Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3)
1_MGAAS 6_ CEDEE 11_ LEFKL 16_ VFGEE 21_ KEAPP 26_ LGAGG 31_ LGEEL 36_ DSEDA 41_ PPCCR 46_ LALGE 51_ PPPYG 56_ AAPIG 61_ IPRPP 66_ PPRPG 71_ MHSPP 76_ PRPAP 81_ SPGTW 86_ ESQPA 91_ RSVRL 96_ GGPGG 101_ GAGGA 106_ GGGRV 111_ LECPS 116_ IRITS 121_ ISPTP 126_ EPPAA 131_ LEDNP 136_ DAWGD 141_ GSPRD 146_ YPPPE 151_ GFGGY 156_ REAGG 161_ QGGGA 166_ FFSPS 171_ PGSSS 176_ LSSWS 181_ FFSDA 186_ SDEAA 191_ LYAAC 196_ DEVES 201_ ELNEA 206_ ASRFG 211_ LGSPL 216_ PSPRA 221_ SPRPW 226_ TPEDP 231_ WSLYG 236_ PSPGG 241_ RGPED 246_ SWLLL 251_ SAPGP 256_ TPASP 261_ RPASP 266_ CGKRR 271_ YSSSG 276_ TPSSA 281_ SPALS 286_ RRGSL 291_ GEEGS 296_ EPPPP 301_ PPLPL 306_ ARDPG 311_ SPGPF 316_ DYVGA 321_ PPAES 326_ IPQKT 331_ RRTSS 336_ EQAVA 341_ LPRSE 346_ EPASC 351_ NGKLP 356_ LGAEE 361_ SVAPP 366_ GGSRK 371_ EVAGM 376_ DYLAV 381_ PSPLA 386_ WSKAR 391_ IGGHS 396_ PIFRT 401_ SALPP 406_ LDWPL 411_ PSQYE 416_ QLELR 421_ IEVQP 426_ RAHHR 431_ AHYET 436_ EGSRG 441_ AVKAA 446_ PGGHP 451_ VVKLL 456_ GYSEK 461_ PLTLQ 466_ MFIGT 471_ ADERN 476_ LRPHA 481_ FYQVH 486_ RITGK 491_ MVATA 496_ SYEAV 501_ VSGTK 506_ VLEMT 511_ LLPEN 516_ NMAAN 521_ IDCAG 526_ ILKLR 531_ NSDIE 536_ LRKGE 541_ TDIGR 546_ KNTRV 551_ RLVFR 556_ VHVPQ 561_ GGGKV 566_ VSVQA 571_ ASVPI 576_ ECSQR 581_ SAQEL 586_ PQVEA 591_ YSPSA 596_ CSVRG 601_ GEELV 606_ LTGSN 611_ FLPDS 616_ KVVFI 621_ ERGPD 626_ GKLQW 631_ EEEAT 636_ VNRLQ 641_ SNEVT 646_ LTLTV 651_ PEYSN 656_ KRVSR 661_ PVQVY 666_ FYVSN 671_ GRRKR 676_ SPTQS 681_ FRFLP 686_ VICKE 691_ EPLPD 696_ SSLRG 701_ FPSAS 706_ ATPFG 711_ TDMDF 716_ SPPRP 721_ PYPSY 726_ PHEDP 731_ ACETP 736_ YLSEG 741_ FGYGM 746_ PPLYP 751_ QTGPP 756_ PSYRP 761_ GLRMF 766_ PETRG 771_ TTGCA 776_ QPPAV 781_ SFLPR 786_ PFPSD 791_ PYGGR 796_ GSSFS 801_ LGLPF 806_ SPPAP 811_ FRPPP 816_ LPASP 821_ PLEGP 826_ FPSQS 831_ DVHPL 836_ PAEGY 841_ NKVGP 846_ GYGPG 851_ EGAPE 856_ QEKSR 861_ GGYSS 866_ GFRDS 871_ VPIQG 876_ ITLEE 881_ VSEII 886_ GRDLS 891_ GFPAP 896_PGEEP
1: Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:11514544, PubMed:11997522, PubMed:17213202, PubMed:17875713, PubMed:18668201, PubMed:25663301, PubMed:7749981). Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:18347059, PubMed:18668201, PubMed:7749981). Along with NFATC3, involved in embryonic heart development. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) (PubMed:25663301). Plays a role in adipocyte differentiation (PubMed:11997522). May be involved in myoblast differentiation into myotubes (PubMed:17213202). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription (PubMed:11514544). Binds to PPARG gene promoter and regulates its activity (PubMed:11997522). Binds to PPARG and REG3G gene promoters (By similarity)