Pre-mRNA-splicing regulator WTAP (Female-lethal(2)D homolog) (hFL(2)D) (WT1-associated protein) (Wilms tumor 1-associating protein)
1_MTNEE 6_ PLPKK 11_ VRLSE 16_ TDFKV 21_ MARDE 26_ LILRW 31_ KQYEA 36_ YVQAL 41_ EGKYT 46_ DLNSN 51_ DVTGL 56_ RESEE 61_ KLKQQ 66_ QQESA 71_ RRENI 76_ LVMRL 81_ ATKEQ 86_ EMQEC 91_ TTQIQ 96_ YLKQV 101_ QQPSV 106_ AQLRS 111_ TMVDP 116_ AINLF 121_ FLKMK 126_ GELEQ 131_ TKDKL 136_ EQAQN 141_ ELSAW 146_ KFTPD 151_ SQTGK 156_ KLMAK 161_ CRMLI 166_ QENQE 171_ LGRQL 176_ SQGRI 181_ AQLEA 186_ ELALQ 191_ KKYSE 196_ ELKSS 201_ QDELN 206_ DFIIQ 211_ LDEEV 216_ EGMQS 221_ TILVL 226_ QQQLK 231_ ETRQQ 236_ LAQYQ 241_ QQQSQ 246_ ASAPS 251_ TSRTT 256_ ASEPV 261_ EQSEA 266_ TSKDC 271_ SRLTN 276_ GPSNG 281_ SSSRQ 286_ RTSGS 291_ GFHRE 296_ GNTTE 301_ DDFPS 306_ SPGNG 311_ NKSSN 316_ SSEER 321_ TGRGG 326_ SGYVN 331_ QLSAG 336_ YESVD 341_ SPTGS 346_ ENSLT 351_ HQSND 356_ TDSSH 361_ DPQEE 366_ KAVSG 371_ KGNRT 376_ VGSRH 381_ VQNGL 386_ DSSVN 391_VQGSV
1: Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724)