BRISC complex subunit Abraxas 2 (Abraxas brother protein 1) (Protein FAM175B)
1_MAASI 6_ SGYTF 11_ SAVCF 16_ HSANS 21_ NADHE 26_ GFLLG 31_ EVRQE 36_ ETFSI 41_ SDSQI 46_ SNTEF 51_ LQVIE 56_ IHNHQ 61_ PCSKL 66_ FSFYD 71_ YASKV 76_ NEESL 81_ DRILK 86_ DRRKK 91_ VIGWY 96_ RFRRN 101_ TQQQM 106_ SYREQ 111_ VLHKQ 116_ LTRIL 121_ GVPDL 126_ VFLLF 131_ SFIST 136_ ANNST 141_ HALEY 146_ VLFRP 151_ NRRYN 156_ QRISL 161_ AIPNL 166_ GNTSQ 171_ QEYKV 176_ SSVPN 181_ TSQSY 186_ AKVIK 191_ EHGTD 196_ FFDKD 201_ GVMKD 206_ IRAIY 211_ QVYNA 216_ LQEKV 221_ QAVCA 226_ DVEKS 231_ ERVVE 236_ SCQAE 241_ VNKLR 246_ RQITQ 251_ RKNEK 256_ EQERR 261_ LQQAV 266_ LSRQM 271_ PSESL 276_ DPAFS 281_ PRMPS 286_ SGFAA 291_ EGRST 296_ LGDAE 301_ ASDPP 306_ PPYSD 311_ FHPNN 316_ QESTL 321_ SHSRM 326_ ERSVF 331_ MPRPQ 336_ AVGSS 341_ NYAST 346_ SAGLK 351_ YPGSG 356_ ADLPP 361_ PQRAA 366_ GDSGE 371_ DSDDS 376_ DYENL 381_ IDPTE 386_ PSNSE 391_ YSHSK 396_ DSRPM 401_ AHPDE 406_DPRNT
1: Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148)