Proteasome activator complex subunit 4 (Proteasome activator PA200)
1_MEPAE 6_ RAGVG 11_ EPPEP 16_ GGRPE 21_ PGPRG 26_ FVPQK 31_ EIVYN 36_ KLLPY 41_ AERLD 46_ AESDL 51_ QLAQI 56_ KCNLG 61_ RAVQL 66_ QELWP 71_ GGLFW 76_ TRKLS 81_ TYIRL 86_ YGRKF 91_ SKEDH 96_ VLFIK 101_ LLYEL 106_ VSIPK 111_ LEISM 116_ MQGFA 121_ RLLIN 126_ LLKKK 131_ ELLSR 136_ ADLEL 141_ PWRPL 146_ YDMVE 151_ RILYS 156_ KTEHL 161_ GLNWF 166_ PNSVE 171_ NILKT 176_ LVKSC 181_ RPYFP 186_ ADATA 191_ EMLEE 196_ WRPLM 201_ CPFDV 206_ TMQKA 211_ ITYFE 216_ IFLPT 221_ SLPPE 226_ LHHKG 231_ FKLWF 236_ DELIG 241_ LWVSV 246_ QNLPQ 251_ WEGQL 256_ VNLFA 261_ RLATD 266_ NIGYI 271_ DWDPY 276_ VPKIF 281_ TRILR 286_ SLNLP 291_ VGSSQ 296_ VLVPR 301_ FLTNA 306_ YDIGH 311_ AVIWI 316_ TAMMG 321_ GPSKL 326_ VQKHL 331_ AGLFN 336_ SITSF 341_ YHPSN 346_ NGRWL 351_ NKLMK 356_ LLQRL 361_ PNSVV 366_ RRLHR 371_ ERYKK 376_ PSWLT 381_ PVPDS 386_ HKLTD 391_ QDVTD 396_ FVQCI 401_ IQPVL 406_ LAMFS 411_ KTGSL 416_ EAAQA 421_ LQNLA 426_ LMRPE 431_ LVIPP 436_ VLERT 441_ YPALE 446_ TLTEP 451_ HQLTA 456_ TLSCV 461_ IGVAR 466_ SLVSG 471_ GRWFP 476_ EGPTH 481_ MLPLL 486_ MRALP 491_ GVDPN 496_ DFSKC 501_ MITFQ 506_ FIATF 511_ STLVP 516_ LVDCS 521_ SVLQE 526_ RNDLT 531_ EVERE 536_ LCSAT 541_ AEFED 546_ FVLQF 551_ MDRCF 556_ GLIES 561_ STLEQ 566_ TREET 571_ ETEKM 576_ THLES 581_ LVELG 586_ LSSTF 591_ STILT 596_ QCSKE 601_ IFMVA 606_ LQKVF 611_ NFSTS 616_ HIFET 621_ RVAGR 626_ MVADM 631_ CRAAV 636_ KCCPE 641_ ESLKL 646_ FVPHC 651_ CSVIT 656_ QLTMN 661_ DDVLN 666_ DEELD 671_ KELLW 676_ NLQLL 681_ SEITR 686_ VDGRK 691_ LLLYR 696_ EQLVK 701_ ILQRT 706_ LHLTC 711_ KQGYT 716_ LSCNL 721_ LHHLL 726_ RSTTL 731_ IYPTE 736_ YCSVP 741_ GGFDK 746_ PPSEY 751_ FPIKD 756_ WGKPG 761_ DLWNL 766_ GIQWH 771_ VPSSE 776_ EVSFA 781_ FYLLD 786_ SFLQP 791_ ELVKL 796_ QHCGD 801_ GKLEM 806_ SRDDI 811_ LQSLT 816_ IVHNC 821_ LIGSG 826_ NLLPP 831_ LKGEP 836_ VTNLV 841_ PSMVS 846_ LEETK 851_ LYTGL 856_ EYDLS 861_ RENHR 866_ EVIAT 871_ VIRKL 876_ LNHIL 881_ DNSED 886_ DTKSL 891_ FLIIK 896_ IIGDL 901_ LQFQG 906_ SHKHE 911_ FDSRW 916_ KSFNL 921_ VKKSM 926_ ENRLH 931_ GKKQH 936_ IRALL 941_ IDRVM 946_ LQHEL 951_ RTLTV 956_ EGCEY 961_ KKIHQ 966_ DMIRD 971_ LLRLS 976_ TSSYS 981_ QVRNK 986_ AQQTF 991_ FAALG 996_ AYNFC 1001_ CRDII 1006_ PLVLE 1011_ FLRPD 1016_ RQGVT 1021_ QQQFK 1026_ GALYC 1031_ LLGNH 1036_ SGVCL 1041_ ANLHD 1046_ WDCIV 1051_ QTWPA 1056_ IVSSG 1061_ LSQAM 1066_ SLEKP 1071_ SIVRL 1076_ FDDLA 1081_ EKIHR 1086_ QYETI 1091_ GLDFT 1096_ IPKSC 1101_ VEIAE 1106_ LLQQS 1111_ KNPSI 1116_ NQILL 1121_ SPEKI 1126_ KEGIK 1131_ RQQEK 1136_ NADAL 1141_ RNYEN 1146_ LVDTL 1151_ LDGVE 1156_ QRNLP 1161_ WKFEH 1166_ IGIGL 1171_ LSLLL 1176_ RDDRV 1181_ LPLRA 1186_ IRFFV 1191_ ENLNH 1196_ DAIVV 1201_ RKMAI 1206_ SAVAG 1211_ ILKQL 1216_ KRTHK 1221_ KLTIN 1226_ PCEIS 1231_ GCPKP 1236_ TQIIA 1241_ GDRPD 1246_ NHWLH 1251_ YDSKT 1256_ IPRTK 1261_ KEWES 1266_ SCFVE 1271_ KTHWG 1276_ YYTWP 1281_ KNMVV 1286_ YAGVE 1291_ EQPKL 1296_ GRSRE 1301_ DMTEA 1306_ EQIIF 1311_ DHFSD 1316_ PKFVE 1321_ QLITF 1326_ LSLED 1331_ RKGKD 1336_ KFNPR 1341_ RFCLF 1346_ KGIFR 1351_ NFDDA 1356_ FLPVL 1361_ KPHLE 1366_ HLVAD 1371_ SHEST 1376_ QRCVA 1381_ EIIAG 1386_ LIRGS 1391_ KHWTF 1396_ EKVEK 1401_ LWELL 1406_ CPLLR 1411_ TALSN 1416_ ITVET 1421_ YNDWG 1426_ ACIAT 1431_ SCESR 1436_ DPRKL 1441_ HWLFE 1446_ LLLES 1451_ PLSGE 1456_ GGSFV 1461_ DACRL 1466_ YVLQG 1471_ GLAQQ 1476_ EWRVP 1481_ ELLHR 1486_ LLKYL 1491_ EPKLT 1496_ QVYKN 1501_ VRERI 1506_ GSVLT 1511_ YIFMI 1516_ DVSLP 1521_ NTTPT 1526_ ISPHV 1531_ PEFTA 1536_ RILEK 1541_ LKPLM 1546_ DVDEE 1551_ IQNHV 1556_ MEENG 1561_ IGEED 1566_ ERTQG 1571_ IKLLK 1576_ TILKW 1581_ LMASA 1586_ GRSFS 1591_ TAVTE 1596_ QLQLL 1601_ PLFFK 1606_ IAPVE 1611_ NDNSY 1616_ DELKR 1621_ DAKLC 1626_ LSLMS 1631_ QGLLY 1636_ PHQVP 1641_ LVLQV 1646_ LKQTA 1651_ RSSSW 1656_ HARYT 1661_ VLTYL 1666_ QTMVF 1671_ YNLFI 1676_ FLNNE 1681_ DAVKD 1686_ IRWLV 1691_ ISLLE 1696_ DEQLE 1701_ VREMA 1706_ ATTLS 1711_ GLLQC 1716_ NFLTM 1721_ DSPMQ 1726_ IHFEQ 1731_ LCKTK 1736_ LPKKR 1741_ KRDPG 1746_ SVGDT 1751_ IPSAE 1756_ LVKRH 1761_ AGVLG 1766_ LGACV 1771_ LSSPY 1776_ DVPTW 1781_ MPQLL 1786_ MNLSA 1791_ HLNDP 1796_ QPIEM 1801_ TVKKT 1806_ LSNFR 1811_ RTHHD 1816_ NWQEH 1821_ KQQFT 1826_ DDQLL 1831_ VLTDL 1836_LVSPC
1: Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks