Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130)
1_MADAG 6_ IRRVV 11_ PSDLY 16_ PLVLG 21_ FLRDN 26_ QLSEV 31_ ANKFA 36_ KATGA 41_ TQQDA 46_ NASSL 51_ LDIYS 56_ FWLKS 61_ AKVPE 66_ RKLQA 71_ NGPVA 76_ KKAKK 81_ KASSS 86_ DSEDS 91_ SEEEE 96_ EVQGP 101_ PAKKA 106_ AVPAK 111_ RVGLP 116_ PGKAA 121_ AKASE 126_ SSSSE 131_ ESSDD 136_ DDEED 141_ QKKQP 146_ VQKGV 151_ KPQAK 156_ AAKAP 161_ PKKAK 166_ SSDSD 171_ SDSSS 176_ EDEPP 181_ KNQKP 186_ KITPV 191_ TVKAQ 196_ TKAPP 201_ KPARA 206_ APKIA 211_ NGKAA 216_ SSSSS 221_ SSSSS 226_ SSDDS 231_ EEEKA 236_ AATPK 241_ KTVPK 246_ KQVVA 251_ KAPVK 256_ AATTP 261_ TRKSS 266_ SSEDS 271_ SSDEE 276_ EEQKK 281_ PMKNK 286_ PGPYS 291_ SVPPP 296_ SAPPP 301_ KKSLG 306_ TQPPK 311_ KAVEK 316_ QQPVE 321_ SSEDS 326_ SDESD 331_ SSSEE 336_ EKKPP 341_ TKAVV 346_ SKATT 351_ KPPPA 356_ KKAAE 361_ SSSDS 366_ SDSDS 371_ SEDDE 376_ APSKP 381_ AGTTK 386_ NSSNK 391_ PAVTT 396_ KSPAV 401_ KPAAA 406_ PKQPV 411_ GGGQK 416_ LLTRK 421_ ADSSS 426_ SEEES 431_ SSSEE 436_ EKTKK 441_ MVATT 446_ KPKAT 451_ AKAAL 456_ SLPAK 461_ QAPQG 466_ SRDSS 471_ SDSDS 476_ SSSEE 481_ EEEKT 486_ SKSAV 491_ KKKPQ 496_ KVAGG 501_ AAPSK 506_ PASAK 511_ KGKAE 516_ SSNSS 521_ SSDDS 526_ SEEEE 531_ EKLKG 536_ KGSPR 541_ PQAPK 546_ ANGTS 551_ ALTAQ 556_ NGKAA 561_ KNSEE 566_ EEEEK 571_ KKAAV 576_ VVSKS 581_ GSLKK 586_ RKQNE 591_ AAKEA 596_ ETPQA 601_ KKIKL 606_ QTPNT 611_ FPKRK 616_ KGEKR 621_ ASSPF 626_ RRVRE 631_ EEIEV 636_ DSRVA 641_ DNSFD 646_ AKRGA 651_ AGDWG 656_ ERANQ 661_ VLKFT 666_ KGKSF 671_ RHEKT 676_ KKKRG 681_ SYRGG 686_ SISVQ 691_VNSIK
1: Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786)