Sodium/bile acid cotransporter (Cell growth-inhibiting gene 29 protein) (Na(+)/bile acid cotransporter) (Na(+)/taurocholate transport protein) (Sodium/taurocholate cotransporting polypeptide) (Solute carrier family 10 member 1)
1_MEAHN 6_ ASAPF 11_ NFTLP 16_ PNFGK 21_ RPTDL 26_ ALSVI 31_ LVFML 36_ FFIML 41_ SLGCT 46_ MEFSK 51_ IKAHL 56_ WKPKG 61_ LAIAL 66_ VAQYG 71_ IMPLT 76_ AFVLG 81_ KVFRL 86_ KNIEA 91_ LAILV 96_ CGCSP 101_ GGNLS 106_ NVFSL 111_ AMKGD 116_ MNLSI 121_ VMTTC 126_ STFCA 131_ LGMMP 136_ LLLYI 141_ YSRGI 146_ YDGDL 151_ KDKVP 156_ YKGIV 161_ ISLVL 166_ VLIPC 171_ TIGIV 176_ LKSKR 181_ PQYMR 186_ YVIKG 191_ GMIII 196_ LLCSV 201_ AVTVL 206_ SAINV 211_ GKSIM 216_ FAMTP 221_ LLIAT 226_ SSLMP 231_ FIGFL 236_ LGYVL 241_ SALFC 246_ LNGRC 251_ RRTVS 256_ METGC 261_ QNVQL 266_ CSTIL 271_ NVAFP 276_ PEVIG 281_ PLFFF 286_ PLLYM 291_ IFQLG 296_ EGLLL 301_ IAIFW 306_ CYEKF 311_ KTPKD 316_ KTKMI 321_ YTAAT 326_ TEETI 331_ PGALG 336_ NGTYK 341_GEDCS
1: As a major transporter of conjugated bile salts from plasma into the hepatocyte, it plays a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins (PubMed:14660639, PubMed:24867799, PubMed:34060352, PubMed:8132774). It is strictly dependent on the extracellular presence of sodium (PubMed:14660639, PubMed:24867799, PubMed:34060352, PubMed:8132774). It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate (PubMed:14660639, PubMed:34060352). Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (PubMed:33222321)
2: (Microbial infection) Acts as an entry receptor for hepatitis B virus (HBV) (PubMed:23150796). The recognition for human SLC10A1/NTCP is highly specific (PubMed:35545671, PubMed:35580629, PubMed:35580630, PubMed:38233573)