Prostaglandin reductase 1 (PRG-1) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48) (Dithiolethione-inducible gene 1 protein) (D3T-inducible gene 1 protein) (DIG-1) (Leukotriene B4 12-hydroxydehydrogenase) (NAD(P)H-dependent alkenal/one oxidoreductase) (EC 1.3.1.74)
1_MVRTK 6_ TWTLK 11_ KHFVG 16_ YPTNS 21_ DFELK 26_ TAELP 31_ PLKNG 36_ EVLLE 41_ ALFLT 46_ VDPYM 51_ RVAAK 56_ RLKEG 61_ DTMMG 66_ QQVAK 71_ VVESK 76_ NVALP 81_ KGTIV 86_ LASPG 91_ WTTHS 96_ ISDGK 101_ DLEKL 106_ LTEWP 111_ DTIPL 116_ SLALG 121_ TVGMP 126_ GLTAY 131_ FGLLE 136_ ICGVK 141_ GGETV 146_ MVNAA 151_ AGAVG 156_ SVVGQ 161_ IAKLK 166_ GCKVV 171_ GAVGS 176_ DEKVA 181_ YLQKL 186_ GFDVV 191_ FNYKT 196_ VESLE 201_ ETLKK 206_ ASPDG 211_ YDCYF 216_ DNVGG 221_ EFSNT 226_ VIGQM 231_ KKFGR 236_ IAICG 241_ AISTY 246_ NRTGP 251_ LPPGP 256_ PPEIV 261_ IYQEL 266_ RMEAF 271_ VVYRW 276_ QGDAR 281_ QKALK 286_ DLLKW 291_ VLEGK 296_ IQYKE 301_ YIIEG 306_ FENMP 311_ AAFMG 316_ MLKGD 321_NLGKT
1: NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX) (PubMed:25619643). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha (PubMed:25619643). Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (By similarity) (PubMed:25619643). Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site (By similarity). May play a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (PubMed:25619643). May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (By similarity)