GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6)
1_MVKLD 6_ IHTLA 11_ HHLKQ 16_ ERLYV 21_ NSEKQ 26_ LIQRL 31_ NADVL 36_ KTAEK 41_ LYRTA 46_ WIAKQ 51_ QRINL 56_ DRLII 61_ TSAEA 66_ SPAEC 71_ CQHAK 76_ ILEDT 81_ QFVDG 86_ YKQLG 91_ FQETA 96_ YGEFL 101_ SRLRE 106_ NPRLI 111_ ASSLV 116_ AGEKL 121_ NQENT 126_ QSVIY 131_ TVFTS 136_ LYGNC 141_ IMQED 146_ ESYLL 151_ QVLRY 156_ LIEFE 161_ LKESD 166_ NPRRL 171_ LRRGT 176_ CAFSI 181_ LFKLF 186_ SEGLF 191_ SAKLF 196_ LTATL 201_ HEPIM 206_ QLLVE 211_ DEDHL 216_ ETDPN 221_ KLIER 226_ FSPSQ 231_ QEKLF 236_ GEKGS 241_ DRFRQ 246_ KVQEM 251_ VESNE 256_ AKLVA 261_ LVNKF 266_ IGYLK 271_ QNTYC 276_ FPHSL 281_ RWIVS 286_ QMYKT 291_ LSCVD 296_ RLEVG 301_ EVRAM 306_ CTDLL 311_ LACFI 316_ CPAVV 321_ NPEQY 326_ GIISD 331_ APINE 336_ VARFN 341_ LMQVG 346_ RLLQQ 351_ LAMTG 356_ SEEGD 361_ PRTKS 366_ SLGKF 371_ DKSCV 376_ AAFLD 381_ VVIGG 386_ RAVET 391_ PPLSS 396_ VNLLE 401_ GLSRT 406_ VVYIT 411_ YSQLI 416_ TLVNF 421_ MKSVM 426_ SGDQL 431_ REDRM 436_ ALDNL 441_ LANLP 446_ PAKPG 451_ KSSSL 456_ EMTPY 461_ NTPQL 466_ SPATT 471_ PANKK 476_ NRLPI 481_ ATRSR 486_ SRTNM 491_ LMDLH 496_ MDHEG 501_ SSQET 506_ IQEVQ 511_ PEEVL 516_ VISLG 521_ TGPQL 526_ TPGMM 531_ SENEV 536_ LNMQL 541_ SDGGQ 546_ GDVPV 551_ DENKL 556_ HGKPD 561_ KTLRF 566_ SLCSD 571_ NLEGI 576_ SEGPS 581_ NRSNS 586_ VSSLD 591_ LEGES 596_ VSELG 601_ AGPSG 606_ SNGVE 611_ ALQLL 616_ EHEQA 621_ TTQDN 626_ LDDKL 631_ RKFEI 636_ RDMMG 641_ LTDDR 646_ DISET 651_ VSETW 656_ STDVL 661_ GSDFD 666_ PNIDE 671_ DRLQE 676_ IAGAA 681_ AENML 686_ GSLLC 691_ LPGSG 696_ SVLLD 701_ PCTGS 706_ TISET 711_ TSEAW 716_ SVEVL 721_ PSDSE 726_ APDLK 731_ QEERL 736_ QELES 741_ CSGLG 746_ STSDD 751_ TDVRE 756_ VSSRP 761_ STPGL 766_ SVVSG 771_ ISATS 776_ EDIPN 781_ KIEDL 786_ RSECS 791_ SDFGG 796_ KDSVT 801_ SPDMD 806_ EITHG 811_ AHQLT 816_ SPPSQ 821_ SESLL 826_ AMFDP 831_ LSSHE 836_ GASAV 841_ VRPKV 846_ HYARP 851_ SHPPP 856_ DPPIL 861_ EGAVG 866_ GNEAR 871_ LPNFG 876_ SHVLT 881_ PAEME 886_ AFKQR 891_ HSYPE 896_ RLVRS 901_ RSSDI 906_ VSSVR 911_ RPMSD 916_ PSWNR 921_ RPGNE 926_ ERELP 931_ PAAAI 936_ GATSL 941_ VAAPH 946_ SSSSS 951_ PSKDS 956_ SRGET 961_ EERKD 966_ SDDEK 971_ SDRNR 976_ PWWRK 981_ RFVSA 986_ MPKAP 991_ IPFRK 996_ KEKQE 1001_ KDKDD 1006_ LGPDR 1011_ FSTLT 1016_ DDPSP 1021_ RLSAQ 1026_ AQVAE 1031_ DILDK 1036_ YRNAI 1041_ KRTSP 1046_ SDGAM 1051_ ANYES 1056_ TGDNH 1061_ DRDLS 1066_ SKLLY 1071_ HSDKE 1076_ VMGDG 1081_ ESAHD 1086_ SPRDE 1091_ ALQNI 1096_ SADDL 1101_ PDSAS 1106_ QAAHP 1111_ QDSAF 1116_ SYRDA 1121_ KKKLR 1126_ LALCS 1131_ ADSVA 1136_ FPVLT 1141_ HSTRN 1146_ GLPDH 1151_ TDPED 1156_ NEIVC 1161_ FLKVQ 1166_ IAEAI 1171_ NLQDK 1176_ NLMAQ 1181_ LQETM 1186_ RCVCR 1191_ FDNRT 1196_ CRKLL 1201_ ASIAE 1206_ DYRKR 1211_ APYIA 1216_ YLTRC 1221_ RQGLQ 1226_ TTQAH 1231_ LERLL 1236_ QRVLR 1241_ DKEVA 1246_ NRYFT 1251_ TVCVR 1256_ LLLES 1261_ KEKKI 1266_ REFIQ 1271_ DFQKL 1276_ TAADD 1281_ KTAQV 1286_ EDFLQ 1291_ FLYGA 1296_ MAQDV 1301_ IWQNA 1306_ SEEQL 1311_ QDAQL 1316_ AIERS 1321_ VMNRI 1326_ FKLAF 1331_ YPNQD 1336_ GDILR 1341_ DQVLH 1346_ EHIQR 1351_ LSKVV 1356_ TANHR 1361_ ALQIP 1366_ EVYLR 1371_ EAPWP 1376_ SAQSE 1381_ IRTIS 1386_ AYKTP 1391_ RDKVQ 1396_ CILRM 1401_ CSTIM 1406_ NLLSL 1411_ ANEDS 1416_ VPGAD 1421_ DFVPV 1426_ LVFVL 1431_ IKANP 1436_ PCLLS 1441_ TVQYI 1446_ SSFYA 1451_ SCLSG 1456_ EESYW 1461_ WMQFT 1466_ AAVEF 1471_IKTID
1: Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras