Ras-related protein Rab-39A (Rab-39)
1_METIW 6_ IYQFR 11_ LIVIG 16_ DSTVG 21_ KSCLL 26_ HRFTQ 31_ GRFPG 36_ LRSPA 41_ CDPTV 46_ GVDFF 51_ SRLLE 56_ IEPGK 61_ RIKLQ 66_ LWDTA 71_ GQERF 76_ RSITR 81_ SYYRN 86_ SVGGF 91_ LVFDI 96_ TNRRS 101_ FEHVK 106_ DWLEE 111_ AKMYV 116_ QPFRI 121_ VFLLV 126_ GHKCD 131_ LASQR 136_ QVTRE 141_ EAEKL 146_ SADCG 151_ MKYIE 156_ TSAKD 161_ ATNVE 166_ ESFTI 171_ LTRDI 176_ YELIK 181_ KGEIC 186_ IQDGW 191_ EGVKS 196_ GFVPN 201_ TVHSS 206_ EEAVK 211_PRKEC
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:21255211). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:21255211). RAB39A regulates autophagosome-lysosome fusion via recruitment of the HOPS endosomal tethering complex onto lysosomes; this process involves lysosomal RAB39A and autophagosomal RAB2A recruitment of HOPS subcomplexes VPS41-VPS16-VPS18-VPS33A and VPS39-VPS11, respectively, which assemble into a functional complex to mediate membrane tethering and SNAREs-driven membrane fusion (PubMed:37821429). Also negatively regulates lipopolysaccharide (LPS)-induced autophagosome formation in macrophages, possibly by implicating PI3K (PubMed:24349490). Promotes the delivery of MHC-I molecules from the ER to phagosomes and the generation of peptide-loaded MHC-I complexes in phagosomes, thus enhancing antigen cross-presentation by dendritic cells (By similarity). Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays a role in the fusion of phagosomes with lysosomes (PubMed:21255211). May be involved in multiple neurite formation (By similarity)