E3 ubiquitin-protein ligase SHPRH (EC 2.3.2.27) (EC 3.6.4.-) (RING-type E3 ubiquitin transferase SHPRH) (SNF2, histone-linker, PHD and RING finger domain-containing helicase)
1_MSSRR 6_ KRAPP 11_ VRVDE 16_ EKRQQ 21_ LHWNM 26_ HEDRR 31_ NEPII 36_ ISDDD 41_ EQPCP 46_ GSDTS 51_ SAHYI 56_ ILSDS 61_ LKEEV 66_ AHRDK 71_ KRCSK 76_ VVSFS 81_ KPIEK 86_ EETVG 91_ IFSPL 96_ SVKLN 101_ IVISP 106_ YHFDN 111_ SWKAF 116_ LGELT 121_ LQLLP 126_ AQSLI 131_ ENFSE 136_ RSITL 141_ MSSES 146_ SNQFL 151_ IYVHS 156_ KGEDV 161_ EKQKK 166_ EPMSI 171_ CDKGI 176_ LVESS 181_ FSGEM 186_ LEDLG 191_ WLQKK 196_ RRIKL 201_ YQKPE 206_ GNHII 211_ KVGIY 216_ LLEAG 221_ LAKLD 226_ FLSDA 231_ NSRMK 236_ KFNQL 241_ MKKVM 246_ EKLHN 251_ SIIPD 256_ VLEED 261_ EDDPE 266_ SEPEG 271_ QDIDE 276_ LYHFV 281_ KQTHQ 286_ QETQS 291_ IQVDV 296_ QHPAL 301_ IPVLR 306_ PYQRE 311_ AVNWM 316_ LQQEC 321_ FRSSP 326_ ATESA 331_ LHFLW 336_ REIVT 341_ SEGLK 346_ LYYNP 351_ YTGCI 356_ IREYP 361_ NSGPQ 366_ LLGGI 371_ LADEM 376_ GLGKT 381_ VEVLA 386_ LILTH 391_ TRQDV 396_ KQDAL 401_ TLPEG 406_ KVVNY 411_ FIPSH 416_ YFGGK 421_ LKKTE 426_ IQNIE 431_ FEPKE 436_ KVQCP 441_ PTRVM 446_ ILTAV 451_ KEMNG 456_ KKGVS 461_ ILSIY 466_ KYVSS 471_ IYRYD 476_ VQRNR 481_ SLLKR 486_ MLKCL 491_ IFEGL 496_ VKQIK 501_ GHGFS 506_ GTFTL 511_ GKNYK 516_ EEDIC 521_ DKTKK 526_ QAVGS 531_ PRKIQ 536_ KETRK 541_ SGNKD 546_ TDSEY 551_ LPSDT 556_ SDDDD 561_ DPYYY 566_ YYKSR 571_ RNRSK 576_ LRKKL 581_ VPSTK 586_ KGKSQ 591_ PFINP 596_ DSQGH 601_ CPATS 606_ DSGIT 611_ DVAMS 616_ KSTCI 621_ SEFNQ 626_ EHETE 631_ DCAES 636_ LNHAD 641_ SDVPP 646_ SNTMS 651_ PFNTS 656_ DYRFE 661_ CICGE 666_ LDQID 671_ RKPRV 676_ QCLKC 681_ HLWQH 686_ AKCVN 691_ YDEKN 696_ LKIKP 701_ FYCPH 706_ CLVAM 711_ EPVST 716_ RATLI 721_ ISPSS 726_ ICHQW 731_ VDEIN 736_ RHVRS 741_ SSLRV 746_ LVYQG 751_ VKKDG 756_ FLQPH 761_ FLAEQ 766_ DIVII 771_ TYDVL 776_ RSELN 781_ YVDIP 786_ HSNSE 791_ DGRRL 796_ RNQKR 801_ YMAIP 806_ SPLVA 811_ VEWWR 816_ ICLDE 821_ AQMVE 826_ CPTVK 831_ AAEMA 836_ QRLSG 841_ INRWC 846_ ISGTP 851_ VQRGL 856_ EDLFG 861_ LVVFL 866_ GIEPY 871_ CVKHW 876_ WVRLL 881_ YRPYC 886_ KKNPQ 891_ HLYSF 896_ IAKIL 901_ WRSAK 906_ KDVID 911_ QIQIP 916_ PQTEE 921_ IHWLH 926_ FSPVE 931_ RHFYH 936_ RQHEV 941_ CCQDV 946_ VVKLR 951_ KISDW 956_ ALKLS 961_ SLDRR 966_ TVTSI 971_ LYPLL 976_ RLRQA 981_ CCHPQ 986_ AVRGE 991_ FLPLQ 996_ KSTMT 1001_ MEELL 1006_ TSLQK 1011_ KCGTE 1016_ CEEAH 1021_ RQLVC 1026_ ALNGL 1031_ AGIHI 1036_ IKGEY 1041_ ALAAE 1046_ LYREV 1051_ LRSSE 1056_ EHKGK 1061_ LKTDS 1066_ LQRLH 1071_ ATHNL 1076_ MELLI 1081_ ARHPG 1086_ IPPTL 1091_ RDGRL 1096_ EEEAK 1101_ QLREH 1106_ YMSKC 1111_ NTEVA 1116_ EAQQA 1121_ LYPVQ 1126_ QTIHE 1131_ LQRKI 1136_ HSNSP 1141_ WWLNV 1146_ IHRAI 1151_ EFTID 1156_ EELVQ 1161_ RVRNE 1166_ ITSNY 1171_ KQQTG 1176_ KLSMS 1181_ EKFRD 1186_ CRGLQ 1191_ FLLTT 1196_ QMEEL 1201_ NKCQK 1206_ LVREA 1211_ VKNLE 1216_ GPPSR 1221_ NVIES 1226_ ATVCH 1231_ LRPAR 1236_ LPLNC 1241_ CVFCK 1246_ ADELF 1251_ TEYES 1256_ KLFSN 1261_ TVKGQ 1266_ TAIFE 1271_ EMIED 1276_ EEGLV 1281_ DDRAP 1286_ TTTRG 1291_ LWAIS 1296_ ETERS 1301_ MKAIL 1306_ SFAKS 1311_ HRFDV 1316_ EFVDE 1321_ GSTSM 1326_ DLFEA 1331_ WKKEY 1336_ KLLHE 1341_ YWMAL 1346_ RNRVS 1351_ AVDEL 1356_ AMATE 1361_ RLRVR 1366_ DPREP 1371_ KPNPP 1376_ VLHII 1381_ EPHEV 1386_ EQNRI 1391_ KLLND 1396_ KAVAT 1401_ SQLQK 1406_ KLGQL 1411_ LYLTN 1416_ LEKSQ 1421_ DKTSG 1426_ GVNPE 1431_ PCPIC 1436_ ARQLG 1441_ KQWAV 1446_ LTCGH 1451_ CFCNE 1456_ CISII 1461_ IEQYS 1466_ VGSHR 1471_ SSIKC 1476_ AICRQ 1481_ TTSHK 1486_ EISYV 1491_ FTSEK 1496_ ANQEE 1501_ DIPVK 1506_ GSHST 1511_ KVEAV 1516_ VRTLM 1521_ KIQLR 1526_ DPGAK 1531_ ALVFS 1536_ TWQDV 1541_ LDIIS 1546_ KALTD 1551_ NNMEF 1556_ AQISR 1561_ VKTFQ 1566_ ENLSA 1571_ FKRDP 1576_ QINIL 1581_ LLPLH 1586_ TGSNG 1591_ LTIIE 1596_ ATHVL 1601_ LVEPI 1606_ LNPAH 1611_ ELQAI 1616_ GRVHR 1621_ IGQTK 1626_ PTIVH 1631_ RFLIK 1636_ ATIEE 1641_ RMQAM 1646_ LKTAE 1651_ RSHTN 1656_ SSAKH 1661_ SEASV 1666_ LTVAD 1671_ LADLF 1676_TKETE
1: E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'