Glutamate receptor ionotropic, NMDA 2C (GluN2C) (Glutamate [NMDA] receptor subunit epsilon-3) (N-methyl D-aspartate receptor subtype 2C) (NMDAR2C) (NR2C)
1_MGGAL 6_ GPALL 11_ LTSLF 16_ GAWAG 21_ LGPGQ 26_ GEQGM 31_ TVAVV 36_ FSSSG 41_ PPQAQ 46_ FRARL 51_ TPQSF 56_ LDLPL 61_ EIQPL 66_ TVGVN 71_ TTNPS 76_ SLLTQ 81_ ICGLL 86_ GAAHV 91_ HGIVF 96_ EDNVD 101_ TEAVA 106_ QILDF 111_ ISSQT 116_ HVPIL 121_ SISGG 126_ SAVVL 131_ TPKEP 136_ GSAFL 141_ QLGVS 146_ LEQQL 151_ QVLFK 156_ VLEEY 161_ DWSAF 166_ AVITS 171_ LHPGH 176_ ALFLE 181_ GVRAV 186_ ADASH 191_ VSWRL 196_ LDVVT 201_ LELGP 206_ GGPRA 211_ RTQRL 216_ LRQLD 221_ APVFV 226_ AYCSR 231_ EEAEV 236_ LFAEA 241_ AQAGL 246_ VGPGH 251_ VWLVP 256_ NLALG 261_ STDAP 266_ PATFP 271_ VGLIS 276_ VVTES 281_ WRLSL 286_ RQKVR 291_ DGVAI 296_ LALGA 301_ HSYWR 306_ QHGTL 311_ PAPAG 316_ DCRVH 321_ PGPVS 326_ PAREA 331_ FYRHL 336_ LNVTW 341_ EGRDF 346_ SFSPG 351_ GYLVQ 356_ PTMVV 361_ IALNR 366_ HRLWE 371_ MVGRW 376_ EHGVL 381_ YMKYP 386_ VWPRY 391_ SASLQ 396_ PVVDS 401_ RHLTV 406_ ATLEE 411_ RPFVI 416_ VESPD 421_ PGTGG 426_ CVPNT 431_ VPCRR 436_ QSNHT 441_ FSSGD 446_ VAPYT 451_ KLCCK 456_ GFCID 461_ ILKKL 466_ ARVVK 471_ FSYDL 476_ YLVTN 481_ GKHGK 486_ RVRGV 491_ WNGMI 496_ GEVYY 501_ KRADM 506_ AIGSL 511_ TINEE 516_ RSEIV 521_ DFSVP 526_ FVETG 531_ ISVMV 536_ ARSNG 541_ TVSPS 546_ AFLEP 551_ YSPAV 556_ WVMMF 561_ VMCLT 566_ VVAIT 571_ VFMFE 576_ YFSPV 581_ SYNQN 586_ LTRGK 591_ KSGGP 596_ AFTIG 601_ KSVWL 606_ LWALV 611_ FNNSV 616_ PIENP 621_ RGTTS 626_ KIMVL 631_ VWAFF 636_ AVIFL 641_ ASYTA 646_ NLAAF 651_ MIQEQ 656_ YIDTV 661_ SGLSD 666_ KKFQR 671_ PQDQY 676_ PPFRF 681_ GTVPN 686_ GSTER 691_ NIRSN 696_ YRDMH 701_ THMVK 706_ FNQRS 711_ VEDAL 716_ TSLKM 721_ GKLDA 726_ FIYDA 731_ AVLNY 736_ MAGKD 741_ EGCKL 746_ VTIGS 751_ GKVFA 756_ TTGYG 761_ IAMQK 766_ DSHWK 771_ RAIDL 776_ ALLQF 781_ LGDGE 786_ TQKLE 791_ TVWLS 796_ GICQN 801_ EKNEV 806_ MSSKL 811_ DIDNM 816_ AGVFY 821_ MLLVA 826_ MGLAL 831_ LVFAW 836_ EHLVY 841_ WKLRH 846_ SVPNS 851_ SQLDF 856_ LLAFS 861_ RGIYS 866_ CFSGV 871_ QSLAS 876_ PPRQA 881_ SPDLT 886_ ASSAQ 891_ ASVLK 896_ MLQAA 901_ RDMVT 906_ TAGVS 911_ SSLDR 916_ ATRTI 921_ ENWGG 926_ GRRAP 931_ PPSPC 936_ PTPRS 941_ GPSPC 946_ LPTPD 951_ PPPEP 956_ SPTGW 961_ GPPDG 966_ GRAAL 971_ VRRAP 976_ QPPGR 981_ PPTPG 986_ PPLSD 991_ VSRVS 996_ RRPAW 1001_ EARWP 1006_ VRTGH 1011_ CGRHL 1016_ SASER 1021_ PLSPA 1026_ RCHYS 1031_ SFPRA 1036_ DRSGR 1041_ PFLPL 1046_ FPELE 1051_ DLPLL 1056_ GPEQL 1061_ ARREA 1066_ LLHAA 1071_ WARGS 1076_ RPRHA 1081_ SLPSS 1086_ VAEAF 1091_ ARPSS 1096_ LPAGC 1101_ TGPAC 1106_ ARPDG 1111_ HSACR 1116_ RLAQA 1121_ QSMCL 1126_ PIYRE 1131_ ACQEG 1136_ EQAGA 1141_ PAWQH 1146_ RQHVC 1151_ LHAHA 1156_ HLPFC 1161_ WGAVC 1166_ PHLPP 1171_ CASHG 1176_ SWLSG 1181_ AWGPL 1186_ GHRGR 1191_ TLGLG 1196_ TGYRD 1201_ SGGLD 1206_ EISRV 1211_ ARGTQ 1216_ GFPGP 1221_ CTWRR 1226_ISSLE
1: Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:26875626, PubMed:36309015). Participates in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current and long-term synaptic potentiation (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:26875626, PubMed:36309015). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626)