Ataxin-7-like protein 3 (SAGA-associated factor 11 homolog)
1_MKMEE 6_ MSLSG 11_ LDNSK 16_ LEAIA 21_ QEIYA 26_ DLVED 31_ SCLGF 36_ CFEVH 41_ RAVKC 46_ GYFFL 51_ DDTDP 56_ DSMKD 61_ FEIVD 66_ QPGLD 71_ IFGQV 76_ FNQWK 81_ SKECV 86_ CPNCS 91_ RSIAA 96_ SRFAP 101_ HLEKC 106_ LGMGR 111_ NSSRI 116_ ANRRI 121_ ANSNN 126_ MNKSE 131_ SDQED 136_ NDDIN 141_ DNDWS 146_ YGSEK 151_ KAKKR 156_ KSDKN 161_ PNSPR 166_ RSKSL 171_ KHKNG 176_ ELSNS 181_ DPFKY 186_ NNSTG 191_ ISYET 196_ LGPEE 201_ LRSLL 206_ TTQCG 211_ VISEH 216_ TKKMC 221_ TRSLR 226_ CPQHT 231_ DEQRR 236_ TVRIY 241_ FLGPS 246_ AVLPE 251_ VESSL 256_ DNDSF 261_ DMTDS 266_ QALIS 271_ RLQWD 276_ GSSDL 281_ SPSDS 286_ GSSKT 291_ SENQG 296_ WGLGT 301_ NSSES 306_ RKTKK 311_ KKSHL 316_ SLVGT 321_ ASGLG 326_ SNKKK 331_ KPKPP 336_ APPTP 341_SIYDD
1: Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B (PubMed:18206972, PubMed:21746879). The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex (PubMed:18206972). Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B (PubMed:27601583)