Mortality factor 4-like protein 2 (MORF-related gene X protein) (Protein MSL3-2) (Transcription factor-like protein MRGX)
1_MSSRK 6_ QGSQP 11_ RGQQS 16_ AEEEN 21_ FKKPT 26_ RSNMQ 31_ RSKMR 36_ GASSG 41_ KKTAG 46_ PQQKN 51_ LEPAL 56_ PGRWG 61_ GRSAE 66_ NPPSG 71_ SVRKT 76_ RKNKQ 81_ KTPGN 86_ GDGGS 91_ TSEAP 96_ QPPRK 101_ KRARA 106_ DPTVE 111_ SEEAF 116_ KNRME 121_ VKVKI 126_ PEELK 131_ PWLVE 136_ DWDLV 141_ TRQKQ 146_ LFQLP 151_ AKKNV 156_ DAILE 161_ EYANC 166_ KKSQG 171_ NVDNK 176_ EYAVN 181_ EVVAG 186_ IKEYF 191_ NVMLG 196_ TQLLY 201_ KFERP 206_ QYAEI 211_ LLAHP 216_ DAPMS 221_ QVYGA 226_ PHLLR 231_ LFVRI 236_ GAMLA 241_ YTPLD 246_ EKSLA 251_ LLLGY 256_ LHDFL 261_ KYLAK 266_ NSASL 271_ FTASD 276_ YKVAS 281_AEYHR
1: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones