Killer cell immunoglobulin-like receptor 2DS5 (CD158 antigen-like family member G) (Natural killer-associated transcript 9) (NKAT-9) (CD antigen CD158g)
1_MSLMV 6_ ISMAC 11_ VAFFL 16_ LQGAW 21_ PHEGF 26_ RRKPS 31_ LLAHP 36_ GPLVK 41_ SEETV 46_ ILQCW 51_ SDVMF 56_ EHFLL 61_ HREGT 66_ FNHTL 71_ RLIGE 76_ HIDGV 81_ SKGNF 86_ SIGRM 91_ TQDLA 96_ GTYRC 101_ YGSVT 106_ HSPYQ 111_ LSAPS 116_ DPLDI 121_ VITGL 126_ YEKPS 131_ LSAQP 136_ GPTVL 141_ AGESV 146_ TLSCS 151_ SRSSY 156_ DMYHL 161_ SREGE 166_ AHERR 171_ LPAGP 176_ KVNRT 181_ FQADF 186_ PLDPA 191_ THGGT 196_ YRCFG 201_ SFRDS 206_ PYEWS 211_ KSSDP 216_ LLVSV 221_ TGNSS 226_ NSWPS 231_ PTEPS 236_ SETGN 241_ PRHLH 246_ VLIGT 251_ SVVKL 256_ PFTIL 261_ LFFLL 266_ HRWCS 271_ NKKNA 276_ SVMDQ 281_ GPAGN 286_ RTVNR 291_ EDSDE 296_QDHQE
1: Activating natural killer (NK) receptor that recognizes C2 epitopes of HLA-C alleles. Bridging the innate and adaptive immune systems, NK cells express a number of cell surface receptors which either inhibit or stimulate their cytotoxicity (PubMed:18624290, PubMed:18682925, PubMed:28685972). Able to activate NK cells citotoxicity and cytokine production such as IFNG (PubMed:18624290, PubMed:24269691). Receptor functions are attenuated even lost in some alleles, such as KIR2DS5*002 represented in this entry (PubMed:28685972)