Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (Methyl methanesulfonate (MMF)-inducible fragment protein 1)
1_MESET 6_ EPEPV 11_ TLLVK 16_ SPNQR 21_ HRDLE 26_ LSGDR 31_ GWSVG 36_ HLKAH 41_ LSRVY 46_ PERPR 51_ PEDQR 56_ LIYSG 61_ KLLLD 66_ HQCLR 71_ DLLPK 76_ QEKRH 81_ VLHLV 86_ CNVKS 91_ PSKMP 96_ EINAK 101_ VAEST 106_ EEPAG 111_ SNRGQ 116_ YPEDS 121_ SSDGL 126_ RQREV 131_ LRNLS 136_ SPGWE 141_ NISRP 146_ EAAQQ 151_ AFQGL 156_ GPGFS 161_ GYTPY 166_ GWLQL 171_ SWFQQ 176_ IYARQ 181_ YYMQY 186_ LAATA 191_ ASGAF 196_ VPPPS 201_ AQEIP 206_ VVSAP 211_ APAPI 216_ HNQFP 221_ AENQP 226_ ANQNA 231_ APQVV 236_ VNPGA 241_ NQNLR 246_ MNAQG 251_ GPIVE 256_ EDDEI 261_ NRDWL 266_ DWTYS 271_ AATFS 276_ VFLSI 281_ LYFYS 286_ SLSRF 291_ LMVMG 296_ ATVVM 301_ YLHHV 306_ GWFPF 311_ RPRPV 316_ QNFPN 321_ DGPPP 326_ DVVNQ 331_ DPNNN 336_ LQEGT 341_ DPETE 346_ DPNHL 351_ PPDRD 356_ VLDGE 361_ QTSPS 366_ FMSTA 371_ WLVFK 376_ TFFAS 381_ LLPEG 386_PPAIA
1: Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16289116, PubMed:28827405). Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway (PubMed:18307982)