Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen)
1_MTLHA 6_ TRGAA 11_ LLSWV 16_ NSLHV 21_ ADPVE 26_ AVLQL 31_ QDCSI 36_ FIKII 41_ DRIHG 46_ TEEGQ 51_ QILKQ 56_ PVSER 61_ LDFVC 66_ SFLQK 71_ NRKHP 76_ SSPEC 81_ LVSAQ 86_ KVLEG 91_ SELEL 96_ AKMTM 101_ LLLYH 106_ STMSS 111_ KSPRD 116_ WEQFE 121_ YKIQA 126_ ELAVI 131_ LKFVL 136_ DHEDG 141_ LNLNE 146_ DLENF 151_ LQKAP 156_ VPSTC 161_ SSTFP 166_ EELSP 171_ PSHQA 176_ KREIR 181_ FLELQ 186_ KVASS 191_ SSGNN 196_ FLSGS 201_ PASPM 206_ GDILQ 211_ TPQFQ 216_ MRRLK 221_ KQLAD 226_ ERSNR 231_ DELEL 236_ ELAEN 241_ RKLLT 246_ EKDAQ 251_ IAMMQ 256_ QRIDR 261_ LALLN 266_ EKQAA 271_ SPLEP 276_ KELEE 281_ LRDKN 286_ ESLTM 291_ RLHET 296_ LKQCQ 301_ DLKTE 306_ KSQMD 311_ RKINQ 316_ LSEEN 321_ GDLSF 326_ KLREF 331_ ASHLQ 336_ QLQDA 341_ LNELT 346_ EEHSK 351_ ATQEW 356_ LEKQA 361_ QLEKE 366_ LSAAL 371_ QDKKC 376_ LEEKN 381_ EILQG 386_ KLSQL 391_ EEHLS 396_ QLQDN 401_ PPQEK 406_ GEVLG 411_ DVLQL 416_ ETLKQ 421_ EAATL 426_ AANNT 431_ QLQAR 436_ VEMLE 441_ TERGQ 446_ QEAKL 451_ LAERG 456_ HFEEE 461_ KQQLS 466_ SLITD 471_ LQSSI 476_ SNLSQ 481_ AKEEL 486_ EQASQ 491_ AHGAR 496_ LTAQV 501_ ASLTS 506_ ELTTL 511_ NATIQ 516_ QQDQE 521_ LAGLK 526_ QQAKE 531_ KQAQL 536_ AQTLQ 541_ QQEQA 546_ SQGLR 551_ HQVEQ 556_ LSSSL 561_ KQKEQ 566_ QLKEV 571_ AEKQE 576_ ATRQD 581_ HAQQL 586_ ATAAE 591_ EREAS 596_ LRERD 601_ AALKQ 606_ LEALE 611_ KEKAA 616_ KLEIL 621_ QQQLQ 626_ VANEA 631_ RDSAQ 636_ TSVTQ 641_ AQREK 646_ AELSR 651_ KVEEL 656_ QACVE 661_ TARQE 666_ QHEAQ 671_ AQVAE 676_ LELQL 681_ RSEQQ 686_ KATEK 691_ ERVAQ 696_ EKDQL 701_ QEQLQ 706_ ALKES 711_ LKVTK 716_ GSLEE 721_ EKRRA 726_ ADALE 731_ EQQRC 736_ ISELK 741_ AETRS 746_ LVEQH 751_ KRERK 756_ ELEEE 761_ RAGRK 766_ GLEAR 771_ LQQLG 776_ EAHQA 781_ ETEVL 786_ RRELA 791_ EAMAA 796_ QHTAE 801_ SECEQ 806_ LVKEV 811_ AAWRE 816_ RYEDS 821_ QQEEA 826_ QYGAM 831_ FQEQL 836_ MTLKE 841_ ECEKA 846_ RQELQ 851_ EAKEK 856_ VAGIE 861_ SHSEL 866_ QISRQ 871_ QNELA 876_ ELHAN 881_ LARAL 886_ QQVQE 891_ KEVRA 896_ QKLAD 901_ DLSTL 906_ QEKMA 911_ ATSKE 916_ VARLE 921_ TLVRK 926_ AGEQQ 931_ ETASR 936_ ELVKE 941_ PARAG 946_ DRQPE 951_ WLEEQ 956_ QGRQF 961_ CSTQA 966_ ALQAM 971_ EREAE 976_ QMGNE 981_ LERLR 986_ AALME 991_ SQGQQ 996_ QEERG 1001_ QQERE 1006_ VARLT 1011_ QERGR 1016_ AQADL 1021_ ALEKA 1026_ ARAEL 1031_ EMRLQ 1036_ NALNE 1041_ QRVEF 1046_ ATLQE 1051_ ALAHA 1056_ LTEKE 1061_ GKDQE 1066_ LAKLR 1071_ GLEAA 1076_ QIKEL 1081_ EELRQ 1086_ TVKQL 1091_ KEQLA 1096_ KKEKE 1101_ HASGS 1106_ GAQSE 1111_ AAGRT 1116_ EPTGP 1121_ KLEAL 1126_ RAEVS 1131_ KLEQQ 1136_ CQKQQ 1141_ EQADS 1146_ LERSL 1151_ EAERA 1156_ SRAER 1161_ DSALE 1166_ TLQGQ 1171_ LEEKA 1176_ QELGH 1181_ SQSAL 1186_ ASAQR 1191_ ELAAF 1196_ RTKVQ 1201_ DHSKA 1206_ EDEWK 1211_ AQVAR 1216_ GRQEA 1221_ ERKNS 1226_ LISSL 1231_ EEEVS 1236_ ILNRQ 1241_ VLEKE 1246_ GESKE 1251_ LKRLV 1256_ MAESE 1261_ KSQKL 1266_ EERLR 1271_ LLQAE 1276_ TASNS 1281_ ARAAE 1286_ RSSAL 1291_ REEVQ 1296_ SLREE 1301_ AEKQR 1306_ VASEN 1311_ LRQEL 1316_ TSQAE 1321_ RAEEL 1326_ GQELK 1331_ AWQEK 1336_ FFQKE 1341_ QALST 1346_ LQLEH 1351_ TSTQA 1356_ LVSEL 1361_ LPAKH 1366_ LCQQL 1371_ QAEQA 1376_ AAEKR 1381_ HREEL 1386_ EQSKQ 1391_ AAGGL 1396_ RAELL 1401_ RAQRE 1406_ LGELI 1411_ PLRQK 1416_ VAEQE 1421_ RTAQQ 1426_ LRAEK 1431_ ASYAE 1436_ QLSML 1441_ KKAHG 1446_ LLAEE 1451_ NRGLG 1456_ ERANL 1461_ GRQFL 1466_ EVELD 1471_ QAREK 1476_ YVQEL 1481_ AAVRA 1486_ DAETR 1491_ LAEVQ 1496_ REAQS 1501_ TAREL 1506_ EVMTA 1511_ KYEGA 1516_ KVKVL 1521_ EERQR 1526_ FQEER 1531_ QKLTA 1536_ QVEQL 1541_ EVFQR 1546_ EQTKQ 1551_ VEELS 1556_ KKLAD 1561_ SDQAS 1566_ KVQQQ 1571_ KLKAV 1576_ QAQGG 1581_ ESQQE 1586_ AQRLQ 1591_ AQLNE 1596_ LQAQL 1601_ SQKEQ 1606_ AAEHY 1611_ KLQME 1616_ KAKTH 1621_ YDAKK 1626_ QQNQE 1631_ LQEQL 1636_ RSLEQ 1641_ LQKEN 1646_ KELRA 1651_ EAERL 1656_ GHELQ 1661_ QAGLK 1666_ TKEAE 1671_ QTCRH 1676_ LTAQV 1681_ RSLEA 1686_ QVAHA 1691_ DQQLR 1696_ DLGKF 1701_ QVATD 1706_ ALKSR 1711_ EPQAK 1716_ PQLDL 1721_ SIDSL 1726_ DLSCE 1731_ EGTPL 1736_ SITSK 1741_ LPRTQ 1746_ PDGTS 1751_ VPGEP 1756_ ASPIS 1761_ QRLPP 1766_ KVESL 1771_ ESLYF 1776_ TPIPA 1781_ RSQAP 1786_ LESSL 1791_ DSLGD 1796_ VFLDS 1801_ GRKTR 1806_ SARRR 1811_ TTQII 1816_ NITMT 1821_ KKLDV 1826_ EEPDS 1831_ ANSSF 1836_ YSTRS 1841_ APASQ 1846_ ASLRA 1851_ TSSTQ 1856_ SLARL 1861_ GSPDY 1866_ GNSAL 1871_ LSLPG 1876_ YRPTT 1881_ RSSAR 1886_ RSQAG 1891_ VSSGA 1896_ PPGRN 1901_ SFYMG 1906_ TCQDE 1911_ PEQLD 1916_ DWNRI 1921_ AELQQ 1926_ RNRVC 1931_ PPHLK 1936_ TCYPL 1941_ ESRPS 1946_ LSLGT 1951_ ITDEE 1956_ MKTGD 1961_ PQETL 1966_ RRASM 1971_ QPIQI 1976_ AEGTG 1981_ ITTRQ 1986_ QRKRV 1991_ SLEPH 1996_ QGPGT 2001_ PESKK 2006_ ATSCF 2011_ PRPMT 2016_ PRDRH 2021_ EGRKQ 2026_ STTEA 2031_ QKKAA 2036_ PASTK 2041_ QADRR 2046_ QSMAF 2051_ SILNT 2056_ PKKLG 2061_ NSLLR 2066_ RGASK 2071_ KALSK 2076_ ASPNT 2081_ RSGTR 2086_ RSPRI 2091_ ATTTA 2096_ SAATA 2101_ AAIGA 2106_TPRAK
1: Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity)