Importin subunit beta-1 (Importin-90) (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97)
1_MELIT 6_ ILEKT 11_ VSPDR 16_ LELEA 21_ AQKFL 26_ ERAAV 31_ ENLPT 36_ FLVEL 41_ SRVLA 46_ NPGNS 51_ QVARV 56_ AAGLQ 61_ IKNSL 66_ TSKDP 71_ DIKAQ 76_ YQQRW 81_ LAIDA 86_ NARRE 91_ VKNYV 96_ LQTLG 101_ TETYR 106_ PSSAS 111_ QCVAG 116_ IACAE 121_ IPVNQ 126_ WPELI 131_ PQLVA 136_ NVTNP 141_ NSTEH 146_ MKEST 151_ LEAIG 156_ YICQD 161_ IDPEQ 166_ LQDKS 171_ NEILT 176_ AIIQG 181_ MRKEE 186_ PSNNV 191_ KLAAT 196_ NALLN 201_ SLEFT 206_ KANFD 211_ KESER 216_ HFIMQ 221_ VVCEA 226_ TQCPD 231_ TRVRV 236_ AALQN 241_ LVKIM 246_ SLYYQ 251_ YMETY 256_ MGPAL 261_ FAITI 266_ EAMKS 271_ DIDEV 276_ ALQGI 281_ EFWSN 286_ VCDEE 291_ MDLAI 296_ EASEA 301_ AEQGR 306_ PPEHT 311_ SKFYA 316_ KGALQ 321_ YLVPI 326_ LTQTL 331_ TKQDE 336_ NDDDD 341_ DWNPC 346_ KAAGV 351_ CLMLL 356_ ATCCE 361_ DDIVP 366_ HVLPF 371_ IKEHI 376_ KNPDW 381_ RYRDA 386_ AVMAF 391_ GCILE 396_ GPEPS 401_ QLKPL 406_ VIQAM 411_ PTLIE 416_ LMKDP 421_ SVVVR 426_ DTAAW 431_ TVGRI 436_ CELLP 441_ EAAIN 446_ DVYLA 451_ PLLQC 456_ LIEGL 461_ SAEPR 466_ VASNV 471_ CWAFS 476_ SLAEA 481_ AYEAA 486_ DVADD 491_ QEEPA 496_ TYCLS 501_ SSFEL 506_ IVQKL 511_ LETTD 516_ RPDGH 521_ QNNLR 526_ SSAYE 531_ SLMEI 536_ VKNSA 541_ KDCYP 546_ AVQKT 551_ TLVIM 556_ ERLQQ 561_ VLQME 566_ SHIQS 571_ TSDRI 576_ QFNDL 581_ QSLLC 586_ ATLQN 591_ VLRKV 596_ QHQDA 601_ LQISD 606_ VVMAS 611_ LLRMF 616_ QSTAG 621_ SGGVQ 626_ EDALM 631_ AVSTL 636_ VEVLG 641_ GEFLK 646_ YMEAF 651_ KPFLG 656_ IGLKN 661_ YAEYQ 666_ VCLAA 671_ VGLVG 676_ DLCRA 681_ LQSNI 686_ IPFCD 691_ EVMQL 696_ LLENL 701_ GNENV 706_ HRSVK 711_ PQILS 716_ VFGDI 721_ ALAIG 726_ GEFKK 731_ YLEVV 736_ LNTLQ 741_ QASQA 746_ QVDKS 751_ DYDMV 756_ DYLNE 761_ LRESC 766_ LEAYT 771_ GIVQG 776_ LKGDQ 781_ ENVHP 786_ DVMLV 791_ QPRVE 796_ FILSF 801_ IDHIA 806_ GDEDH 811_ TDGVV 816_ ACAAG 821_ LIGDL 826_ CTAFG 831_ KDVLK 836_ LVEAR 841_ PMIHE 846_ LLTEG 851_ RRSKT 856_ NKAKT 861_ LATWA 866_ TKELR 871_KLKNQ
1: Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). Acting autonomously, serves itself as NLS receptor (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:24699649, PubMed:7615630, PubMed:9687515). Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607, PubMed:9687515). In association with IPO7, mediates the nuclear import of H1 histone (PubMed:10228156). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones (By similarity). Imports MRTFA, SNAI1 and PRKCI into the nucleus (PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649)
2: (Microbial infection) In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev