Dr1-associated corepressor (Dr1-associated protein 1) (Negative cofactor 2-alpha) (NC2-alpha)
1_MPSKK 6_ KKYNA 11_ RFPPA 16_ RIKKI 21_ MQTDE 26_ EIGKV 31_ AAAVP 36_ VIISR 41_ ALELF 46_ LESLL 51_ KKACQ 56_ VTQSR 61_ NAKTM 66_ TTSHL 71_ KQCIE 76_ LEQQF 81_ DFLKD 86_ LVASV 91_ PDMQG 96_ DGEDN 101_ HMDGD 106_ KGARR 111_ GRKPG 116_ SGGRK 121_ NGGMG 126_ TKSKD 131_ KKLSG 136_ TDSEQ 141_ EDESE 146_ DTDTD 151_ GEEET 156_ SQPPP 161_ QASHP 166_ SAHFQ 171_ SPPTP 176_ FLPFA 181_ STLPL 186_ PPAPP 191_ GPSAP 196_DEEDE
1: The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own