 protein) (MLN 64) (Protein CAB1) (START domain-containing protein 3) (StARD3)
1_MSKLP 6_ RELTR 11_ DLERS 16_ LPAVA 21_ SLGSS 26_ LSHSQ 31_ SLSSH 36_ LLPPP 41_ EKRRA 46_ ISDVR 51_ RTFCL 56_ FVTFD 61_ LLFIS 66_ LLWII 71_ ELNTN 76_ TGIRK 81_ NLEQE 86_ IIQYN 91_ FKTSF 96_ FDIFV 101_ LAFFR 106_ FSGLL 111_ LGYAV 116_ LRLRH 121_ WWVIA 126_ VTTLV 131_ SSAFL 136_ IVKVI 141_ LSELL 146_ SKGAF 151_ GYLLP 156_ IVSFV 161_ LAWLE 166_ TWFLD 171_ FKVLP 176_ QEAEE 181_ ERWYL 186_ AAQVA 191_ VARGP 196_ LLFSG 201_ ALSEG 206_ QFYSP 211_ PESFA 216_ GSDNE 221_ SDEEV 226_ AGKKS 231_ FSAQE 236_ REYIR 241_ QGKEA 246_ TAVVD 251_ QILAQ 256_ EENWK 261_ FEKNN 266_ EYGDT 271_ VYTIE 276_ VPFHG 281_ KTFIL 286_ KTFLP 291_ CPAEL 296_ VYQEV 301_ ILQPE 306_ RMVLW 311_ NKTVT 316_ ACQIL 321_ QRVED 326_ NTLIS 331_ YDVSA 336_ GAAGG 341_ VVSPR 346_ DFVNV 351_ RRIER 356_ RRDRY 361_ LSSGI 366_ ATSHS 371_ AKPPT 376_ HKYVR 381_ GENGP 386_ GGFIV 391_ LKSAS 396_ NPRVC 401_ TFVWI 406_ LNTDL 411_ KGRLP 416_ RYLIH 421_ QSLAA 426_ TMFEF 431_ AFHLR 436_QRISE
1: Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:11053434, PubMed:15930133, PubMed:22514632, PubMed:28377464, PubMed:33124732). The sterol transport mechanism is triggered by phosphorylation of FFAT motif that leads to membrane tethering between the endoplasmic reticulum and late endosomes via interaction with VAPA and VAPB (PubMed:24105263, PubMed:28377464, PubMed:33124732). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (PubMed:28377464). May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane (PubMed:12070139, PubMed:19965586). However, such results need additional experimental evidences; probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:28377464). Does not activate transcriptional cholesterol sensing (PubMed:28377464). Able to bind other lipids, such as lutein, a xanthophyll carotenoids that form the macular pigment of the retina (PubMed:21322544)