Telomere attrition and p53 response 1 protein
1_MEERK 6_ EEGEA 11_ EIQEH 16_ GPEHW 21_ FSKWE 26_ RQCLA 31_ EAEQD 36_ EQLPP 41_ ELQEE 46_ AAAAA 51_ QPEHK 56_ QQKLW 61_ HLFQN 66_ SATAV 71_ AQLYK 76_ DRVCQ 81_ QPGLS 86_ LWVPF 91_ QNAAT 96_ AVTNL 101_ YKESV 106_ DTHQR 111_ SFDIG 116_ IQIGY 121_ QRRNK 126_ DVLAW 131_ VKKRR 136_ RTIRR 141_ EDLIS 146_ FLCGK 151_ VPPPR 156_ NSRAP 161_ PRLTV 166_ VSPNR 171_ ATSTE 176_ TSSSV 181_ ETDLQ 186_ PFREA 191_ IALHG 196_ LSGAM 201_ ASISV 206_ RSSTP 211_ GSPTH 216_ VSSGS 221_ NASRR 226_ RNGLH 231_ DVDLN 236_ TFISE 241_ EMALH 246_ LDNGG 251_ TRKRT 256_ SAQCG 261_ DVITD 266_SPTHK
1: Acts as a central player within a network of stress response pathways promoting cellular adaptability. The E3 ligase HUWE1 assists HAPSTR1 in controlling stress signaling and in turn, HUWE1 feeds back to promote the degradation of HAPSTR1. HAPSTR1 represents a central coordination mechanism for stress response programs (PubMed:35776542). Functions as a negative regulator of TP53/P53 in the cellular response to telomere erosion and probably also DNA damage (PubMed:33660365). May attenuate p53/TP53 activation through the E3 ubiquitin ligase HUWE1 (PubMed:33660365)