Cullin-7 (CUL-7)
1_MVGEL 6_ RYREF 11_ RVPLG 16_ PGLHA 21_ YPDEL 26_ IRQRV 31_ GHDGH 36_ PEYQI 41_ RWLIL 46_ RRGDE 51_ GDGGS 56_ GQVDC 61_ KAEHI 66_ LLWMS 71_ KDEIY 76_ ANCHK 81_ MLGED 86_ GQVIG 91_ PSQES 96_ AGEVG 101_ ALDKS 106_ VLEEM 111_ ETDVK 116_ SLIQR 121_ ALRQL 126_ EECVG 131_ TIPPA 136_ PLLHT 141_ VHVLS 146_ AYASI 151_ EPLTG 156_ VFKDP 161_ RVLDL 166_ LMHML 171_ SSPDY 176_ QIRWS 181_ AGRMI 186_ QALSS 191_ HDAGT 196_ RTQIL 201_ LSLSQ 206_ QEAIE 211_ KHLDF 216_ DSRCA 221_ LLALF 226_ AQATL 231_ SEHPM 236_ SFEGI 241_ QLPQV 246_ PGRVL 251_ FSLVK 256_ RYLHV 261_ TSLLD 266_ QLNDS 271_ AAEPG 276_ AQNTS 281_ APEEL 286_ SGERG 291_ QLELE 296_ FSMAM 301_ GTLIS 306_ ELVQA 311_ MRWDQ 316_ ASDRP 321_ RSSAR 326_ SPGSI 331_ FQPQL 336_ ADVSP 341_ GLPAA 346_ QAQPS 351_ FRRSR 356_ RFRPR 361_ SEFAS 366_ GNTYA 371_ LYVRD 376_ TLQPG 381_ MRVRM 386_ LDDYE 391_ EISAG 396_ DEGEF 401_ RQSNN 406_ GVPPV 411_ QVFWE 416_ STGRT 421_ YWVHW 426_ HMLEI 431_ LGFEE 436_ DIEDM 441_ VEADE 446_ YQGAV 451_ ASRVL 456_ GRALP 461_ AWRWR 466_ PMTEL 471_ YAVPY 476_ VLPED 481_ EDTEE 486_ CEHLT 491_ LAEWW 496_ ELLFF 501_ IKKLD 506_ GPDHQ 511_ EVLQI 516_ LQENL 521_ DGEIL 526_ DDEIL 531_ AELAV 536_ PIELA 541_ QDLLL 546_ TLPQR 551_ LNDSA 556_ LRDLI 561_ NCHVY 566_ KKYGP 571_ EALAG 576_ NQAYP 581_ SLLEA 586_ QEDVL 591_ LLDAQ 596_ AQAKD 601_ SEDAA 606_ KVEAK 611_ EPPSQ 616_ SPNTP 621_ LQRLV 626_ EGYGP 631_ AGKIL 636_ LDLEQ 641_ ALSSE 646_ GTQEN 651_ KVKPL 656_ LLQLQ 661_ RQPQP 666_ FLALM 671_ QSLDT 676_ PETNR 681_ TLHLT 686_ VLRIL 691_ KQLVD 696_ FPEAL 701_ LLPWH 706_ EAVDA 711_ CMACL 716_ RSPNT 721_ DREVL 726_ QELIF 731_ FLHRL 736_ TSVSR 741_ DYAVV 746_ LNQLG 751_ ARDAI 756_ SKALE 761_ KHLGK 766_ LELAQ 771_ ELRDM 776_ VFKCE 781_ KHAHL 786_ YRKLI 791_ TNILG 796_ GCIQM 801_ VLGQI 806_ EDHRR 811_ THQPI 816_ NIPFF 821_ DVFLR 826_ YLCQG 831_ SSVEV 836_ KEDKC 841_ WEKVE 846_ VSSNP 851_ HRASK 856_ LTDHN 861_ PKTYW 866_ ESNGS 871_ AGSHY 876_ ITLHM 881_ RRGIL 886_ IRQLT 891_ LLVAS 896_ EDSSY 901_ MPARV 906_ VVCGG 911_ DSTSS 916_ LHTEL 921_ NSVNV 926_ MPSAS 931_ RVILL 936_ ENLTR 941_ FWPII 946_ QIRIK 951_ RCQQG 956_ GIDTR 961_ IRGLE 966_ ILGPK 971_ PTFWP 976_ VFREQ 981_ LCRHT 986_ RLFYM 991_ VRAQA 996_ WSQDM 1001_ AEDRR 1006_ SLLHL 1011_ SSRLN 1016_ GALRQ 1021_ EQNFA 1026_ DRFLP 1031_ DDEAA 1036_ QALGK 1041_ TCWEA 1046_ LVSPV 1051_ VQNIT 1056_ SPDED 1061_ GISPL 1066_ GWLLD 1071_ QYLEC 1076_ QEAVF 1081_ NPQSR 1086_ GPAFF 1091_ SRVRR 1096_ LTHLL 1101_ VHVEP 1106_ CEAPP 1111_ PVVAT 1116_ PRPKG 1121_ RNRSH 1126_ DWSSL 1131_ ATRGL 1136_ PSSIM 1141_ RNLTR 1146_ CWRAV 1151_ VEKQV 1156_ NNFLT 1161_ SSWRD 1166_ DDFVP 1171_ RYCEH 1176_ FNILQ 1181_ NSSSE 1186_ LFGPR 1191_ AAFLL 1196_ ALQNG 1201_ CAGAL 1206_ LKLPF 1211_ LKAAH 1216_ VSEQF 1221_ ARHID 1226_ QQIQG 1231_ SRIGG 1236_ AQEME 1241_ RLAQL 1246_ QQCLQ 1251_ AVLIF 1256_ SGLEI 1261_ ATTFE 1266_ HYYQH 1271_ YMADR 1276_ LLGVV 1281_ SSWLE 1286_ GAVLE 1291_ QIGPC 1296_ FPNRL 1301_ PQQML 1306_ QSLST 1311_ SKELQ 1316_ RQFHV 1321_ YQLQQ 1326_ LDQEL 1331_ LKLED 1336_ TEKKI 1341_ QVGLG 1346_ ASGKE 1351_ HKSEK 1356_ EEEAG 1361_ AAAVV 1366_ DVAEG 1371_ EEEEE 1376_ ENEDL 1381_ YYEGA 1386_ MPEVS 1391_ VLVLS 1396_ RHSWP 1401_ VASIC 1406_ HTLNP 1411_ RTCLP 1416_ SYLRG 1421_ TLNRY 1426_ SNFYN 1431_ KSQSH 1436_ PALER 1441_ GSQRR 1446_ LQWTW 1451_ LGWAE 1456_ LQFGN 1461_ QTLHV 1466_ STVQM 1471_ WLLLY 1476_ LNDLK 1481_ AVSVE 1486_ SLLAF 1491_ SGLSA 1496_ DMLNQ 1501_ AIGPL 1506_ TSSRG 1511_ PLDLH 1516_ EQKDI 1521_ PGGVL 1526_ KIRDG 1531_ SKEPR 1536_ SRWDI 1541_ VRLIP 1546_ PQTYL 1551_ QAEGE 1556_ DGQNL 1561_ EKRRN 1566_ LLNCL 1571_ IVRIL 1576_ KAHGD 1581_ EGLHI 1586_ DQLVC 1591_ LVLEA 1596_ WQKGP 1601_ CPPRG 1606_ LVSSL 1611_ GKGSA 1616_ CSSTD 1621_ VLSCI 1626_ LHLLG 1631_ KGTLR 1636_ RHDDR 1641_ PQVLS 1646_ YAVPV 1651_ TVMEP 1656_ HTESL 1661_ NPGSS 1666_ GPNPP 1671_ LTFHT 1676_ LQIRS 1681_ RGVPY 1686_ ASCTA 1691_TQSFS
1: Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:12481031, PubMed:12904573, PubMed:21572988, PubMed:21737058, PubMed:24793695, PubMed:35982156). Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity (PubMed:21572988, PubMed:21737058, PubMed:24793695). It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695). The Cul7-RING(FBXW8) complex alone lacks ubiquitination activity and does not promote polyubiquitination and proteasomal degradation of p53/TP53 (PubMed:16547496, PubMed:17332328, PubMed:35982156). However it mediates recruitment of p53/TP53 for ubiquitination by neddylated CUL1-RBX1 (PubMed:35982156). Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (PubMed:24793696). The Cul7-RING(FBXW8) complex also mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 (PubMed:21572988, PubMed:24362026). Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development (PubMed:20139075). While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may have additional functions. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation