UBX domain-containing protein 2B (NSFL1 cofactor p37) (p97 cofactor p37)
1_MAEGG 6_ GPEPG 11_ EQERR 16_ SSGPR 21_ PPSAR 26_ DLQLA 31_ LAELY 36_ EDEVK 41_ CKSSK 46_ SNRPK 51_ ATVFK 56_ SPRTP 61_ PQRFY 66_ SSEHE 71_ YSGLN 76_ IVRPS 81_ TGKIV 86_ NELFK 91_ EAREH 96_ GAVPL 101_ NEATR 106_ ASGDD 111_ KSKSF 116_ TGGGY 121_ RLGSS 126_ FCKRS 131_ EYIYG 136_ ENQLQ 141_ DVQIL 146_ LKLWS 151_ NGFSL 156_ DDGEL 161_ RPYNE 166_ PTNAQ 171_ FLESV 176_ KRGEI 181_ PLELQ 186_ RLVHG 191_ GQVNL 196_ DMEDH 201_ QDQEY 206_ IKPRL 211_ RFKAF 216_ SGEGQ 221_ KLGSL 226_ TPEIV 231_ STPSS 236_ PEEED 241_ KSILN 246_ AVVLI 251_ DDSVP 256_ TTKIQ 261_ IRLAD 266_ GSRLI 271_ QRFNS 276_ THRIL 281_ DVRNF 286_ IVQSR 291_ PEFAA 296_ LDFIL 301_ VTSFP 306_ NKELT 311_ DESLT 316_ LLEAD 321_ ILNTV 326_LLQQL
1: Adapter protein required for Golgi and endoplasmic reticulum biogenesis (PubMed:17141156). Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis (PubMed:17141156). The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L (PubMed:17141156). VCPIP1 is also required, but not its deubiquitinating activity (PubMed:17141156). Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807)